Functional analysis of baculoviral long non-coding RNAs
| Project/Area Number |
22380033
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied entomology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KATSUMA Susumu 東京大学, 大学院・農学生命科学研究科, 准教授 (20378863)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Keywords | バキュロウイルス / 非コード RNA / カイコ / 昆虫ウイルス / 病原性 / 非コードRNA / 昆虫 / 発現制御 / 遺伝子 / 転写 / ウイルス |
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| Research Abstract |
The baculoviruses possess a large circular, dsDNA genome encapsidated within a rodshaped virion. During the transcriptome analysis of baculovirus-infected cells, we identified more than one hundred of putative long non-coding RNAs (ncRNAs), most of which are expressed from recognized baculovirus early or late promoter motifs. To understand better the roles of these putative ncRNAs, we have generated 13 mutant NPVs whose ncRNA promoters are inactivated. We found that most of the mutants showed defects in virus growth, indicating that baculovirus longncRNAs play important roles in virus propagation.
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Report
(4 results)
Research Products
(53 results)
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[Journal Article] BmDJ-1 is a key regulator for the developmental oxidative modification of the silkworm, Bombyx mori2011
Author(s)
Tabunoki H, Ode H, Banno Y, Katsuma S, Shimada T, Mita K, Yamamoto K, Sato R, Ishii-Nozawa R, and Satoh J-I
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Peer Reviewed
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