| Project/Area Number |
22380143
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Zootechnical science/Grassland science
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| Research Institution | Tohoku University |
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Principal Investigator |
KATOH Kazuo 東北大学, 大学院・農学研究科, 教授 (60091831)
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| Co-Investigator(Kenkyū-buntansha) |
SANO Hiroaki 岩手大学, 農学部, 教授 (20196306)
ROH Sang-gun 東北大学, 大学院・農学研究科, 准教授 (90322130)
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| Co-Investigator(Renkei-kenkyūsha) |
HIRAYAMA Takuji 琉球大学, 農学部, 助教 (00274887)
HAGINO Akihiko 東北大学, 大学院・農学研究科, 助教 (80156249)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2010: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Keywords | 黒毛和種牛 / 遺伝子多型 / 成長ホルモン / 脂肪細胞 / インスリン / 不飽和脂肪酸 / GH分泌 / 脂肪酸合成 |
|---|
| Research Abstract |
1) We successfully established an applied method of Dot-plot-SNP for analyzing GH single nucleotide polymorphisms (SNPs), 2) In the studies on gene expression of fatty acid synthesis enzymes (FASN, SCD and SREBP-1), adipocytes isolated from the animal with type CC demonstrated greater sensitivity to GH stimulation than those with another type, 3) Glucose-clamp analysis demonstrated greater insulin sensitivity in the animals with the type AA than that with type BB.
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