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Mechanisms to detoxify hydrogen sulfide using special amino acids in deep-sea organisms

Research Project

Project/Area Number 22380107
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General fisheries
Research InstitutionThe University of Tokyo

Principal Investigator

INOUE Koji  東京大学, 大気海洋研究所, 准教授 (60323630)

Co-Investigator(Renkei-kenkyūsha) TOYOHARA Haruhiko  京都大学, 農学研究科, 准教授 (90183079)
MARUYAMA Tadashi  独立行政法人海洋研究開発機構, 海洋・極限環境生物圏領域, プログラムディレクター (90373464)
Project Period (FY) 2010-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2010: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywords適応 / 特殊環境 / 深海 / 熱水噴出域 / 硫化水素 / 生理学 / 共生 / 無脊椎動物
Research Abstract

We studied the adaptation mechanisms to toxic hydrogen sulfide in deep-sea hydrothermal vent-specific animals through the analysis of the synthetic pathway of hypotaurine, which is a precursor of taurine and can bind to hydrogen sulfide and generate non-toxic thiotaurine. We identified the hypotaurine synthesis pathway, which has not been reported in any marine invertebrates, in the deep-sea mussel Bathymodiolus septemdierum. We also revealed that the genes of the enzymes involved in the hypotaurine synthesis actively expressed in the gill regardless of the sulfide concentration in the rearing water. We also analyzed the free amino acids including hypotaurine and its precursors to confirm the activity of the pathway. Bivalves may have acquired the habitat of hydrothermal vent area by utilizing a part of the taurine synthesis pathway.

Report

(5 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (50 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (13 results) (of which Peer Reviewed: 11 results) Presentation (35 results) Remarks (2 results)

  • [Journal Article] Nematode community composition in hydrothermal vent and adjacent non-vent fields around Myojin Knoll, a seamount on the Izu-Ogasawara Arc in the western North Pacific Ocean2014

    • Author(s)
      Setoguchi, Y., Nomaki, H., Kitahashi, T., Watanabe, H., Inoue, K., Ogawa, NO, Shimanaga, M.
    • Journal Title

      Mar. Biol

      Volume: (in press) Issue: 8 Pages: 1775-1785

    • DOI

      10.1007/s00227-014-2460-4

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evolutionary history of the GABA transporter (GAT) group revealed by marine invertebrate GAT-12013

    • Author(s)
      Kinjo, A., Koito, T., Kawaguchi, S., Inoue, K.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 12 Pages: e82410-e82410

    • DOI

      10.1371/journal.pone.0082410

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 魚介類の生態を支える生理機能に関する分子生物学的研究2013

    • Author(s)
      井上広滋
    • Journal Title

      日本水産学会誌

      Volume: 79 Pages: 315-318

    • NAID

      10031158637

    • URL

      https://www.jstage.jst.go.jp/article/suisan/79/3/79_WA1905/_pdf

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influence of water temperature on the larval development of Neoverruca sp. and Ashinkailepas seepiophila. Implications for larval dispersal and settlement in the vent and seep environments2013

    • Author(s)
      Yorisue, T. R. Kado, H. Watanabe, J. T. Hoeg, K. Inoue, S. Kojima, B. K. K. Chan
    • Journal Title

      Deep-Sea Research I

      Volume: 71 Pages: 33-37

    • DOI

      10.1016/j.dsr.2012.10.007

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of the amount of thiotrophic symbionts in the deep-sea mussel Bathymodiolus septemdierum under different sulfide levels by using fluorescent in situ hybridization2012

    • Author(s)
      Fujinoki, M.
    • Journal Title

      Fisheries Science

      Volume: 78 Issue: 1 Pages: 139-146

    • DOI

      10.1007/s12562-011-0419-7

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Whole-mount fluorescence in situ hybridization to visualize symbiotic bacteria in the gills of deep-sea mussels2012

    • Author(s)
      Fujinoki, M., Koito, T., Fujiwara, Y., Kawato M., Tada, Y., Hamasaki, K., Jimbo, M., and Inoue, K.
    • Journal Title

      Aquatic Biol

      Volume: 14 Issue: 2 Pages: 134-140

    • DOI

      10.3354/ab00385

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Trophic structure of hydrothermal vent communities at the Myojin Knoll and the Nikko Seamount in the northwestern Pacific : Implications for photosynthesis-derived food supply2012

    • Author(s)
      Yorisue, T., Inoue, K., Miyake, H., and Kojima, S.
    • Journal Title

      Plankton Benthos Res

      Volume: 7 Pages: 35-40

    • URL

      https://www.jstage.jst.go.jp/article/pbr/7/2/7_35/_pdf

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] New distribution record of deep-sea mussel, Bathymodiolus aduloides Hashimoto & Okutani 1994 [Mollusca : Bivalvia: Mytilidae] from a hydrothermal vent, Myojinsho2012

    • Author(s)
      Koito, T., Hashimoto, J., Nemoto, S., Kitajima, M., Kitada, M., Inoue, K.
    • Journal Title

      Marine Biodiversity Records

      Volume: 5

    • DOI

      10.1017/s1755267212000267

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 猛毒の硫化水素をエネルギー源とする深海生物の生存戦略2012

    • Author(s)
      井上広滋
    • Journal Title

      バイオサイエンスとインダストリー

      Volume: 70 Pages: 251-254

    • NAID

      10030768850

    • URL

      http://www.jba.or.jp/pc/archive/2012/vol70_no4.html

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Journal Article] Trophic structure of hydrothermal vent communities at the Myojin Knoll and the Nikko Seamount in the northwestern Pacific: Implications for photosynthesis-derived food supply.2012

    • Author(s)
      Yorisue T
    • Journal Title

      Plankton and Benthos Research

      Volume: 7 Pages: 35-40

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decline in taurine transporter mRNA and thioautotrophic bacterial 16SrDNA levels after transplantation of the hydrothermal-vent mussel Bathymodiolus septemdierum to a non-vent position2010

    • Author(s)
      Tomoko Koito
    • Journal Title

      Cahiers de Biologie Marine

      Volume: 51 Pages: 429-433

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Larvae of deep-sea chemosynthetic ecosystem animals in captivity2010

    • Author(s)
      Hiroshi Miyake
    • Journal Title

      Cahiers de Biologie Marine

      Volume: 51 Pages: 441-450

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 熱水噴出域への適応機構をアミノ酸輸送体から探る2010

    • Author(s)
      井上広滋
    • Journal Title

      海洋と生物

      Volume: 32 Pages: 123-128

    • Related Report
      2010 Annual Research Report
  • [Presentation] シチヨウシンカイヒバリガイの共生菌獲得機構の解明2014

    • Author(s)
      津澤一輝
    • Organizer
      平成26年度日本水産学会春季大会
    • Place of Presentation
      北海道大学
    • Related Report
      2013 Final Research Report
  • [Presentation] 明神海丘の熱水域・被熱水域における線虫類群集の空間変異2014

    • Author(s)
      瀬戸口友佳
    • Organizer
      日本生態学会大会
    • Place of Presentation
      広島国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] シンカイヒバリガイ類のヒポタウリン蓄積機構 : NT11-09 とその後の展開2014

    • Author(s)
      井上広滋
    • Organizer
      ブルーアース2014
    • Place of Presentation
      東京海洋大学
    • Related Report
      2013 Final Research Report
  • [Presentation] 明神海丘の熱水域・非熱水域における線虫類群集の空間変異2014

    • Author(s)
      瀬戸口友佳,嶋永元裕,渡部裕美,野牧秀隆,北橋倫,井上広滋
    • Organizer
      第61回日本生態学会大会
    • Place of Presentation
      広島国際会議場,広島
    • Related Report
      2013 Annual Research Report
  • [Presentation] 海産無脊椎動物のGAT-1から解き明かすGABA輸送体グループの分子進化と機能進化2014

    • Author(s)
      金城梓,小糸智子,井上広滋
    • Organizer
      日本動物学会関東支部第66回大会
    • Place of Presentation
      東京大学大気海洋研究所,千葉
    • Related Report
      2013 Annual Research Report
  • [Presentation] シチヨウシンカイヒバリガイの共生菌獲得機構の解明2014

    • Author(s)
      津澤一輝,小糸智子,長崎稔拓,井上広滋,土田真二,廣海十朗
    • Organizer
      平成26年度公益社団法人日本水産学会春季大会
    • Place of Presentation
      北海道大学,北海道
    • Related Report
      2013 Annual Research Report
  • [Presentation] シンカイヒバリガイ類のヒポタウリン蓄積機構:NT11-09とその後の展開2014

    • Author(s)
      井上広滋,森司,中村欽光,小糸智子,大石和恵,長崎稔拓,日下部郁美,本郷悠貴,吉田尊雄,丸山正
    • Organizer
      ブルーアース2014
    • Place of Presentation
      東京海洋大学,東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 海産無脊椎動物のGAT-1 が解き明かすGABA 輸送体グループの分子進化と機能進化2013

    • Author(s)
      金城梓
    • Organizer
      日本動物学会関東支部第66回大会
    • Place of Presentation
      東京大学大気海洋研究所
    • Year and Date
      2013-03-15
    • Related Report
      2013 Final Research Report
  • [Presentation] 深海性二枚貝のセロトニン受容体遺伝子の発現動態2013

    • Author(s)
      小糸智子
    • Organizer
      平成25年度日本水産学会秋季大会
    • Place of Presentation
      三重大学
    • Related Report
      2013 Final Research Report
  • [Presentation] 魚介類の生態を支える生理機能に関する分子生物学的研究2013

    • Author(s)
      井上広滋
    • Place of Presentation
      東京海洋大学
    • Related Report
      2013 Final Research Report
  • [Presentation] シンカイヒバリガイ類とその共生菌の集団構造解析2013

    • Author(s)
      小糸智子
    • Organizer
      平成25年度日本水産学会春季大会
    • Place of Presentation
      東京海洋大学
    • Related Report
      2013 Final Research Report
  • [Presentation] 硫化物存在下でのシチヨウシンカイヒバリガイタウリントランスポーター遺伝子の発現誘導2013

    • Author(s)
      日下部郁美
    • Organizer
      平成25年度日本水産学会春季大会
    • Place of Presentation
      東京海洋大学
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Presentation] 深海性二枚貝におけるヒポタウリン生合成経路と硫化物に対する発現応答2013

    • Author(s)
      長崎稔拓
    • Place of Presentation
      東京海洋大学
    • Related Report
      2013 Final Research Report
  • [Presentation] 海産無脊椎動物のGAT-1 が解き明かすGABA 輸送体グループの進化の歴史2013

    • Author(s)
      金城梓
    • Organizer
      ブルーアース2013
    • Place of Presentation
      東京海洋大学
    • Related Report
      2013 Final Research Report
  • [Presentation] 硫化物存在下でのシチヨウシンカイヒバリガイタウリントランスポーター遺伝子の発現誘導2013

    • Author(s)
      日下部郁美
    • Organizer
      ブルーアース2013
    • Place of Presentation
      東京海洋大学
    • Related Report
      2013 Final Research Report
  • [Presentation] 深海性二枚貝のセロトニン受容体遺伝子の発現動態2013

    • Author(s)
      小糸智子,牧口祐也,井上広滋
    • Organizer
      平成25年度日本水産学会秋季大会
    • Place of Presentation
      三重大学,三重
    • Related Report
      2013 Annual Research Report
  • [Presentation] 明神海丘の熱水域・非熱水域における線虫類群集の空間変異2013

    • Author(s)
      瀬戸口友佳,嶋永元裕,渡部裕美,野牧秀隆,北橋倫,井上広滋
    • Organizer
      2013年日本ベントス学会・日本プランクトン学会合同大会
    • Place of Presentation
      東北大学,宮城
    • Related Report
      2013 Annual Research Report
  • [Presentation] 深海性二枚貝におけるヒポタウリン生合成経路と硫化物に対する発現応答2013

    • Author(s)
      長﨑稔拓
    • Organizer
      平成25年度日本水産学会春季大会
    • Place of Presentation
      東京海洋大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] シチヨウシンカイヒバリガイ類とその共生菌の集団構造解析2013

    • Author(s)
      小糸智子
    • Organizer
      平成25年度日本水産学会春季大会
    • Place of Presentation
      東京海洋大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] 硫化物存在下でのシチヨウシンカイヒバリガイタウリントランスポーター遺伝子の発現誘導2013

    • Author(s)
      日下部郁美
    • Organizer
      ブルーアースシンポジウム
    • Place of Presentation
      東京海洋大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] シンカイヒバリガイ類のGAT-1から解き明かすGABA輸送体グループの進化の歴史2013

    • Author(s)
      金城梓
    • Organizer
      ブルーアースシンポジウム
    • Place of Presentation
      東京海洋大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] Mechanisms of adaptation to hydrothermal vents using taurine-related amino acids2012

    • Author(s)
      Inoue K.
    • Organizer
      Malaysia International Biological Symposium
    • Place of Presentation
      Serdan, Malaysia
    • Year and Date
      2012-07-12
    • Related Report
      2013 Final Research Report
  • [Presentation] 海産無脊椎動物のGAT-1 が示すGABA 輸送体グループの進化の歴史2012

    • Author(s)
      金城梓
    • Organizer
      東京大学生命科学シンポジウム
    • Place of Presentation
      東京大学
    • Year and Date
      2012-06-30
    • Related Report
      2013 Final Research Report
  • [Presentation] Mechanisms of adaptation to hydrothermal vents using taurine-related amino acids2012

    • Author(s)
      Inoue K.
    • Organizer
      University of Hawaii and University of Tokyo Joint Symposium on Ocean, Coastal, and Atmospheric Sciences
    • Place of Presentation
      University of Hawaii
    • Related Report
      2013 Final Research Report
  • [Presentation] Evolutionary history of the GABA transporter group revealed by marine invertebrate GAT-1 genes2012

    • Author(s)
      Kinjo A.
    • Organizer
      University of Hawaii and University of Tokyo Joint Symposium on Ocean, Coastal, and Atmospheric Sciences
    • Place of Presentation
      University of Hawaii
    • Related Report
      2013 Final Research Report
  • [Presentation] Mechanisms of adaptation to hydrothermal vents using taurine-related amino acids2012

    • Author(s)
      Inoue K
    • Organizer
      University of Hawaii and University of Tokyo Joint Symposium on Ocean Coastal, and Atmospheric Sciences
    • Place of Presentation
      University of Hawaii
    • Related Report
      2012 Annual Research Report
  • [Presentation] Evolutionary history of the GABA transporter group revealed by marine invertebrate GAT-1 genes2012

    • Author(s)
      Kinjo A
    • Organizer
      University of Hawaii and University of Tokyo Joint Symposium on Ocean Coastal, and Atmospheric Sciences
    • Place of Presentation
      University of Hawaii
    • Related Report
      2012 Annual Research Report
  • [Presentation] 海産無脊椎動物のGAT-1が示すGABA輸送体グループの進化の歴史2012

    • Author(s)
      金城梓
    • Organizer
      東京大学生命科学シンポジウム
    • Place of Presentation
      東京大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] 明神礁におけるカヅキシンカイヒバリガイの発見2011

    • Author(s)
      小糸智子
    • Organizer
      ブルーアース'11
    • Place of Presentation
      東京海洋大学(東京都)
    • Year and Date
      2011-03-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] NT10-08初島沖・明神海丘航海概要:化学合成生態系構成生物の環境適応機構・共生機構・微細構造の解明をめざして2011

    • Author(s)
      井上広滋
    • Organizer
      ブルーアース'11
    • Place of Presentation
      東京海洋大学(東京都)
    • Year and Date
      2011-03-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] シロウリガイ類を常圧下で飼育するためには2011

    • Author(s)
      根本卓
    • Organizer
      ブルーアース'11
    • Place of Presentation
      東京海洋大学(東京都)
    • Year and Date
      2011-03-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] 貝類のGAT-1 から見たGABA 輸送体グループの分子進化2011

    • Author(s)
      金城梓
    • Organizer
      東京大学生命科学シンポジウム
    • Place of Presentation
      長崎大学
    • Related Report
      2013 Final Research Report
  • [Presentation] タウリン関連物質による熱水噴出域への適応機構2011

    • Author(s)
      井上広滋
    • Organizer
      第14回マリンバイオテクノロジー学会
    • Place of Presentation
      東海大学
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] 貝類のGAT-1から見たGABA輸送体グループの分子進化2011

    • Author(s)
      金城梓
    • Organizer
      平成23年度日本水産学会秋季大会
    • Place of Presentation
      長崎大学
    • Related Report
      2011 Annual Research Report
  • [Presentation] 明神海丘における蔓脚類2種、ネッスイハナカゴとハツシマレパスの棲み分け機構2010

    • Author(s)
      頼末武史
    • Organizer
      2010年度日本プランクトン学会・日本ベントス学会合同大会
    • Place of Presentation
      東京大学大気海洋研究所(千葉県)
    • Year and Date
      2010-10-11
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://darwin.aori.u-tokyo.ac.jp/inouelab/index.html

    • Related Report
      2013 Final Research Report
  • [Remarks] Inoue Laboratory

    • URL

      http://darwin.aori.u-tokyo.ac.jp/inouelab/

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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