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Analysis of the stimulating effect of tryptophan on hepatic protein synthesis and evaluation of the effectiveness and safety of tryptophan intake

Research Project

Project/Area Number 22380071
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Food science
Research InstitutionUtsunomiya University

Principal Investigator

YOSHIZAWA Fumiaki  宇都宮大学, 農学部, 教授 (10269243)

Co-Investigator(Kenkyū-buntansha) KABUYAMA Yukihito  宇都宮大学, 農学部, 教授 (20285042)
TACHIBANA Tetsuya  愛媛大学, 農学部, 准教授 (80346832)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Keywordsアミノ酸 / トリプトファン / 肝タンパク質合成 / 脳・神経 / シグナル伝達
Research Abstract

The stimulating effect of tryptophan on hepatic protein synthesis and the effectiveness and safety of tryptophan intake were investigated in rat. Tryptophan administration seems to lead to the increase in the level of spermine, which is involved in cell growth, in the liver and thereby to stimulate hepatic protein synthesis. Furthermore, oral administration of large dose of tryptophan induces an increase in serotonergic neuronal activity in the amygdala, a brain region involved in occurrence of the mood via serotonergic system, and thus may induce unpleasant emotions.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (11 results)

All 2012 2011 2010 Other

All Presentation (11 results)

  • [Presentation] トリプトファン経口投与にともなう肝臓タンパク質発現変化の網羅的解析2012

    • Author(s)
      小池慎一郎
    • Organizer
      日本アミノ酸学会第6回学術大会
    • Place of Presentation
      千葉大学園芸学部(千葉県)
    • Year and Date
      2012-09-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Analysis of extracellular levels of serotonin in rat amygdala after oral administration of large amounts of tryptophan2012

    • Author(s)
      Fumiaki Yoshizawa
    • Organizer
      Experimental Biology 2012
    • Place of Presentation
      San Diego Convention Center (USA)
    • Year and Date
      2012-04-24
    • Related Report
      2012 Final Research Report
  • [Presentation] トリプトファン経口投与後のラット扁桃体細胞間隙セロトニン動態の解析2011

    • Author(s)
      吉澤史昭
    • Organizer
      日本トリプトファン研究会第33回学術集会
    • Place of Presentation
      東邦大学薬学部(千葉県)
    • Year and Date
      2011-12-03
    • Related Report
      2012 Final Research Report
  • [Presentation] トリプトファン経口投与後のラット扁桃体細胞間隙セロトニン動態の解析2011

    • Author(s)
      吉潭史昭
    • Organizer
      日本トリプトファン研究会 第33回学術集会
    • Place of Presentation
      東邦大学薬学部(千葉県)
    • Year and Date
      2011-12-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Analysis of extracellular levels of serotonin in rat amygdala after oral administration of large amounts of tryptophan2011

    • Author(s)
      Fumiaki Yoshizawa
    • Organizer
      XI Asian Congress of Nutrition 2011
    • Place of Presentation
      Suntec Singapore International Convention & Exhibition Centre (Singapore)
    • Year and Date
      2011-07-14
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] トリプトファン経口投与後のラット扁桃体細胞間隙セロトニン動態の解析2010

    • Author(s)
      本田愛美
    • Organizer
      日本アミノ酸学会第4回学術大会
    • Place of Presentation
      ホテルサンシャイン鬼怒川(栃木県)
    • Year and Date
      2010-09-16
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] Effects of Orally Administered Tryptophan on the Extracellular Levels of Serotonin and Its Metabolite in Rat Amygdala2010

    • Author(s)
      Manami Honda
    • Organizer
      The 14th AAAP Animal Science Congress
    • Place of Presentation
      屏東科学技術大学(台湾)
    • Year and Date
      2010-08-26
    • Related Report
      2012 Final Research Report
  • [Presentation] Effects of Orally Administered Tryptophan on the Extracellular Levels of Serotonin and Its Metabolite in Rat Amygdala2010

    • Author(s)
      Manami Honda
    • Organizer
      The 14^<th> AAAP Animal Science Congress
    • Place of Presentation
      屏東科学技術大学(台湾)
    • Year and Date
      2010-08-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラット扁桃体細胞間隙セロトニン代謝産物に対するトリプトファン経口投与の影響2010

    • Author(s)
      本田愛美
    • Organizer
      第64回日本栄養・食糧学会大会
    • Place of Presentation
      アスティとくしま(徳島県)
    • Year and Date
      2010-05-22
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] Analysis of extracellular levels of serotonin in rat amygdala after oral administration of large amounts of tryptophan.

    • Author(s)
      Fumiaki Yoshizawa
    • Organizer
      Experimental Biology 2012
    • Place of Presentation
      San Diego Convention Center (USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] トリプトファン経口投与にともなう肝臓タンパク質発現変化の網羅的解析

    • Author(s)
      小池慎一郎
    • Organizer
      日本アミノ酸学会 第6回学術大会
    • Place of Presentation
      千葉大学園芸学部(千葉県)
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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