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The role of Chlamydia psittaci polymorphic membrane proteins (pmp) in its pathogenesis and in determination of host range.

Research Project

Project/Area Number 22380166
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied veterinary science
Research InstitutionGifu University

Principal Investigator

OHYA Kenji  岐阜大学, 応用生物科学部, 准教授 (50402219)

Co-Investigator(Kenkyū-buntansha) FUKUSHI Hideto  岐阜大学, 応用生物科学部, 教授 (10156763)
Co-Investigator(Renkei-kenkyūsha) OKUDA Hideko  岐阜大学, 大学院連合獣医学研究科, 博士 課程大学院生
HARASAKI Tayo  岐阜大学, 応用生物科学部, 学部学生
Project Period (FY) 2010-04-01 – 2013-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2011: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2010: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Keywords人獣共通感染症 / 細胞内寄生細菌 / クラミジア / オウム病 / 外膜蛋白質 / 病原性 / 疫学 / 細胞内寄生性細菌 / 比較ゲノム
Research Abstract

Chlamydia psittaci, an obligate intracellular bacterium, is an etiological agent for human psittacosis. In this project, regarding chlamydial pathogenesis and diverse host range, we have focused on the role of the polymorphic membrane protein (pmp) family of C. psittaci. The representative results were as follows. 1) Comparative genomics of the pmp family: Diversity of the pmp family genes were observed in the genomes of intra-chlamydial strains as well as inter-chlamydial species. 2) Expression profile of the Pmp family during growth of C. psittaci: In addition to the constitutively expressed Pmp (e.g.: PmpD), some Pmp (such as PmpG11) were transcribed after the mid-stage of the chlamydial propagation in host cells. 3) Functional analysis of the C. psittaci-specific Pmp: Regarding to the C. psittaci-specific PmpG11, although its contribution to the chlamydial pathogenesis was unknown, the applicability of PmpG11 as a serodiagnostic antigen was revealed and evaluated.

Report

(4 results)
  • 2013 Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (35 results)

All 2013 2012 2011 2010 Other

All Journal Article (16 results) (of which Peer Reviewed: 11 results) Presentation (16 results) (of which Invited: 1 results) Book (3 results)

  • [Journal Article] オウム病2013

    • Author(s)
      福士秀人,大屋賢司
    • Journal Title

      小児科

      Volume: 54 Pages: 57-63

    • URL

      http://www.kanehara-shuppan.co.jp/journal/detail.html?kubun=04751&code=047512013010&hakkou_nengetsu=201301

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Journal Article] Relatedness between Host Species and Genotype of Beak and Feather Disease Virus Suggesting Possible Interspecies Cross Infection during Bird Trade2013

    • Author(s)
      Ogawa H, Chahota R, Ohya K, Yamaguchi T, Fukushi H
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 75 Issue: 4 Pages: 503-507

    • DOI

      10.1292/jvms.12-0367

    • NAID

      130002502210

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genomic sequence of an infectious bursal disease virus isolate from Zambia: classical attenuated segment B reassortment in nature with existing very virulent segment A2013

    • Author(s)
      Kasanga CJ, Yamaguchi T, Munang'andu HM, Ohya K, Fukushi H
    • Journal Title

      Arch. Virol.

      Volume: 158 Issue: 3 Pages: 685-689

    • DOI

      10.1007/s00705-012-1531-4

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genomic sequence of infectious bursal disease virus from Zambia suggests evidence for genome re-assortment in nature.2013

    • Author(s)
      Kasanga CJ, Yamaguchi T, Munang'andu HM, Wambura PN, Ohya K, Fukushi H
    • Journal Title

      Onderstepoort J Vet Res.

      Volume: 79

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Complete genome sequence of equine herpesvirus type 9 (EHV-9)2012

    • Author(s)
      Fukushi H, Yamaguchi T, Yamada S
    • Journal Title

      J. Virol

      Volume: 86 Issue: 24 Pages: 13822-13822

    • DOI

      10.1128/jvi.02607-12

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of Chlamydophila psittaci by Using SYBR Green Real-Time PCR2011

    • Author(s)
      Okuda H, Ohya K, Shiota Y, Kato H, Fukushi H
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 73 Issue: 2 Pages: 249-254

    • DOI

      10.1292/jvms.10-0222

    • NAID

      130000444136

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] オウム病クラミジア集団発生事例分離株ゲノム配列決定とその意義2011

    • Author(s)
      大屋賢司,黒田誠,関塚剛史, Garry MEYERS,岸本寿男,安藤秀二,奥田秀子,福士秀人
    • Journal Title

      獣医畜産新報

      Volume: 64 Pages: 804-806

    • URL

      https://buneido-shuppan.com/?gloc_id=03001&bkcd=2011105001

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Journal Article] コクシエラ・クラミジア感染症2011

    • Author(s)
      福士秀人
    • Journal Title

      最新医学

      Volume: 66 Pages: 2703-2712

    • URL

      http://www.saishin-igaku.co.jp/backnum/2011/m6612.html

    • Related Report
      2013 Final Research Report
  • [Journal Article] Functional characterization of EUL47 in productive replication, morphogenesis and infectivity of equine herpesvirus 12011

    • Author(s)
      Yu MH, Kasem S, Yoshizaki N, Pagamjav O, Yamaguchi T, Ohya K, Fukushi H
    • Journal Title

      Virus Research

      Volume: 163 Issue: 1 Pages: 310-319

    • DOI

      10.1016/j.virusres.2011.10.021

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of Chlamydophila psittaci by Using SYBR Green Real-Time PCR.2011

    • Author(s)
      Okuda H
    • Journal Title

      J. Vet. Med. Sci.

      Volume: 73 Pages: 249-254

    • NAID

      130000444136

    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epidemiology of Chlamydophila caviae-like Chlamydia isolated from urethra and uterine cervix2010

    • Author(s)
      Murao W, Wada K, Matsumoto A, Fujiwara M, Fukushi H, Kishimoto T, Monden K, Kariyama R, Kumon H
    • Journal Title

      Acta Med. Okayama

      Volume: 64 Pages: 1-9

    • NAID

      120002311602

    • URL

      http://escholarship.lib.okayama-u.ac.jp/amo/vol64/iss1

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Review of DNA Viral Infections in Psittacine Birds2010

    • Author(s)
      Katoh H, Ogawa H, Ohya K, Fukushi H
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 72 Issue: 9 Pages: 1099-1106

    • DOI

      10.1292/jvms.10-0022

    • NAID

      130000264240

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Using CF0218-ELISA to distinguish Chlamydophila felis-infected cats from vaccinated and uninfected domestic cats2010

    • Author(s)
      Ohya K, Okuda H, Maeda S, Yamaguchi T, Fukushi H
    • Journal Title

      Vet. Microbiol

      Volume: 146 Issue: 3-4 Pages: 366-370

    • DOI

      10.1016/j.vetmic.2010.05.026

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Using CF0218-ELISA to distinguish Chlamydophila felis-infected cats from vaccinated and uninfected domestic cats.2010

    • Author(s)
      Ohya Kenji
    • Journal Title

      Vet. Microbiol.

      Volume: 146 Pages: 366-370

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epidemiology of Chlamydophila caviae-like Chlamydia isolated from urethra and uterine cervix.2010

    • Author(s)
      Murao Wataru
    • Journal Title

      Acta Med. Okayama

      Volume: 64 Pages: 1-9

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 鳥類のクラミジア感染症2010

    • Author(s)
      福士秀人
    • Journal Title

      INK plus

      Volume: 8 Pages: 8-9

    • Related Report
      2010 Annual Research Report
  • [Presentation] オウム病クラミジアとその感染症における現状と課題2013

    • Author(s)
      福士秀人
    • Organizer
      日本細菌学会
    • Place of Presentation
      千葉
    • Year and Date
      2013-03-18
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Presentation] オウム病の理解と制御に向けたとりくみ?ゲノム情報を利用した診断法開発と実態調査2012

    • Author(s)
      大屋賢司
    • Organizer
      戦略的研究基盤形成支援事業「人獣共通感染症の戦略的国際疫学研究の推進と若手研究者の実践的育成」平成24年度シンポジウム
    • Place of Presentation
      藤沢
    • Year and Date
      2012-12-08
    • Related Report
      2013 Final Research Report
  • [Presentation] ガーナ共和国における野鳥のChlamydia属菌保有状況調査2012

    • Author(s)
      奥田秀子
    • Organizer
      日本獣医学会
    • Place of Presentation
      盛岡
    • Year and Date
      2012-09-15
    • Related Report
      2013 Final Research Report
  • [Presentation] オウム病クラミジアのゲノム解析2012

    • Author(s)
      大屋賢司
    • Organizer
      動物クラミジアを検出するLAMP法の開発
    • Place of Presentation
      盛岡
    • Year and Date
      2012-09-15
    • Related Report
      2013 Final Research Report
  • [Presentation] クラミジア肺炎およびオウム病を鑑別するマルチプレックスPCR法の開発2012

    • Author(s)
      原崎多代
    • Organizer
      日本獣医学会
    • Place of Presentation
      盛岡
    • Year and Date
      2012-09-15
    • Related Report
      2013 Final Research Report
  • [Presentation] ガーナ共和国におけるChlamydia属菌保有状況調査2012

    • Author(s)
      奥田秀子
    • Organizer
      日本獣医学会
    • Place of Presentation
      岩手
    • Related Report
      2012 Annual Research Report
  • [Presentation] Chlamydia psittaci specific genes, which are identified by comparative genomic analysis, can be used for differential diagnosis of chlamydia species2011

    • Author(s)
      Ohya K
    • Organizer
      International Union of Microbiological Societies Congress
    • Place of Presentation
      Sapporo
    • Year and Date
      2011-09-08
    • Related Report
      2013 Final Research Report
  • [Presentation] Genome sequence of the zoonotic pathogen, Chlamydia psittaci2011

    • Author(s)
      Ohya K
    • Organizer
      Chlamydia basic society meeting
    • Place of Presentation
      California
    • Year and Date
      2011-03-20
    • Related Report
      2013 Final Research Report
  • [Presentation] Genome sequence of the zoonotic pathogen, Chlamydia psittaci.2011

    • Author(s)
      Kenji Ohya
    • Organizer
      The 5th Chlamydia Basic Research Society Meeting
    • Place of Presentation
      California, USA
    • Year and Date
      2011-03-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 鑑別診断法開発と病態解明を目指して2011

    • Author(s)
      大屋賢司
    • Organizer
      日本獣医師会学術集会
    • Place of Presentation
      岐阜
    • Year and Date
      2011-02-12
    • Related Report
      2013 Final Research Report
  • [Presentation] オウム病クラミジアのゲノム解析:鑑別診断法開発と病態解明を目指して2011

    • Author(s)
      大屋賢司
    • Organizer
      平成22年度日本獣師会学術学会年次大会
    • Place of Presentation
      岐阜
    • Year and Date
      2011-02-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] Rapid Multiplex PCR Assay for simultaneous Detection of Chlamydophila causing abortion in ruminants.2011

    • Author(s)
      Ibrahim RABIA
    • Organizer
      第152回 日本獣医学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2011 Annual Research Report
  • [Presentation] Chlamydia psittaci specific genes, which are identified by comparative genomic analysis, can be used for differential diagnosis of chlamydia species.2011

    • Author(s)
      Kenji OHYA
    • Organizer
      International Union of Microbiological Societies Congress
    • Place of Presentation
      札幌
    • Related Report
      2011 Annual Research Report
  • [Presentation] オウム病クラミジア集団発生事例分離株の全ゲノム配列決定2010

    • Author(s)
      大屋賢司
    • Organizer
      第10回人と動物の共通感染症研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 日本国内における鳥類のオウム病クラミジアの保菌調査2010

    • Author(s)
      奥田秀子
    • Organizer
      第150回日本獣医学会学術集会
    • Place of Presentation
      帯広
    • Year and Date
      2010-09-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] オウム病の理解と制御に向けたとりくみ~ゲノム情報を利用した診断法開発と実態調査

    • Author(s)
      大屋賢司
    • Organizer
      戦略的研究基盤形成支援事業「人獣共通感染症の戦略的国際疫学研究の推進と若手研究者の実践的育成」平成24 年度シンポジウム
    • Place of Presentation
      藤沢
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] 獣医微生物学「リケッチア」2011

    • Author(s)
      大屋賢司,福士秀人
    • Publisher
      文永堂(第3版,見上彪監修)
    • Related Report
      2013 Final Research Report
  • [Book] 獣医微生物学「クラミジア」2011

    • Author(s)
      大屋賢司,福士秀人
    • Publisher
      文永堂(第3版,見上彪監修)
    • Related Report
      2013 Final Research Report
  • [Book] 獣医微生物学(第3版)2011

    • Author(s)
      大屋賢司
    • Publisher
      文永堂
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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