Acquisition of the meiotic and mitotic competence during oocyte growth
| Project/Area Number |
22380156
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
AOKI Fugaku 東京大学, 大学院・新領域創成科学研究科, 教授 (20175160)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2012: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2010: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Keywords | 発生 / 成熟能 / 発生能 / 卵 / 初期胚 / 卵成熟 / 初期発生 / 母性因子 / 卵成長 |
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| Research Abstract |
Mammalian oocytes acquire the competence for meiotic maturation ad subsequent development during their growth in the ovaries. However, a part of fully grown oocytes do not have this competence. In the present study, to determine the factor(s) involved in this competence, I conducted the transcriptome analysis for the oocytes with and without the competence. Several candidates for the factor were obtained from this analysis. By inhibiting the expression of these candidates in the growing oocytes, I determined the target factors.
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Report
(4 results)
Research Products
(20 results)
