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Elucidation of molecular mechanisms of pathophysiological pain via nociceptive channels and establishment of pain-evaluating system

Research Project

Project/Area Number 22380160
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Basic veterinary science/Basic zootechnical science
Research InstitutionTottori University

Principal Investigator

OHTA Toshio  鳥取大学, 農学部, 教授 (20176895)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Kenji  鳥取大学, 農学部, 准教授 (00400143)
Co-Investigator(Renkei-kenkyūsha) IMAGAWA Toshiaki  北海道大学, 理学研究科, 准教授 (20142177)
Project Period (FY) 2010-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Keywords薬理 / 痛み / Caイメージング / パッチクランプ / 侵害受容体 / 遺伝子発現 / Ca-imaging / TRPA1 / 熱感受性 / 遺伝子クローニング / TRPV1 / capsaicin / 変異チャネル / 細胞内Caイメージング / Xenopus Tropicalis / ポリモーダル受容体
Research Abstract

We cloned cDNA encoding nociceptive channels from amphibian and chicken and constructed expression vectors. We established nociception-evaluating system for elucidation of the pathophysiological significance of these receptors. Using this system, we found that the recognition sites for capsaicin, a pungent compound for TRPV1. Functional expression and characterizing of X. troplicalis TRPA1 revealed that amphibian TRPA1 showed heat sensitivity in contrast to homoeothermic homologues. By analyzing human and mouse TRPA1s, Cadmium, an environmental irritant and hydrogen sulfide, en endogenous inflammatory gasomessenger, could activate TRPA1 channel resulting in elicitation of acute pain. We identified amino acid residues regarding these chemical sensitivities by mutagenetic studies. These data suggest that nociceptive TRP channels are important molecule especially for inflammation-induced pathophysiological pain.

Report

(5 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (66 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (24 results) (of which Peer Reviewed: 19 results) Presentation (42 results)

  • [Journal Article] Molecular mechanism of 2-APB-induced Ca2+ influx in external acidification in PC122014

    • Author(s)
      Takahashi K, Yokota M, Ohta T.
    • Journal Title

      Exp Cell Res

      Volume: 323(2) Pages: 337-345

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Heat and noxious chemical sensor, chicken TRPA1, as a target of bird repellents and identification of its structural determinants by multispecies functional comparison2014

    • Author(s)
      Saito S, Banzawa N, Fukuta N, Takahashi K, Imagawa T, Ohta T, Tominaga M
    • Journal Title

      Mol Biol Evol

      Volume: 31(3) Pages: 708-722

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular mechanism of 2-APB-induced Ca2+ influx in external acidification in PC12.2014

    • Author(s)
      Takahashi K, Yokota M, Ohta T
    • Journal Title

      J Pharmacol Sci

      Volume: 124 Pages: 119-119

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Involvement of nociceptive TRPA1 channel in analgestic action of Limonene.2014

    • Author(s)
      Kaimoto T, Takahashi K, Saito S, Tominaga M, Ohta T
    • Journal Title

      J Pharmacol Sci

      Volume: 124 Pages: 155-155

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Identification of molecular determinants for a potent mammalian TRPA1 antagonist by utilizing species differences2013

    • Author(s)
      Nakatsuka K, Gupta R, Saito S, Banzawa N, Takahashi K, Tominaga M, Ohta T
    • Journal Title

      J Mol Neurosci

      Volume: 51(3) Pages: 754-762

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inflammatory acidic pH enhances hydrogen sulfide-induced TRPA1 activation in RIN-14B cells2013

    • Author(s)
      Takahashi K, Ohta T
    • Journal Title

      J Neurosci Res

      Volume: 91(10) Pages: 1322-1327

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of TRPA1 activation in acute pain induced by cadmium in mice2013

    • Author(s)
      Miura S, Takahashi K, Imagawa T, Uchida K, Saito S, Tominaga M, Ohta T.
    • Journal Title

      Molecular Pain

      Volume: 9 Pages: 7-7

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of molecular determinants for a potent mammalian TRPA1 antagonist by utilizing species differences.2013

    • Author(s)
      Nakatsuka K, Gupta R, Saito S, Banzawa N, Takahashi K, Tominaga M, Ohta T
    • Journal Title

      J Mol Neurosci

      Volume: 51 Issue: 3 Pages: 754-762

    • DOI

      10.1007/s12031-013-0060-2

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of TRPA1 activation in acute pain induced by cadmium in mice2013

    • Author(s)
      Miura S, Takahashi K, Imagawa T, Uchida K, Saito S, Tominaga M, OhtaT
    • Journal Title

      Molecular Pain

      Volume: 9 Pages: 7-7

    • DOI

      10.1186/1744-8069-9-7

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inflammatory acidic pH enhances hydrogen sulfide-induced TRPA1 activation in RIN-14B cells.2013

    • Author(s)
      Takahashi K
    • Journal Title

      J. Neurosci. Res.

      Volume: 91

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of TRPA1 in Cadimium-induced acute pain in mice.2013

    • Author(s)
      Ohta T
    • Journal Title

      J. Pharmacol. Sci.

      Volume: 121 Pages: 147-147

    • Related Report
      2012 Annual Research Report
  • [Journal Article] External low pH enhances TRPA1-mediated acute pain by hydrogen sulfide.2013

    • Author(s)
      Takahashi K
    • Journal Title

      J. Pharmacol. Sci.

      Volume: 121 Pages: 146-146

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Low pH enhances 2-aminoethoxydiphenyl borate-induced cell death of PC12 cells2012

    • Author(s)
      Takahashi K, Ohta T.
    • Journal Title

      Toxicol Lett

      Volume: 215(7) Pages: 161-166

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of Transient Receptor Potential Ankyrin 1 (TRPA1) in Frogs and Lizards Illuminates Both Nociceptive Heat and Chemical Sensitivities and Coexpression with TRP vanilloid 1 (TRPV1) in Ancestral Vertebrates2012

    • Author(s)
      Saito S, Nakatsuka K, Takahashi K, Fukuta N, Imagawa T, Ohta T, Tominaga M.
    • Journal Title

      J Biol Chem

      Volume: 287(36) Pages: 30743-30754

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] H2S functions as a nociceptive messenger through transient receptor potential ankyrin 1 (TRPA1) activation2012

    • Author(s)
      Ogawa H, Takahashi K, Miura S, Imagawa T, Saito S, Tominaga M, Ohta T
    • Journal Title

      Neuroscience

      Volume: 218 Pages: 335-343

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular Cloning and Functional Characterization of Xenopus Molecular Cloning and Functional Characterization of Xenopus tropicalis Frog Transient Receptor Potential Vanilloid 1 Reveal Its Functional Evolution for Heat, Acid, and Capsaicin Sensitivities in Terrestrial Vertebrates2012

    • Author(s)
      Ohkita M, Saito S, Imagawa T, Takahashi K, Tominaga M, Ohta T.
    • Journal Title

      J Biol Chem

      Volume: 287(4) Pages: 2388-2397

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Low pH enhances 2-aminoethoxydiphenyl borate-induced cell death of PC12 cells.2012

    • Author(s)
      Takahashi K
    • Journal Title

      Toxicol. Lett.

      Volume: 215 Issue: 3 Pages: 161-166

    • DOI

      10.1016/j.toxlet.2012.10.013

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of Transient Receptor Potential Ankyrin 1 (TRPA1) in Frogs and Lizards Illuminates Both Nociceptive Heat and Chemical Sensitivities and Coexpression with TRP vanilloid 1 (TRPV1) in Ancestral Vertebrates.2012

    • Author(s)
      Saito S
    • Journal Title

      J. Biol. Chem.

      Volume: 287 Issue: 36 Pages: 30743-30754

    • DOI

      10.1074/jbc.m112.362194

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] H2S functions as a nociceptive messenger through transient receptor potential ankyrin 1(TRPA1) activation2012

    • Author(s)
      Ogawa H, Takahashi K, Miura S, Imagawa T, Saito S, Tominaga M, Ohta T
    • Journal Title

      Neuroscience

      Volume: (in press) Pages: 335-343

    • DOI

      10.1016/j.neuroscience.2012.05.044

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular Cloning and Functional Characterization of Xenopus tropicalis Frog Transient Receptor Potential Vanilloid 1 Reveal Its Functional Evolution for Heat, Acid, and Capsaicin Sensitivities in Terrestrial2012

    • Author(s)
      Ohkita M, Saito S, Imagawa T, Takahashi K, Tominaga M, Ohta T
    • Journal Title

      Vertebrates. J Biol Chem

      Volume: 287(4) Issue: 4 Pages: 2388-97

    • DOI

      10.1074/jbc.m111.305698

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular cloning and functional characterization of amphibian TRPV1 reveals its functional evolution for polymodal stimuli.2012

    • Author(s)
      Ohkita, M
    • Journal Title

      J. Pharmacol. Sci.

      Volume: 118 Pages: 97-97

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Histamine potentiates acid-induced responses mediating transient receptor potential V1(TRPV1)in mouse primary sensory neurons.2010

    • Author(s)
      Kajihara Y
    • Journal Title

      Neuroscience

      Volume: 166 Pages: 292-304

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased calcium channel currents and facilitated epinephrine release in the Ca^<2+> channel beta3 subunit-null mice.2010

    • Author(s)
      Ohta T.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 394 Pages: 464-469

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adenosine and inosine release during hypoxia in the isolated spinal cord of rats.2010

    • Author(s)
      Takahashi T
    • Journal Title

      Br J Pharmacol.

      Volume: 161 Pages: 1806-1816

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 酸性条件下におけるPC12 細胞の2-aminoethoxydiphenyl borate 誘発性Ca 流入メカニズム2014

    • Author(s)
      高橋賢次, 横田緑苗, 太田利男
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台
    • Year and Date
      2014-03-20
    • Related Report
      2013 Final Research Report
  • [Presentation] リモネンによるTRPA1 チャネルを介した疼痛抑制作用について2014

    • Author(s)
      貝本竜規, 高橋賢次, 斎藤茂, 富永真琴, 太田利男
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台
    • Year and Date
      2014-03-19
    • Related Report
      2013 Final Research Report
  • [Presentation] 熱感受性チャネルとしての鳥類Transient Receptor Potential Ankyrin 1 ( TRPA1 )受容体の機能2013

    • Author(s)
      鴋澤永子, 齋藤茂, 高橋賢次, 富永真琴, 太田利男
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      岐阜
    • Year and Date
      2013-09-20
    • Related Report
      2013 Final Research Report
  • [Presentation] Limonene による鎮痛作用におけるTransient receptor potential ankyrin1 (TRPA1)の関与2013

    • Author(s)
      貝本竜規, 高橋賢次, 富永真琴, 太田利男
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      岐阜
    • Year and Date
      2013-09-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 2-Aminoethyldiphenyl borate(2APB)は酸依存性にストア作動性Ca チャネルOrai3 を活性化する2013

    • Author(s)
      高橋賢次, 横田緑苗, 太田利男
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      岐阜
    • Year and Date
      2013-09-20
    • Related Report
      2013 Final Research Report
  • [Presentation] Cadmium induces acute pain through the activation of nociceptive TRPA1 channel in mice2013

    • Author(s)
      Ohta T, Miura S, Takahashi K, Imagawa T, Uchida K, Saito S, Tominaga M.
    • Organizer
      Neuro2013
    • Place of Presentation
      Kyoto
    • Year and Date
      2013-06-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 2- Aminoethoxydiphenyl borate によるPC12 細胞の酸依存性細胞死誘発作用2013

    • Author(s)
      高橋賢次, 横田緑苗, 太田利男
    • Organizer
      第155回日本獣医学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-30
    • Related Report
      2013 Final Research Report
  • [Presentation] カドミウムによる発痛作用には侵害受容性TRPA1 チャネルが関与する2013

    • Author(s)
      太田利男, 三浦冴子, 高橋賢次, 齋藤茂, 内田邦敏, 富永真琴
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2013-03-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 硫化水素によるTRPA1 を介した発痛作用はアシドーシス条件下で増強される2013

    • Author(s)
      高橋賢次, 小川ひとみ, 齋藤茂, 富永真琴, 太田利男
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2013-03-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Cadmium induces acute pain through the activation of nociceptive TRPA1 channel in mice.2013

    • Author(s)
      Ohta T, Miura S, Takahashi K, Imagawa T, Uchida K, Saito S, Tominaga M
    • Organizer
      Neuro2013
    • Place of Presentation
      京都 国立京都国際会館
    • Related Report
      2013 Annual Research Report
  • [Presentation] ニシツメガエルTransien Receptor Potential Ankyrin1(TRPA1)の遺伝子クローニングと発現・機能解析2012

    • Author(s)
      中塚一将, 齋藤茂, 高橋賢次, 富永真琴, 太田利男
    • Organizer
      第154回日本獣医学会学術集会
    • Place of Presentation
      盛岡
    • Year and Date
      2012-09-15
    • Related Report
      2013 Final Research Report
  • [Presentation] カドミウムによるTransient Receptor Potential Ankyrin1 (TRPA1)を介したマウス知覚神経の興奮作用2012

    • Author(s)
      三浦冴子, 高橋賢次, 富永真琴, 太田利男
    • Organizer
      第154回日本獣医学会学術集会
    • Place of Presentation
      盛岡
    • Year and Date
      2012-09-15
    • Related Report
      2013 Final Research Report
  • [Presentation] 硫化水素のTRPA1チャネル活性化を介した侵害受容メッセンジャーとしての役割「TRP チャネル群の動作原理と生理・病理機能の統合的理解」2012

    • Author(s)
      小川ひとみ, 高橋賢次, 三浦冴子, 齋藤茂, 富永真琴, 太田利男
    • Organizer
      第8回TRPチャネル研究会
    • Place of Presentation
      岡崎
    • Year and Date
      2012-06-14
    • Related Report
      2013 Final Research Report
  • [Presentation] 細胞外酸性下における硫化水素の発痛増強作用とその機構について2012

    • Author(s)
      小川ひとみ, 高橋賢次, 三浦冴子, 太田利男
    • Organizer
      第153回日本獣医学会学術集会
    • Place of Presentation
      大宮
    • Year and Date
      2012-03-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 両生類TRPV1 遺伝子クローニングと機能解析によるポリモーダル感受性の進化2012

    • Author(s)
      大北真嗣, 齋藤茂, 高橋賢次, 富永真琴, 太田利男
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-15
    • Related Report
      2013 Final Research Report
  • [Presentation] 硫化水素はTRPA1 の活性化を介してマウスに疼痛反応を引き起こす2011

    • Author(s)
      小川ひとみ, 高橋賢次, 三浦冴子, 齋藤 茂, 富永真琴, 太田利男
    • Organizer
      第39回薬物活性シンポジウム
    • Place of Presentation
      福岡
    • Year and Date
      2011-11-22
    • Related Report
      2013 Final Research Report
  • [Presentation] 酸性条件下における2-aminoethoxydiphenyl borate によるPC12 細胞の細胞死誘発作用2011

    • Author(s)
      高橋賢次, 太田利男
    • Organizer
      第64回日本薬理学会西南部会
    • Place of Presentation
      福岡
    • Year and Date
      2011-11-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 硫化水素によるTRPA1受容体を介したマウス知覚神経の活性化2011

    • Author(s)
      小川ひとみ, 高橋賢次, 三浦冴子, 齋藤 茂, 富永真琴, 太田利男
    • Organizer
      第152回日本獣医学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2011-09-20
    • Related Report
      2013 Final Research Report
  • [Presentation] ニシツメガエルTransient receptor potential vanilloid1は侵害刺激を受容する2011

    • Author(s)
      大北真嗣, 齋藤 茂, 富永真琴, 高橋賢次, 今川敏明, 太田利男
    • Organizer
      第7回TRP チャネル研究会
    • Place of Presentation
      岡崎
    • Year and Date
      2011-06-20
    • Related Report
      2013 Final Research Report
  • [Presentation] Change in intracellular Ca2+ concentration induced by hydrogen sulfide in mouse sensoryneurons2011

    • Author(s)
      小川ひとみ
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-03-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] マウス知覚神経における硫化水素による細胞内Ca 増加反応について2011

    • Author(s)
      小川ひとみ, 高橋賢次, 齋藤 茂, 富永真琴, 太田利男
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-22
    • Related Report
      2013 Final Research Report
  • [Presentation] Facilitated epinephrine release in the calcium channel B3 subunit-null mice2011

    • Author(s)
      村上学
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-03-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Decreased calcium channel currents and facilitated epinephrine release in the calcium channel beta3 subunit-null mice.2010

    • Author(s)
      M.MURAKAMI
    • Organizer
      Neuroscience 2010
    • Place of Presentation
      サンディエゴ(米国)
    • Year and Date
      2010-11-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Xenopus Tropicalis TRPV1遺伝子クローニングと発現・機能解析2010

    • Author(s)
      大北真嗣
    • Organizer
      第150回日本獣医学会学術集会
    • Place of Presentation
      帯広畜産大学(北海道)
    • Year and Date
      2010-09-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 酸性条件下におけるPC12細胞の2-aminoethoxydiphenyl borate誘発性Ca流入メカニズム

    • Author(s)
      高橋賢次、横田緑苗、太田利男
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台国際センター
    • Related Report
      2013 Annual Research Report
  • [Presentation] リモネンによるTRPA1チャネルを介した疼痛抑制作用について

    • Author(s)
      貝本竜規、高橋賢次、斎藤茂、富永真琴、太田利男
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台国際センター
    • Related Report
      2013 Annual Research Report
  • [Presentation] ツメガエルの温度環境適応に関連した高温受容体 TRPV1 チャネル特性の種間差とその分子基盤

    • Author(s)
      齋藤 茂、大北 真嗣、齋藤 くれあ、福田 直美、太田 利男、富永 真琴
    • Organizer
      第 91 回 日本生理学会大会
    • Place of Presentation
      鹿児島大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 熱感受性チャネルとしての鳥類Transient Receptor Potential Ankyrin 1( TRPA1 )受容体の機能

    • Author(s)
      鴋澤 永子、齋藤 茂、高橋 賢次、富永 真琴、太田 利男
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      岐阜大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] Limoneneによる鎮痛作用におけるTransient receptor potential ankyrin1(TRPA1)の関与

    • Author(s)
      貝本 竜規、高橋 賢次、富永 真琴、太田 利男
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      岐阜大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 2-Aminoethyldiphenyl borate(2APB)は酸依存性にストア作動性CaチャネルOrai3を活性化する

    • Author(s)
      高橋 賢次、横田 緑苗、太田 利男
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      岐阜大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 侵害性の温度・化学物質受容体 TRPA1チャネルの機能的な種間多様性とその分子基盤

    • Author(s)
      齋藤 茂、鴋澤永子、福田直美、太田利男、富永真琴
    • Organizer
      温熱生理研究会
    • Place of Presentation
      岡崎バイオサイエンスセンター
    • Related Report
      2013 Annual Research Report
  • [Presentation] 2-Aminoethoxydiphenyl borateによるPC12細胞の酸依存性細胞死誘発作用

    • Author(s)
      高橋賢次
    • Organizer
      第155回日本獣医学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] カドミウムによる発痛作用には侵害受容性TRPA1チャネルが関与する

    • Author(s)
      太田利男
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] 硫化水素によるTRPA1を介した発痛作用はアシドーシス条件下で増強される

    • Author(s)
      高橋賢次
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] ニシツメガエルTransien Receptor Potential Ankyrin1(TRPA1)の遺伝子クローニングと発現・機能解析

    • Author(s)
      中塚一将
    • Organizer
      第154回日本獣医学会学術集会
    • Place of Presentation
      盛岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] カドミウムによるTransient Receptor Potential Ankyrin1 (TRPA1)を介したマウス知覚神経の興奮作用

    • Author(s)
      三浦冴子
    • Organizer
      第154回日本獣医学会学術集会
    • Place of Presentation
      盛岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] 硫化水素のTRPA1チャネル活性化を介した侵害受容メッセンジャーとしての役割

    • Author(s)
      太田利男
    • Organizer
      生理学研究所TRP研究会
    • Place of Presentation
      岡崎
    • Related Report
      2012 Annual Research Report
  • [Presentation] 細胞外酸性下における硫化水素の発痛増強作用とその機構について

    • Author(s)
      小川 ひとみ
    • Organizer
      第153回日本獣医学会学術集会
    • Place of Presentation
      大宮ソニックシティ(埼玉県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 両生類TRPV1遺伝子クローニングと機能解析によるポリモーダル感受性の進化

    • Author(s)
      大北真嗣
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 硫化水素はTRPA1の活性化を介してマウスに疼痛反応を引き起こす

    • Author(s)
      太田利男
    • Organizer
      第39回薬物活性シンポジウム
    • Place of Presentation
      福岡大学メディカルホール(福岡県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 酸性条件下における2-aminoethoxydiphenyl borateによるPC12細胞の細胞死誘発作用

    • Author(s)
      高橋賢次
    • Organizer
      第64回日本薬理学会西南部会
    • Place of Presentation
      KKRホテル博多(福岡県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] ニシツメガエルTransient receptor potential vanilloid1は侵害刺激を受容する

    • Author(s)
      大北真嗣
    • Organizer
      第7回TRPチャネル研究会
    • Place of Presentation
      岡崎統合バイオサイエンスセンター(愛知県)
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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