Grant-in-Aid for Scientific Research (B)
Epidemiological studies provide evidence showing that early malnutrition may increase the risk ofschizophrenia. The goal of the present study is to clarify effects of early amino acid/protein malnutrition on sensorimotor gating deficits, which have relevance to schizophrenia. We examined prepulse inhibition (PPI) of two different mouse models of early nutritional deficiencies, which recapture genetic serine deficiency and prenatal protein malnutrition. PPI is an operational measure of sensorimotor gating that is impaired in both human patients and rodent models of schizophrenia. We observed that in adulthood the serene deficiency model and the protein malnutrition model exhibited reduced levels of PPI in a gender specific manner. These results suggest that both serine deficiency and protein malnutrition during early developmental stages increase the risk of sex-dependent sensorimotor gating deficits
Biosci. Biotechnol. Biochem.
別冊 日本臨牀 新領域別症候群シリーズ「先天代謝異常症候群（第2版）病因･病態研究，診断･治療の進歩」
J. Nutr. Food Sci
Medicine and Biology
J. Biol. Chem.
Journal of Biological Chemistry
Attribution of KAKENHI