Analysis of the stimulating effect of tryptophan on hepatic protein synthesis and evaluation of the effectiveness and safety of tryptophan intake
| Project/Area Number |
22380071
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Utsunomiya University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KABUYAMA Yukihito 宇都宮大学, 農学部, 教授 (20285042)
TACHIBANA Tetsuya 愛媛大学, 農学部, 准教授 (80346832)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Keywords | アミノ酸 / トリプトファン / 肝タンパク質合成 / 脳・神経 / シグナル伝達 |
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| Research Abstract |
The stimulating effect of tryptophan on hepatic protein synthesis and the effectiveness and safety of tryptophan intake were investigated in rat. Tryptophan administration seems to lead to the increase in the level of spermine, which is involved in cell growth, in the liver and thereby to stimulate hepatic protein synthesis. Furthermore, oral administration of large dose of tryptophan induces an increase in serotonergic neuronal activity in the amygdala, a brain region involved in occurrence of the mood via serotonergic system, and thus may induce unpleasant emotions.
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Report
(4 results)
Research Products
(11 results)
