Study on pathogenesis and transmission of animal AA amyloidosisandtheir enhancing factors
| Project/Area Number |
22380165
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied veterinary science
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| Research Institution | Gifu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
INOSHIMA Yasuo 岐阜大学, 応用生物科学部, 准教授 (20355184)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUI Takane 帯広畜産大学, 畜産学部, 教授 (40111116)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2010: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Keywords | 疾病予防 / 制御 / ウシ / ニワトリ / ウサギ / アミロイド / 伝播 / 伝播性 / アイソフォーム / 伝達性 / モノクローナル抗体 / 血清アミロイドA蛋白質 |
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| Research Abstract |
Amyloid A (AA) amyloidosis is induced in animals with high plasma concentration of precursor serum amyloid protein A (SAA), and characterized by the extracellular deposition of AA proteins in different organs and tissues. AA amyloidosis is observed by mainly in cows and table birds. In this study,several tissues from AA amyloidosis affected cows and chickens were histologically examined, and the transmission mechanism of AA amyloidosis was analyzed using chicken and rabbit models. Bovine AA amyloidosis was classified by two types Class I of typical and Class II of atypical amyloidosis by amyloid deposition and clinical symptoms. BovineAA amyloid developed experimental AA amyloidosis in rabbits. We observed fatal outbreaks of AA amyloidosis in white hens inoculated by vaccine. Chicken AA amyloidosis was shown to be transmitted within same species inoculated with vaccine and chicken amyloid.
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Report
(4 results)
Research Products
(17 results)
