Structural protective effects of glycosaminoglycans on articular distraction in joint diseases in animals
| Project/Area Number |
22380170
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Clinical veterinary science
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| Research Institution | Hokkaido University |
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Principal Investigator |
OKUMURA Masahiro 北海道大学, 大学院・獣医学研究科, 教授 (80260397)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAGI Satoshi 北海道大学, 大学院・獣医学研究科, 准教授 (50396305)
HOSOYA Kenji 北海道大学, 大学院・獣医学研究科, 助教 (50566156)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2012: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2011: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2010: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
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| Keywords | 関節疾患 / グリコサミノグリカン軟骨細胞 / 滑膜細胞 / グリコサミノグリカン / 軟骨細胞 |
|---|
| Research Abstract |
Intra-articular hyaluronic acid (HA) and subcutaneous pentosan polysulfate sodium (PPS) have been used for the management of pain and inflammation of osteoarthritis (OA) in humans and animals. As the results of this study, it was indicated that exogenous HA could stimulates both synovial fibroblasts and chondrocytes to produce endogenous long chain HA which contribute stabilization of cellular environment of articular chondrocytes. It was also suggested that PPS could inhibit interleukin (IL)-1β-induced phosphorylation of p38 and extracellular signal-regulated kinase (ERK), then suppress nuclear translocation of NF-κB and matrix metalloproteinase-3 production in cultured chondrocytes. on interleukin (IL)-1β stimulated chondrocytes. These data would translate the clinical efficacy of these molecules for clinical chondroprotective effects of HA and PPS in animals with OA.
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Report
(4 results)
Research Products
(29 results)
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[Presentation] 小動物の関節疾患2011
Author(s)
奥村正裕
Organizer
第32回動物臨床医学会
Place of Presentation
大阪国際会議場(大阪市)
Year and Date
2011-11-20
Related Report
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[Presentation] 犬の関節疾患2010
Author(s)
奥村正裕
Organizer
動物臨床医学会
Place of Presentation
大阪国際会議場(大阪府)
Year and Date
2010-11-20
Related Report
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[Presentation] 犬の関節疾患2010
Author(s)
奥村正裕
Organizer
動物臨床医学会
Place of Presentation
大阪国際会議場(大阪府) 招待講演
Year and Date
2010-11-20
Related Report
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