| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2012: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2010: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Research Abstract |
Allergen-specific immunotherapy (SIT) is the only promising treatment of allergic disorders, but current SIT has problems such as the risk of side effects. Objective of this study is to construct a recombinant house dust mite allergen library, and to apply those allergen molecules for the development of molecular diagnostics and immunotherapeutics. Here, we showed a successful and comprehensive production of 23 major house dust mite allergens as a functional recombinant proteins. By using those recombinant allergen molecules, we also developed a molecular diagnostic system that enabled us to determine sensitized allergens among mite-allergic individuals.
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