| Budget Amount *help |
¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2010: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Research Abstract |
To investigate the response mechanisms within the midgut environment, including those influenced by resident microbiota against malaria parasite, we focus on a midgut bacteria species intra-specific variation that confers diversity to the mosquito`s competency for malaria parasite transmission. Serratia marcescens isolated from laboratory-reared mosquitoes shows great phenotypic variation in its cellular and structural features. This variation is directly correlated with its ability to inhibit Plasmodium parasite development within the mosquito midgut. These findings indicated that strategies for controlling malaria through genetic manipulation of midgut bacteria within the mosquito.
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