Evaluatuion ofstress-inducedactivation of quercetinand its multifunctional dynamics
| Project/Area Number |
22380077
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | The University of Tokushima |
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Principal Investigator |
TERAO Junji 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (60093275)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAI Yoshichika 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (50380027)
MUKAI Rie 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (90547978)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2010: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Keywords | 食品 / ストレス / 発現制御 / 分析化学 / シグナル伝達、筋萎縮 / β-βグルクロニダーゼ / 炎症 / シグナル伝達 / 筋萎縮 / 筋委縮 / β-グルクロニダーゼ / 分析科学 / 潰瘍性大腸炎 / フラボノイド |
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| Research Abstract |
This study was aimed to evaluate the multifunctional mechanism of quercetin as a antioxidative ingredient derived from plant foods. Rodent experiments demonstrated that dietary quercetin protects the intestinal mucosa of digestive tract, blood vessel, central nervous system and muscle tissue from oxidative stress by promoting the antioxidant enzyme expression as well asdirect ROS-scavenging and suppression of oxidant enzymes. It is implied that de-conjugation reaction by macrophage participates in these multifunction of dietary quercetin.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Plasma HDL reduces nonesterified fatty acid hydroperoxides originating from oxidized LDL: a mechanism for its antioxidant ability2013
Author(s)
Kotosai M., Shimada S., Kanda M., Matsuda N., Sekido K., Shimizu Y., Tokumura A.,Nakamura T., Murota K., Kawai Y., TeraoJ.
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Journal Title
Lipids
Volume: 48
Issue: 6
Pages: 569-578
DOI
Related Report
Peer Reviewed
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