Molecular mechanisms of pupal metamorphosis
Project/Area Number |
22380032
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Applied entomology
|
Research Institution | Hirosaki University |
Principal Investigator |
HIRUMA Kiyoshi 弘前大学, 農学生命科学部, 教授 (70374816)
|
Co-Investigator(Kenkyū-buntansha) |
TOMITA Shuichiro 農業生物資源研究所, 主任研究員 (30360457)
|
Co-Investigator(Renkei-kenkyūsha) |
SHINODA Tetsuro 農業生物資源研究所, ユニット長 (10355620)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2012: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2010: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
|
Keywords | 昆虫生理学 / 昆虫ホルモン / エクダイソン / 幼若ホルモン / 変態 / コミットメント / カイコ / Verson's gland / アラタ体 / 前胸腺 / 転写因子 |
Research Abstract |
We have studied molecular mechanisms of pupal metamorphosis in Bombyx mori, specifically; (1) We determined using a singles celled Verson’s gland that the pupal commitment of one cell occurs gradually with various intermediate phases, which is different from the well known hypothesis. (2) Our preliminary studies showed that the decline in the competent of larval specific crochet forming cells, is due to nutrients by inactivating the insulin signaling pathway. (3) The cessation of JH biosynthesis in the last instar larvae is caused by several factors to work together to guarantee its cessation; such as the decline in ecdysone titer and the release of dopamine and sNPF. (4) The ecdysone inducible transcription factor BHR4 acts back to the prothoracic glands to suppress the ecdysone biosynthesis, so that this factor regulates the timing of pupal ecdysis.
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Report
(4 results)
Research Products
(46 results)