| Budget Amount *help |
¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2011: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2010: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
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| Research Abstract |
This research project had been conducted to elucidate the interaction between Babesia parasites and host erythrocytes during their asexual growth. The findings are summarized below.
1) Na, K-ATPase, an erythrocytic enzyme, is found on the surface of Babesia parasite. 2) A spherical body protein (SBP) expressed by Babesia parasite is released into the cytoplasm of the infected erythrocytes at the late phase of infection. 3) Micronemal proteins of Babesia parasites act as adhesion molecules to the receptors of host erythrocytes. 4) A surface antigen of Babesia parasite can interact with the erythrocytic actin during the infection. 5) Babesia parasite shows a unique "Gliding motility" during erythrocyte invasion. 6) Babesia parasite can escape from host immunity by activating host Treg cells. 7) Erythrocyte invasion of Babesia parasites can be inhibited by disturbing the molecular interactions between the protozoan ligands and host receptors.
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