Molecular mechanism of inflammatory cytokine signaling and its regulation by bioprobes
| Project/Area Number |
22380060
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied biochemistry
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| Research Institution | Kyoto Institute of Technology |
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Principal Investigator |
KATAOKA Takao 京都工芸繊維大学, 工芸科学研究科, 准教授 (20242307)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
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| Keywords | シグナル伝達 / 生理活性 / 炎症性サイトカイン / NF-κB / トリエン-アンサマイシン / トリコテセン / オイデスマン / TNF-α / デオキシニバレノール / SRC2 / ERK / p38 MAPキナーゼ / 免疫学 / 薬理学 |
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| Research Abstract |
Inflammatory cytokines, such as tumor necrosis factor-α and interleukin-1, induce the activation of the transcription factor nuclear factor κB (NF-κB) signaling pathway, and regulate diverse cellular functions through its gene expression. Inflammatory cytokines are shown to be involved in autoimmune diseases, cancer, and diabetes. In this study, mechanisms of actions of bioactive small compounds (bioprobes) on the NF-κB signaling pathway and gene expression induced by inflammatory cytokines were elucidated.
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Report
(4 results)
Research Products
(61 results)
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[Journal Article] Eudesmane-type sesquiterpene lactones inhibit multiple steps in the NF-κB signaling pathway induced by inflammatory cytokines.2012
Author(s)
Tamura R, Chen Y, Shinozaki M, Arao K, Wang L, Tang W, Hirano S, Ogura H, Mitsui T, Taketani S, Ando M, Kataoka T.
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Journal Title
Bioorg. Med. Chem. Lett.
Volume: 201222(1)
Issue: 1
Pages: 207-211
DOI
Related Report
Peer Reviewed
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