The spinal defecation center-mediated prokinetic effect of ghrelin and its involvement in dysmotility of the large intestine.
| Project/Area Number |
22380157
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Gifu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KURAMOTO Hiroshi 京都工芸繊維大学, 工芸科学研究科, 准教授 (30153373)
YAMAMOTO Yoshio 岩手大学, 農学部, 教授 (10252123)
HIRAYAMA Haruko 岡山大学, 自然生命科学研究支援センター, 助教 (40635257)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIINA Takahiko 岐阜大学, 応用生物科学部, 准教授 (90362178)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2011: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2010: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Keywords | グレリン / 大腸運動 / 排便 / 脊髄 / 消化管 / 下痢 / 便秘 / 骨盤神経 / ドーパミン / 術後障害 / デスアシルグレリン / グレリン受容体 |
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| Research Abstract |
The aim of this work was to clarify the regulatory mechanism of the central nervous system on gut motility. By using in vivo experimental system in which gut motility can be assessed in the presence of intact neural connection between the central nervous system and gut, it has been demonstrated that ghrelin and dopamine injected into the spinal defecation center elicit large propulsive colorectral motility. In addition, neurons sensitive to ghrelin and dopamine have been identified in the spinal cord. These findings would provide a novel therapeutic strategy for stress-induced diarrhea and constipation.
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Report
(4 results)
Research Products
(77 results)
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[Journal Article] Functional and in situ hybridisation evidence that preganglionic sympathetic vasocon- strictor neurons express ghrelin receptors.2010
Author(s)
Ferens D.M., Yin L., Bron R., Hunne B., Ohashi-Doi K., Kitchener P.D., Sanger G.J., Witherington J., Shimizu Y., Furness,J.B
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Journal Title
Neuroscience
Volume: Vol 166
Issue: 2
Pages: 671-679
DOI
Related Report
Peer Reviewed
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