Enhancement of dietary peptide-induced GLP-1 secretion by indigestible saccharides
| Project/Area Number |
22380070
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Hokkaido University |
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Principal Investigator |
HARA Hiroshi 北海道大学, (連合)農学研究科(研究院), 教授 (70198894)
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| Co-Investigator(Kenkyū-buntansha) |
HIRA Tohru 北海道大学, 大学院農学研究院, 講師 (10396301)
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| Project Period (FY) |
2010-04-01 – 2013-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2010: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
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| Keywords | GLP-1 / 消化抵抗性糖質 / 食品ペプチド / 消化管ホルモン / 難消化性糖質 / 難消化性ペプチド / インクレチン / 低消化性糖質 |
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| Research Abstract |
GLP-1 is one of gastrointestinal hormones, and it has potent anti-obese and anti-diabetic effects. In the present project, we investigated whether indigestible peptides or indigestible saccharides are effective to increase GLP-1 secretion in a cell culture model and animal models. We also examined combined effects of indigestible saccharides and a dietary peptide.
We demonstrated that oral administration of a dietary peptide (corn peptide) potently stimulated GLP-1 secretion and it resulted in reduced glycemic response in normal and diabetic rats.
Luminal and oral administration of an indigestible saccharide (resistant maltodextrin, RMD) stimulated GLP-1 secretion in rats, and continuous ingestion of RMD also enhanced basal GLP-1 secretion. Furthermore, rats continuously having RMD showed increased GLP-1 secretory response to oral administration the corn peptide. These results revealed potential and combined effects of indigestible saccharides and dietary peptides in vivo.
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Report
(4 results)
Research Products
(51 results)
