| Budget Amount *help |
¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Research Abstract |
There are carcinogens that can induce karyomegaly reflecting cell cycle aberration in carcinogenic target cells. In this study, we found that carcinogens evoking facilitation of cell proliferation increased apoptosis and M phase-disrupting cells in the carcinogenic target organs after28-day treatment in rats, and thus, we obtained candidates for early prediction markers ofcarcinogenicity. We also found that tumor promotion with karyomegaly-inducing hepatocarcinogens may cause disruption of cell cycle regulation through epigenetic gene modification of p16^Ink4a in the carcinogenic process from the early stage.
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