| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2012: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Research Abstract |
Enantioselective Meerwein-Ponndorf-Verley type reduction of alkynoylsilanes by a chiral lithium amide followed by a Brook rearrangement and SE2’ electrophilic substitution leads to the formation of enantiomerically enriched functionalized siloxyallenes in a one-pot process. In the case of enynoylsilanes, generated vinylallenes undergo in situ [4 + 2] cycloaddition to afford highly functionalized polycyclic compounds in excellent er’s, which show unusual facial selectivity.
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