Vertical transmission pattern of pathogens cause abortion of domestic animals

• Project/Area Number: 22380158
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Basic veterinary science/Basic zootechnical science
• Research Institution: Gifu University
• Principal Investigator: YASUHIRO TAKASHIMA 岐阜大学, 応用生物科学部, 准教授 (20333552)
• Co-Investigator(Kenkyū-buntansha): OHYA Kenji 岐阜大学, 応用生物科学部, 准教授 (50402219) ; 高須 正規 岐阜大学, 応用生物科学部, 准教授 (00503327)
• Co-Investigator(Renkei-kenkyūsha): TAKASU Masaki 岐阜大学, 応用生物科学部, 准教授 (00503327)
• Project Period (FY): 2010-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000); Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2011: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
• Keywords: 胎盤 / 家畜 / トキソプラズマ / 垂直感染 / 潜伏感染 / 白血球 / 体内伝播

Research Abstract

In this study, the dissemination of intracellular pathogen from maternal blood flow to the placenta was revealed. Even in the case of pathogens, which preferencially infect to the placenta, drastical accumulation of the infected maternal leukocytes was not observed in the placenta. It may be because the lack of expression of molecules related with cell adhesion on the most surface layer of the placenta. Physical disruption of the layer must be important for vertical transmission of intracellular pathogens.

Research Products

• [Journal Article] CD44 mediated Hyaluronan adhesion of Toxoplasma gondii-infected leukocytes (2014)
  • Author(s): Hayashi T., Unno A., Baba M., Ohno T., Kitoh K. Takashima Y
  • Journal Title: Parasitol. Int Volume: 63(2) Pages: 479-84
  • Peer Reviewed
• [Journal Article] CD44 mediated hyaluronan adhesion of Toxoplasma gondii-infected leukocytes. (2014)
  • Author(s): Hayashi T, Unno A, Baba M, Ohno T, Kitoh K, Takashima Y.
  • Journal Title: Parasitol Int. Volume: ６３ Issue: 2 Pages: 479-84
  • DOI: 10.1016/j.parint.2013.10.008
  • Peer Reviewed
• [Journal Article] Prevalence and dynamics of antibodies against NcSAG1 and NcGRA7 antigens of Neospora caninum in cattle during the gestation period (2013)
  • Author(s): Takashima Y., Takasu M., Yanagimoto I., Hattori N., Batanova T., Nishikawa Y., Kitoh K.
  • Journal Title: J. Vet. Med. Sci. Volume: 75(11) Pages: 1413-8
  • NAID: 120006342280
  • Peer Reviewed
• [Journal Article] Toxoplasma gondii tachyzoite-infected peripheral blood mononuclear cells are enriched in mouse lungs and liver (2013)
  • Author(s): Unno A., Kachi S., Batanova T., Ohno T, Elhawary N., Kitoh K., Takashima Y
  • Journal Title: Exp. Parasitol Volume: 134 Pages: 160-164
  • Peer Reviewed
• [Journal Article] Toxoplasma gondii tachyzoite-infected peripheral blood mononuclear cells are enriched in mouse lungs and liver. (2013)
  • Author(s): Unno A, Kachi S, Batanova TA, Ohno T, Elhawary N, Kitoh K, Takashima Y.
  • Journal Title: Exp Parasitol Volume: 134 Issue: 2 Pages: 160-164
  • DOI: 10.1016/j.exppara.2013.03.006
  • Peer Reviewed
• [Journal Article] Prevalence and dynamics of antibodies against NcSAG1 and NcGRA7 antigens of Neospora caninum in cattle during the gestation period. (2013)
  • Author(s): Takashima Y, Takasu M, Yanagimoto I, Hattori N, Batanova T, Nishikawa Y, Kitoh K.
  • Journal Title: J Vet Med Sci. Volume: 75 Pages: 1413-1418
  • NAID: 120006342280
  • Peer Reviewed
• [Presentation] マウス胎盤におけるトキソプラズマ感染白血球の挙動 (2013)
  • Author(s): 高島康弘
  • Organizer: 日本寄生虫学会
  • Place of Presentation: 東京医科歯科大学
• [Presentation] Toxoplasma gondii 感染THP-1 細胞におけるCD44 発現パターンの比較 (2012)
  • Author(s): 林武志, 鬼頭克也, 高島康弘
  • Organizer: 第154回日本獣医学会
  • Place of Presentation: 岩手大学
• [Presentation] Toxoplasma gondii感染THP-1細胞におけるCD44発現パターンの比較 (2012)
  • Author(s): 林武志
  • Organizer: 日本獣医学会
  • Place of Presentation: 岩手大学