|Budget Amount *help
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2013: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
We found genetic diversity in FeLV env genes. Phylogenetic tree indicated that FeLV samples were separated into three distinct genetic clusters. A novel recombinant virus, termed FeLV-D, was generated ERV-DC env transduction into FeLV. ERV-DCs are present and hereditary in the domestic cat genome. Two of these ERV-DCs, ERV-DC10 and ERV-DC18 are replication-competent gammaretroviruses. Insertional polymorphism analysis revealed that 38% of domestic cats had ERV-DC10. ERV-DCs behave as donors and/or acceptors in the generation of infectious, recombinant viruses. Furthermore, we discovered a soluble anti-retroviral factor, termed Refrex-1. The host retains Refrex-1 as an anti-retroviral factor which may potentially prevent re-emergence of ERVs and emergence of novel ERV-related viruses in cats. We provide an exciting and unique system in cats to study retrovirus-host coevolution and establish paleovirology in cats.