| Project/Area Number |
22380097
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Wood science
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| Research Institution | Kyushu University |
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Principal Investigator |
KONDO Tetsuo 九州大学, 大学院・農学研究院, 教授 (30202071)
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| Co-Investigator(Renkei-kenkyūsha) |
TATSUMI Daisuke 九州大学, 大学院・農学研究院, 准教授 (60293908)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2010: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
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| Keywords | セルロース / テンプレート / バイオファブリケーション / ホスト-ゲスト バイオミネラリゼーション / ヒドロキシアパタイト / ホスト-ゲスト バイオミネラリゼーション |
|---|
| Research Abstract |
This study attempts to propose a sortof biomimic mineralization using the template. It combines morphologically controlling process with synthesis of the calcium phosphate as a major component of bones. This process was successfully mediated by the modified NOC template having a pair of roles of the ion supply sources and scaffolds for 3D-ordering architecture of the calcium phosphate as a biomineral in the key functions for biomineralization. Secondly, the ordered cellulosefilm scaffold, NOC, also induced establishment of a three-dimensional, hierarchical structure of epidermal cells by cell attachment and subsequent culture. Furthermore, the NOC film, as a semipermeable template, was also employed to allow three-dimensional proliferation of epidermal cell layers in the perpendicular direction. The template provedto be a suitable as a three-dimensional cell culture device, resulting in the proposal that the construction processes of these three-dimensional cell layers followed the basic concept of skin formation
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