Novel approach to the distribution and function of globin proteins in aquatic organisms
| Project/Area Number |
22380115
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Fisheries chemistry
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| Research Institution | Tokai University (2011-2012)
The University of Tokyo (2010) |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2010: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Keywords | グロビン類 / タンパク質 / 構造 / 機能 / 分布 / グロビン / 生理機能 / ミオグロビン / 一次構造 / 立体構造 / 分子進化 / 系統解析 / 組換え体 / 構造安定性 / 分子動力学 |
|---|
| Research Abstract |
Attempts were made to clone the genes coding globin proteins (especially myoglobin) from a variety of fish species, and based on the deduced amino acid sequences and bioinformatic analyses, the profiles of molecular evolution and environment adaptation were examined. Distribution of globins was investigated by measuring the transcription and expression levels of globin genes in various tissues of several fish species. The properties and tissue distribution of mammalian globins were also examined. On the other hand, the physiological roles of myoglobin other than oxygen molecule binding were also found.
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Report
(4 results)
Research Products
(37 results)
