| Project/Area Number |
22380067
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Gifu University |
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Principal Investigator |
KISO MAKOTO 岐阜大学, 応用生物科学部, 特任教授 (90092931)
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| Co-Investigator(Kenkyū-buntansha) |
HIDEHARU Ishida 岐阜大学, 応用生物科学部, 教授 (20203002)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKESHI Tsubata 東京医科歯科大学, 疾患生命科学研究部, 教授 (80197756)
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| Project Period (FY) |
2010-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2010: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | シアル酸 / 糖鎖 / ガングリオシド / DDS / ウィルス感染 / マイコプラズマ / CD22 / 創薬 / シアロ糖鎖 / PECAM / レクチン / ガレクチン９ / セレノラクトース / セレノグリコシド / X線結晶構造解析 / 神経疾患 / グルコシルセラミド / 1分子イメージング / ラフトマーカー / GBS / ポリオーマウィルス / インフルエンザウィルス / Siglec-2 / 自己免疫性神経疾患 / インフルエンザ / シアリダーゼ阻害剤 |
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| Outline of Final Research Achievements |
Sialic acid-linked glycan chains (sialoglycans) are located on cell surface as the components of glycolipid gangliosides and glycoproteins, serving the receptor functions for microbial toxins and viral infections. They are also related to cell adhesion, cell-cell communication, immune response, cell growth and differentiation, oncogenesis, inflammation, and neural disorders, etc. In this research project, based on the development of practical chemical synthesis and construction of the library of sialoglycan complexes, as well as on the structure-activity relationship study, development of the glycan-driven drug delivery system (glycan DDS) and the single-molecule imaging of membrane functions by the newly synthesized fluorescent gangliosides were achieved. The glycan roles on the stem cell surface were studied by novel technology.
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