Development and Application of Highly Stereoselective Aldol Reactions Using Chiral Amide

• Project/Area Number: 22390004
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Chemical pharmacy
• Research Institution: Tokyo University of Science
• Principal Investigator: KOBAYASHI Susumu 東京理科大学, 薬学部, 教授 (70101102)
• Co-Investigator(Renkei-kenkyūsha): SUZUKI Takahiro 東京理科大学, 薬学部, 助教 (80367052)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000); Fiscal Year 2012: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2011: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2010: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
• Keywords: 合成化学 / 天然物合成 / キラルイミド / ビニロガス向山アルドール反応 / 1,2-ジオール / 全合成 / インセンソールアセテート / マイクサラミド / メチノリド / ピニロガス向山アルドール反応 / イソセンソールアセテート / フォミテリン酸B / TMC-151C / α-ハロエナール / ナフレジン-γ

Research Abstract

Diastereoselective reactions using chiral amide have extensively been utilized in the chiral synthesis of complex molecules in these decades.In this context, we have developed two types of diastereoselective aldol reactions. In the present investigation, we focused on (1) further improvement of vinylogous Mukaiyama aldol reaction, (2) general applicability of the stereocontrol of 1,2-diol including tertiary alcohol, and (3) application to biologically significant naturally occurring compounds.

Research Products

• [Journal Article] Unexpected Diels-Alder/Carbonylene Cascade toward the Biomimetic Synthesis of Chloropupukeananin (2013)
  • Author(s): T. Suzuki, Y. Miyajima, K. Suzuki, K. Iwakiri, M. Koshimizu, G. Hirai, M. Sodeoka, S.Kobayashi
  • Journal Title: Organic Letters Volume: 15 Issue: 7 Pages: 1748-1751
  • DOI: 10.1021/ol400549q
  • Peer Reviewed
• [Journal Article] Design, synthesis, and structure-activity relationships of a series of 4-benzyl-5-isopropyl-1H-pyrazol-3-yl -D-glycopyranosides substituted with novel hydrophilic groups as highly potent inhibitors of sodium glucose co-transporter 1 (SGLT1) (2013)
  • Author(s): N. Fushimi, H. Teranishi, K. Shimizu, S. Yonekubo, K. Ohno, T. Miyagi, F. Itoh, T. Shibazaki, M. Tomae, Y. Ishikawa-Takemura, T. Nakabayashi, N. Kamada, Y. Yamauchi, S. Kobayashi, M. Isaji
  • Journal Title: Bioorganic & Medicinal Chemistry Volume: 21 Issue: 3 Pages: 748-765
  • DOI: 10.1016/j.bmc.2012.11.041
  • Peer Reviewed
• [Journal Article] Synthetic Study of Pyrrocidines: First Entry to the Decahydrofluorene Core of Pyrrocidines (2012)
  • Author(s): R. Tanaka, K. Ohishi, N. Takanashi, T.Nagano, H. Suizu, T. Suzuki, S. Kobayashi
  • Journal Title: Organic Letters Volume: 14 Issue: 18 Pages: 4886-4889
  • DOI: 10.1021/ol3022116
  • Peer Reviewed
• [Journal Article] Concise Total Synthesis of (-)-Myxalamide A (2012)
  • Author(s): K. Fujita, R. Matsui, T. Suzuki, S. Kobayashi
  • Journal Title: Angewandte Chemie Int. Ed. Volume: 51 Issue: 29 Pages: 7271-7274
  • DOI: 10.1002/anie.201203093
  • Peer Reviewed
• [Journal Article] Determination of the Absolute Structure of (+)-Akaterpin (2012)
  • Author(s): H. Hosoi, N. Kawai, H. Hagiwara, T. Suzuki, A. Nakazaki, K. Takao, K. Umezawa, S.Kobayashi
  • Journal Title: Chemical and Pharmaceutical Bulletin Volume: 60 Issue: 1 Pages: 137-143
  • DOI: 10.1248/cpb.60.137
  • NAID: 130001852337
  • ISSN: 0009-2363, 1347-5223
  • Peer Reviewed
• [Journal Article] Pharmacological evaluation of a novel cyclic phosphatidic acid derivative 3-S-cyclic phosphatidic acid (3-S-cPA) (2012)
  • Author(s): Emi Nozaki, Mari Gotoh, Ryo Tanaka, Masaru Kato, Takahiro Suzuki, Atsuo Nakazaki, Harumi Hotta, Susumu Kobayashi, Kimiko Murakami-Murofushi
  • Journal Title: Bioorganic & Medicinal Chemistry Volume: 20 Issue: 10 Pages: 3196-3201
  • DOI: 10.1016/j.bmc.2012.03.060
  • Peer Reviewed
• [Journal Article] Stereocontrolled Synthesis of Functionalized Spirocyclic Compounds based on Claisen Rearrangement and its Application to the Synthesis of Spirocyclic Sesquiterpenes and Pyrrolidinoindoline Alkaloids (2012)
  • Author(s): Atsuo Nakazaki, Susumu Kobayashi
  • Journal Title: Synlett Volume: 23 Issue: 10 Pages: 1427-1445
  • DOI: 10.1055/s-0031-1290982
  • Peer Reviewed
• [Journal Article] Neoechinulin A Imparts Resistance to Acute Nitrosative Stress in PC12 Cells: A Potential Link of an Elevated Cellular Reserve Capacity for Pyridine Nucleotide Redox Turnover with Cytoprotection (2012)
  • Author(s): S. Akashi, K. Shirai, T. Okada, K. Konishi, T. Takeuchi, K. Kuramochi, M. Takahashi, T. Nakagawa, Y. Ogura, S. Fujieda, Y. Shibata, F. Sugawara, S. Kobayashi, N. Watanabe, T. Arai
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 35 Issue: 7 Pages: 1105-1117
  • DOI: 10.1248/bpb.b12-00055
  • NAID: 130001872114
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed
• [Journal Article] Exploration of the binding proteins of perfluorooctane sulfonate by a T7 phage display screen (2012)
  • Author(s): Miyano Y, Tsukuda S, Sakimoto I, Takeuchi R, Shimura S, Takahashi N, Kusayanagi T, Takakusagi Y, Okado M, Matsumoto Y, Takakusagi K, Takeuchi T, Kamisuki S, Nakazaki A, Ohta K, Miura M, Kuramochi K, Mizushina Y, Kobayashi S, Sugawara F, Sakaguchi K.
  • Journal Title: Bioorg. Med. Chem. Volume: 20 Issue: 13 Pages: 3985-3990
  • DOI: 10.1016/j.bmc.2012.05.016
  • Peer Reviewed
• [Journal Article] The antitumor agent doxorubicin binds to Fanconi anemia group F protein (2012)
  • Author(s): Kusavanagi T, Tsukuda S, Shimura S, Manita D, Iwakiri K, Kamisuki S, Takakusagi Y, Takeuchi T, Kuramochi K, Nakazaki A, Sakaguchi K, Kobayashi S, Sugawara F
  • Journal Title: Bioorg. Med. Chem. Volume: 20 Issue: 21 Pages: 6248-6255
  • DOI: 10.1016/j.bmc.2012.09.015
  • Peer Reviewed
• [Journal Article] Structure-activity relationship studies of 4-benzyl-1H-pyrazol-3-yl b-D-glucopyranoside derivatives as potent and selective sodium glucose co-transporter 1 (SGLT1) inhibitors with therapeutic activity on postprandial hyperglycemia (2012)
  • Author(s): N. Fushimi, S. Kobayashi, M. Isaji, 他17名
  • Journal Title: Bioorganic & Medicinal Chemistry Volume: 20 Issue: 22 Pages: 6598-6612
  • DOI: 10.1016/j.bmc.2012.09.037
  • Peer Reviewed
• [Journal Article] A Synthetic Study of Atropurpuran: Construction of a Pentacyclic Framework by an Intramolecular Reverse-Electron-Demand Diels-Alder Reaction (2011)
  • Author(s): T. Suzuki, A. Sasaki, N. Egashira, S.Kobayashi
  • Journal Title: Angewandte Chemie Int. Ed. Volume: 50 Issue: 39 Pages: 9177-9179
  • DOI: 10.1002/anie.201103950
  • Peer Reviewed
• [Journal Article] Synthesis and determination of the relative structure of akaterpin, a potent inhibitor of PI-PLC (2011)
  • Author(s): H. Hosoi, N. Kawai, H. Hagiwara, T. Suzuki, A. Nakazaki, K. Takao, K. Umezawa, S.Kobayashi
  • Journal Title: Tetrahedron Letters Volume: 52 Issue: 38 Pages: 4961-4964
  • DOI: 10.1016/j.tetlet.2011.07.079
  • Peer Reviewed
• [Journal Article] Different Modes of Cyclization in Zoanthamine Alkaloid System, Bisaminal versus Spiroketal Formation (2011)
  • Author(s): T. Nakajima, D. Yamashita, K. Suzuki, A.Nakazaki, T. Suzuki, S. Kobayashi
  • Journal Title: Organic Letters Volume: 13 Issue: 12 Pages: 2980-2983
  • DOI: 10.1021/ol200486c
  • Peer Reviewed
• [Journal Article] Stereoselective Vinylogous Mukaiyama Aldol Reaction of .ALPHA.-Haloenals (2011)
  • Author(s): Y. Iwasaki, R. Matsui, T. Suzuki, A. Nakazaki, S. Kobayashi;
  • Journal Title: Chemical and Pharmaceutical Bulletin Volume: 59 Issue: 4 Pages: 522-524
  • DOI: 10.1248/cpb.59.522
  • NAID: 130000648979
  • ISSN: 0009-2363, 1347-5223
  • Peer Reviewed
• [Journal Article] The second generation synthesis of (+)-pseudodeflectusin (2011)
  • Author(s): Y. Sato, K. Kuramochi, T. Suzuki, A.Nakazaki, S. Kobayashi
  • Journal Title: Tetrahedron Letters Volume: 52 Issue: 5 Pages: 626-629
  • DOI: 10.1016/j.tetlet.2010.11.153
  • Peer Reviewed
• [Journal Article] Convergent Total Synthesis of (+)-TMC-151C Using Vinylogous Mukaiyama Aldol Reaction and Ring-Closing Metathesis (2011)
  • Author(s): R. Matsui, K. Seto, Y. Sato, T. Suzuki, A.Nakazaki, S. Kobayashi
  • Journal Title: Angewandte Chemie Int. Ed. Volume: 50 Issue: 3 Pages: 680-683
  • DOI: 10.1002/anie.201006230
  • Peer Reviewed
• [Journal Article] Total Synthesis of (+)-Nafuredin-γ Using a Highly Stereoselective Ti-mediated Aldol Reaction (2011)
  • Author(s): Y. Onodera, T. Suzuki, S. Kobayashi
  • Journal Title: Organic Letters Volume: 13 Issue: 1 Pages: 50-53
  • DOI: 10.1021/ol102501k
  • Peer Reviewed
• [Journal Article] Synthesis of enantiopure 2-carba-cyclic phosphatidic acid and effects of its chirality on biological functions (2011)
  • Author(s): 野崎絵美、後藤真理、堀田晴美、花澤修和、森博敏、小林進、室伏きみ子
  • Journal Title: Biochimica et Biopysica Acta-Molecular ana Cell Biology of Lipids Volume: 1881 Issue: 4 Pages: 271-277
  • DOI: 10.1016/j.bbalip.2011.01.003
  • Peer Reviewed
• [Journal Article] Cyclosporin A Associated Helicase-Like Protein Facilitates the Association of Hepatitis C Virus RNA Polymerase with Its Cellular Cyclophilin B (2011)
  • Author(s): 諸橋謙吾、佐原広益、小林進、坂口謙吾、菅原二三男
  • Journal Title: PLoS ONE Volume: 6 Issue: 4 Pages: 18285-18285
  • DOI: 10.1371/journal.pone.0018285
  • Peer Reviewed
• [Journal Article] A Possible Mechanism of Cholesteryl Glucoside Formation Involved in Heat Shock Response in the Animal Cell Membrane (2011)
  • Author(s): 秋山央子、浜田勉、長塚康子、小林進、平林良雄、室伏きみ子
  • Journal Title: CYTOLOGIA Volume: 76 Issue: 1 Pages: 19-25
  • DOI: 10.1508/cytologia.76.19
  • NAID: 130004448097
  • ISSN: 0011-4545, 1348-7019
  • Peer Reviewed
• [Journal Article] Comparison of Inhibitory Activities of Stereo-Isomers of Cyclic Phosphatidic Acid (cPA) on Autotaxin (2011)
  • Author(s): 野崎絵美、後藤真理、花澤修和、森博敏、小林進、室伏きみ子
  • Journal Title: CYTOLOGIA Volume: 76 Issue: 1 Pages: 73-80
  • DOI: 10.1508/cytologia.76.73
  • NAID: 130004448106
  • ISSN: 0011-4545, 1348-7019
  • Peer Reviewed
• [Journal Article] Novel sterol glucosyltransferase in the animal tissue and cultured cells : Evidence that glucosylceramide as glucose donor (2011)
  • Author(s): 秋山央子、佐々木成江、小林進、平林義雄、室伏きみ子
  • Journal Title: Biochimica et Biophysica Acta-Molecular ana Cell Biology of Lipids Volume: 1,811 Issue: 5 Pages: 314-322
  • DOI: 10.1016/j.bbalip.2011.02.005
  • Peer Reviewed
• [Journal Article] A screening of a library of T7 phage-displayed peptide identifies E2F-4 as an etoposide-binding protein (2011)
  • Author(s): 鷹見美穂子、高草木洋一、、太田慶介、小林進、坂口謙吾、菅原二三男
  • Journal Title: Molecules Volume: 16 Issue: 5 Pages: 4278-4294
  • DOI: 10.3390/molecules16054278
  • Peer Reviewed
• [Journal Article] Efficient synthesis of 3-0-thia-cPA and preliminary analysis of its biological activity toward autotaxin (2011)
  • Author(s): 田中遼、加藤賢、鈴木孝洋、中崎敦夫、野崎絵美、後藤真理、室伏きみ子、小林進
  • Journal Title: Bioorganic & Medicinal Chemistry Letters Volume: 21 Issue: 14 Pages: 4180-4182
  • DOI: 10.1016/j.bmcl.2011.05.083
  • Peer Reviewed
• [Journal Article] Transformation of thiols to disulfides by epolactaene and its derivatives (2011)
  • Author(s): 倉持幸司、橘木崇、椿一典、水品義之、坂口謙吾、菅原二三男、池北雅彦、小林進
  • Journal Title: Bloorganic & Medicinal Chemistry Volume: 19 Issue: 14 Pages: 4162-4172
  • DOI: 10.1016/j.bmc.2011.06.015
  • Peer Reviewed
• [Journal Article] Determination of the absolute structure of (+)-akaterpin (2011)
  • Author(s): 細井勇人、河井伸之、萩原秀樹、鈴木孝洋、中崎敦夫、高尾賢一、梅澤一夫、小林進
  • Journal Title: Chem.Pharm.Bull Volume: 60 Pages: 137-143
  • NAID: 130001852337
  • Peer Reviewed
• [Journal Article] Total Synthesis of (+)-Nafuredin-γ Using a Highly Stereoselective Ti-medfated Aldol Reaction (2011)
  • Author(s): 小野寺裕太、鈴木孝洋、小林進
  • Journal Title: Organic Letters Volume: 13 Pages: 50-53
  • Peer Reviewed
• [Journal Article] Convergent Total Synthesis of (+)-TMC-151C Using Vinylogous Mukaiyama Aldol Reaction and Ring-Closing Metathesis (2011)
  • Author(s): 松井亮介、瀬戸健太郎、佐藤優奈、鈴木孝洋、中崎敦夫、小林進
  • Journal Title: Angew.Chemie, Int.Ed. Volume: 50 Pages: 680-683
  • Peer Reviewed
• [Journal Article] Stereoselective Vinylogous Mukaiyama Aldol Reaction of α-Haloenals (2011)
  • Author(s): 岩崎陽一、松井亮介、鈴木孝洋、中崎敦夫、小林進
  • Journal Title: Chem.Pharm.Bull. Volume: 59(印刷中)
  • Peer Reviewed
• [Journal Article] Unusual Selective E-Olefin Forming 8-Membered Ring Closing Metathesis (2010)
  • Author(s): R. Matsui, K. Seto, K. Fujita, T. Suzuki, A.Nakazaki, S. Kobayashi
  • Journal Title: Angewandte Chemie Int. Ed. Volume: 49 Issue: 52 Pages: 10068-10073
  • DOI: 10.1002/anie.201004746
  • Peer Reviewed
• [Journal Article] Concise Approach to Pupukeanane Skeleton: Synthetic Study of Chloropupukeananin (2010)
  • Author(s): T. Suzuki, S. Kobayashi
  • Journal Title: Organic Letters Volume: 12 Issue: 13 Pages: 2920-2923
  • DOI: 10.1021/ol100935w
  • Peer Reviewed
• [Journal Article] Second-Generation Total Synthesis of (-)-Diversifolin (2010)
  • Author(s): K. Tsuboi, T. Nakamura, T. Suzuki, A.Nakazaki, S. Kobayashi
  • Journal Title: Tetrahedron Letters Volume: 51 Issue: 14 Pages: 1876-1879
  • DOI: 10.1016/j.tetlet.2010.02.012
  • Peer Reviewed
• [Journal Article] Second-Generation Total Synthesis of (-)-Diversifolin (2010)
  • Author(s): 坪井和馬、中村友昭、鈴木孝洋、中崎敦夫、小林進
  • Journal Title: Tetrahedron Lettere Volume: 51 Pages: 1876-1879
  • Peer Reviewed
• [Journal Article] Unusual Selective E-Olefin Forming 8-Membered Ring Closing Metathesis (2010)
  • Author(s): 松井亮介、瀬戸健太郎、藤田和弘、鈴木孝洋、中崎敦夫、小林進
  • Journal Title: Angew.Chemie, Int.Ed. Volume: 49 Pages: 10068-10073
  • Peer Reviewed
• [Presentation] 逆電子要請型Diels-Alder反応による多環性骨格の構築 (2012)
  • Author(s): 小林 進
  • Organizer: 平成24年度後期有機合成化学講習会
  • Place of Presentation: 薬学会館、東京
  • Year and Date: 2012-12-11
• [Presentation] ビニロガス向山アルドール反応の開発と天然物合成への応用 (2012)
  • Author(s): 小林 進
  • Organizer: 東京農工大学有機化学セミナー
  • Place of Presentation: 東京農工大学工学部、東京
  • Year and Date: 2012-12-10
• [Presentation] Incensol Acetateの合成研究 (2012)
  • Author(s): 木村真菜、正木すなみ、朝比奈裕宗、鈴木孝洋、小林 進
  • Organizer: 第64回有機合成化学協会関東支部シンポジウム
  • Place of Presentation: 長岡科学技術大学、新潟
  • Year and Date: 2012-12-01
• [Presentation] ビニロガス向山アルドール反応を用いたMethynolideの効率的な合成研究 (2012)
  • Author(s): 藤村正貴、松井亮介、鈴木孝洋、小林 進
  • Organizer: 第64回有機合成化学協会関東支部シンポジウム
  • Place of Presentation: 長岡科学技術大学、新潟
  • Year and Date: 2012-12-01
• [Presentation] 古くても伝えたい二つのこと:20代と30代の時の研究から (2012)
  • Author(s): 小林 進
  • Organizer: 第64回有機合成化学協会関東支部シンポジウム
  • Place of Presentation: 長岡科学技術大学、新潟
  • Year and Date: 2012-12-01
• [Presentation] 新しい方法論の開発に基づく生物活性天然物の合成研究 (2012)
  • Author(s): 小林 進
  • Organizer: 第30回メディシナルケミストリーシンポジウム
  • Place of Presentation: タワーホール船堀、東京
  • Year and Date: 2012-11-29
• [Presentation] 天然物の全合成におけるモデル化合物設定の難しさ (2012)
  • Author(s): 小林 進
  • Organizer: 早稲田大学理工学術院講演会
  • Place of Presentation: 早稲田大学、東京
  • Year and Date: 2012-10-19
• [Presentation] Synthetic Organic Chemistry as a Fundamental and a Tool in Bioscience (2012)
  • Author(s): S. Kobayashi
  • Organizer: 2012 Bilateral Symposium of Tokyo University of Science and Sichuan University
  • Place of Presentation: 成都・四川大学、中国
  • Year and Date: 2012-08-11
• [Presentation] 新しい方法論の開発と天然物合成への応用 (2012)
  • Author(s): 小林 進
  • Organizer: 理研シンポジウム 第7回有機合成化学のフロンティア
  • Place of Presentation: 理化学研究所、埼玉
  • Year and Date: 2012-07-06
• [Presentation] Development of New Methodology and Application to Natural Product Synthesis (2012)
  • Author(s): S. Kobayashi
  • Organizer: ESPCI Organic Chemistry Seminar
  • Place of Presentation: Ecole Superieure de Physique de Chimie Industrielles (ESPCI), Paris, France
  • Year and Date: 2012-06-22
• [Presentation] Development of New Methodology and Application to Natural Product Synthesis (2012)
  • Author(s): S. Kobayashi
  • Organizer: Mini-Symposium at Leibniz University Hannover
  • Place of Presentation: Leibniz University Hannover, Hannover, German
  • Year and Date: 2012-06-19
• [Presentation] アトロプルプランの合成研究 (2012)
  • Author(s): 鈴木孝洋、佐々木綾、江頭直樹、小林 進
  • Organizer: 日本化学会第92春季年会
  • Place of Presentation: 慶応義塾大学・横浜
  • Year and Date: 2012-03-26
• [Presentation] Synthetic study on Pyrrocidines (2012)
  • Author(s): 大石健太郎、田中遼、高梨憲幸、長野智彦、鈴木孝洋、小林進
  • Organizer: 10th Symposium on Chemical Approaches to Chirality
  • Place of Presentation: 東京理科大学・東京
  • Year and Date: 2012-02-24
• [Presentation] 生物活性天然物の全合成と新しい方法論の開発 (2012)
  • Author(s): 小林進
  • Organizer: 有機合成のニュートレンド2012
  • Place of Presentation: 大阪市・エルおおさか
  • Year and Date: 2012-02-02
• [Presentation] 生物活性天然物の全合成-目的と意義- (2012)
  • Author(s): 小林進
  • Organizer: 神戸薬科大学特別講演会
  • Place of Presentation: 神戸市・神戸薬科大学
  • Year and Date: 2012-02-01
• [Presentation] 天然物合成における骨格構築の醍醐味 (2012)
  • Author(s): 小林 進
  • Organizer: 名古屋大学工学研究科特別講演会
  • Place of Presentation: 名古屋大学
  • Year and Date: 2012-01-12
• [Presentation] 新しい方法論の開発と天然物合成への応用 (2012)
  • Author(s): 小林 進
  • Organizer: 理研シンポジウム 第７回有機合成化学のフロンティア
  • Place of Presentation: 理化学研究所、埼玉
  • Invited
• [Presentation] 古くても伝えたい二つのこと：20代と30.代の時の研究から (2012)
  • Author(s): 小林 進
  • Organizer: 第64回有機合成化学協会関東支部シンポジウム
  • Place of Presentation: 長岡科学技術大学、新潟
  • Invited
• [Presentation] Methynolideの合成研究 (2012)
  • Author(s): 藤村正貴、松井亮介、鈴木孝洋、小林 進
  • Organizer: 第63回有機合成化学協会関東支部シンポジウム
  • Place of Presentation: 東京理科大学野田キャンパス、千葉
• [Presentation] Synthetic study of Atropurpuran (2011)
  • Author(s): 鈴木孝洋、佐々木綾、江頭直樹、小林進
  • Organizer: 8tn AFMC International Medicinal Chemistry Symposium (AIMECS11)
  • Place of Presentation: 京王プラザホテル・東京
  • Year and Date: 2011-12-01
• [Presentation] Methynolideの合成研究 (2011)
  • Author(s): 藤村正貴、松井亮介、鈴木孝洋、小林進
  • Organizer: 第62回有機合成化学協会関東支部シンポジウム
  • Place of Presentation: 新潟大学工学部,新潟
  • Year and Date: 2011-11-26
• [Presentation] 環状リン脂質の硫黄誘導体(3-0-thia-cPA)の効率的合成およびオートタキシン阻害活性 (2011)
  • Author(s): 田中遼、加藤賢、鈴木孝洋、中崎敦夫、野崎絵美、後藤真里、室伏きみ子、小林進
  • Organizer: 第62回有機合成化学協会関東支部シンポジウム
  • Place of Presentation: 新潟大学工学部,新潟
  • Year and Date: 2011-11-26
• [Presentation] Chloropupukeananinの合成研究 (2011)
  • Author(s): 鈴木孝洋、岩切佳那子、宮嶋ゆりあ、鈴木要、石見遼、小清水正樹、小林進
  • Organizer: 第100回有機合成シンポジウム
  • Place of Presentation: 早稲田大学,東京
  • Year and Date: 2011-11-11
• [Presentation] Chloropupukeananinの合成研究 (2011)
  • Author(s): 鈴木孝洋、岩切佳那子、宮嶋ゆりあ、鈴木要、石見遼、小清水正樹、小林 進
  • Organizer: 第100回有機合成シンポジウム
  • Place of Presentation: 早稲田大学、東京
  • Year and Date: 2011-11-10
• [Presentation] Chloropupukeananinの合成研究 (2011)
  • Author(s): 鈴木孝洋, 宮嶋ゆりあ, 鈴木要, 小清水正樹, 小林進
  • Organizer: 第37回反応と合成の進歩シンポジウム
  • Place of Presentation: あわぎんホール,徳島
  • Year and Date: 2011-11-08
• [Presentation] 28-Deacetylbelamcandalの合成研究 (2011)
  • Author(s): 高梨憲幸, 田村圭司, 邊見和輝, 鈴木孝洋, 中崎敦夫, 小林進
  • Organizer: 第37回反応と合成の進歩シンポジウム
  • Place of Presentation: あわぎんホール,徳島
  • Year and Date: 2011-11-08
• [Presentation] スコラリシンAの合成研究 (2011)
  • Author(s): 清水恭平、鈴木孝洋、小林進
  • Organizer: 第41回複素環化学討論会
  • Place of Presentation: 熊本、熊本市民会館
  • Year and Date: 2011-10-22
• [Presentation] 抗菌活性物質ピロシジン類の合成研究 (2011)
  • Author(s): 大石健太郎、田中遼、高梨憲幸、長野智彦、鈴木孝洋、小林進
  • Organizer: 第55回日本薬学会関東支部大会
  • Place of Presentation: 東邦大学習志野キャンパス
  • Year and Date: 2011-10-08
• [Presentation] リコプラジンHの合成研究 (2011)
  • Author(s): 金津一樹、鈴木孝洋、小林進
  • Organizer: 第55回日本薬学会関東支部大会
  • Place of Presentation: 東邦大学習志野キャンパス
  • Year and Date: 2011-10-08
• [Presentation] エポラクタエン及び誘導体の特異なチオリシス反応 (2011)
  • Author(s): 倉持幸司、小林進、椿一典
  • Organizer: 2011年度日本農芸化学会関西・中部支部合同大会
  • Place of Presentation: 京都大学・京都
  • Year and Date: 2011-10-01
• [Presentation] C-N軸性キラリティを利用した3,3-二置換オキシインドールの新規立体制御法 (2011)
  • Author(s): 中崎敦夫, 森綾子, 小林進, 西川俊夫
  • Organizer: 2011年度日本農芸化学会関西・中部支部合同大会
  • Place of Presentation: 京都大学・京都
  • Year and Date: 2011-10-01
• [Presentation] Synthetic study on Two Natural Products, Chloropupukeananine and Atropurpuran, Utilizing Reverse Electron Demand Diels-Alder Reaction (2011)
  • Author(s): 小林進
  • Organizer: Special Seminar of Organic Chemistry
  • Place of Presentation: University of Strasbourg (France)
  • Year and Date: 2011-09-19
• [Presentation] Synthetic Study on Fomitellic Acids (2011)
  • Author(s): 山岡誠、深津裕一、阿部祐樹、鈴木孝洋、中崎敦夫、小林進
  • Organizer: 22nd French-Japanese Symposium of Medicinal and Fine Chemistry
  • Place of Presentation: Rouen (France)
  • Year and Date: 2011-09-12
• [Presentation] Development of Stereoselective Vinylogous Mukaiyama Aldol Keaction and Application to Natural Product Synthesis (2011)
  • Author(s): 小林進
  • Organizer: 1st Scottish-Japanese Symposium in Organic Chemistry
  • Place of Presentation: Glasgow (Scotland)
  • Year and Date: 2011-09-09
• [Presentation] Development of Stereoselective Vinylogous Mukaiyama Aldol Reaction and Application to Natural Product Synthesis (2011)
  • Author(s): S. Kobayashi
  • Organizer: 1st Scottish-Japanese Symposium in Organic Chemistry
  • Place of Presentation: Glasgow,Scotland
  • Year and Date: 2011-09-08
• [Presentation] Design and Synthesis of Molecular Probe for Identifying Intracellular Protein Target (2011)
  • Author(s): 戸井崎絢、鈴木愛子、中崎敦夫、鈴木孝洋、高草木洋一、菅原二三男、坂口謙吾、小林進
  • Organizer: International Symposium on Technologies against Cancer (ISTC2011)
  • Place of Presentation: タワーホール船堀,東京
  • Year and Date: 2011-09-02
• [Presentation] Synthetic Study of Nafuredin-gamma and Incensol Acetate Based on Ti-Mediated Aldol Reaction of Lactyl-bearing Chiral Oxazolidin-2-one (2011)
  • Author(s): 小野寺祐太、正木すなみ、鈴木孝洋、小林進
  • Organizer: 23rd International Congress of Heterocyclic Chemistry
  • Place of Presentation: Glasgow, UK
  • Year and Date: 2011-08-02
• [Presentation] Myxalamide Aの効率的合成研究 (2011)
  • Author(s): 藤田和弘, 松井亮介, 鈴木孝洋, 小林進
  • Organizer: 第46回天然物化学談話会
  • Place of Presentation: 熱川ハイツ、静岡
  • Year and Date: 2011-07-07
• [Presentation] 抗菌活性物質ピロシジン類の合成研究 (2011)
  • Author(s): 田中遼, 大右健太郎, 高梨憲幸, 鈴木孝洋, 小林進
  • Organizer: 第46回天然物化学談話会
  • Place of Presentation: 熱川ハイツ、静岡
  • Year and Date: 2011-07-07
• [Presentation] 28-deacetylbelamcandalの合成研究 (2011)
  • Author(s): 高梨憲幸, 田村圭司, 邊見和輝, 鈴木孝洋, 中崎敦夫、小林進
  • Organizer: 第46回天然物化学談話会
  • Place of Presentation: 熱川ハイツ、静岡
  • Year and Date: 2011-07-07
• [Presentation] Histrionicotoxin 235Aの合成研究 (2011)
  • Author(s): 加藤賢, 鈴木孝洋, 中崎敦夫, 小林進
  • Organizer: 第46回天然物化学談話会
  • Place of Presentation: 熱川ハイツ、静岡
  • Year and Date: 2011-07-07
• [Presentation] 天然物の全合成⇔方法論の開発 (2011)
  • Author(s): 小林進
  • Organizer: 第46回天然物化学談話会
  • Place of Presentation: 熱川ハイツ、静岡
  • Year and Date: 2011-07-07
• [Presentation] 抗寄生虫活性物質Nafuredin-γの効率的全合成 (2011)
  • Author(s): 小野寺祐太, 鈴木孝洋, 小林進
  • Organizer: 第46回天然物化学談話会
  • Place of Presentation: 熱川ハイツ、静岡
  • Year and Date: 2011-07-07
• [Presentation] Total Synthesis and Structure Determination of PI-PLC Inhibitor Akaterpin (2011)
  • Author(s): 細井勇人、河井伸之、鈴木孝洋、中崎敦夫、小林進
  • Organizer: 12th Tetrahedron Symposium
  • Place of Presentation: Sitges (Spain)
  • Year and Date: 2011-06-22
• [Presentation] Natural Product Synthesis by Vinylogous Mukaiyama Aldol Reaction (2011)
  • Author(s): 小林進
  • Organizer: Organic Chemistry Seminar of Lund University
  • Place of Presentation: Lund University (Sweden)
  • Year and Date: 2011-06-19
• [Presentation] gous Mukaiyama Aldol Reaction and its Application to Natural Product Synth (2011)
  • Author(s): 小林進
  • Organizer: Danish ChemicalSociety Division of Organic Chemistry Lecture
  • Place of Presentation: University of Copenhagen (Denmark)
  • Year and Date: 2011-06-16
• [Presentation] 抗真菌活性ポリエンMyxalamide Aの効率的合成研究 (2011)
  • Author(s): 藤田和弘、松井亮介、鈴木孝洋、小林進
  • Organizer: 第61回有機合成化学協会関東支部シンポジウム
  • Place of Presentation: 千葉大学
  • Year and Date: 2011-05-22
• [Presentation] 特異な四環性骨格を有するMangicol Aの合成研究 (2011)
  • Author(s): 平野瑞李、山下大輔、鈴木孝洋、小林進、L.Miesch、M.Miesch
  • Organizer: 第61回有機合成化学協会関東支部シンポジウム
  • Place of Presentation: 千葉大学
  • Year and Date: 2011-05-22
• [Presentation] Chloropupukeananinの合成研究 (2011)
  • Author(s): 鈴木孝洋、岩切佳那子、鈴木要, 宮嶋ゆりあ、石見遼、小林進
  • Organizer: 第61回有機合成化学協会関東支部シンポジウム
  • Place of Presentation: 千葉大学
  • Year and Date: 2011-05-22
• [Presentation] 抗菌活性物質ピロシジン類の合成研究 (2011)
  • Author(s): 田中遼、大石健太郎、高梨憲幸、鈴木孝洋、小林進
  • Organizer: 第61回有機合成化学協会関東支部シンポジウム
  • Place of Presentation: 千葉大学
  • Year and Date: 2011-05-22
• [Presentation] ケイ素テザーを介した新規E選択的8員環形成閉環メタセシスの開発 (2010)
  • Author(s): 藤田和弘、松井亮介、瀬戸健太郎、中崎敦夫、鈴木孝洋、小林進
  • Organizer: 第60回有機合成化学協会関東支部シンポジウム
  • Place of Presentation: 新潟薬科大学(新潟県)
  • Year and Date: 2010-12-04
• [Presentation] Fomitellic acid類の合成研究 (2010)
  • Author(s): 深津裕一、山岡誠、金津一樹、中崎敦夫、鈴木孝洋、小林進
  • Organizer: 第60回有機合成化学協会関東支部シンポジウム
  • Place of Presentation: 新潟薬科大学(新潟県)
  • Year and Date: 2010-12-04
• [Presentation] ビニロガス向山アルドール反応と閉環メタセシスを鍵反応とした抗腫瘍性物質(+)-TMC-151Cの全合成 (2010)
  • Author(s): 松井亮介、瀬戸健太郎、佐藤優奈、藤田和弘、鈴木孝洋、中崎敦夫、小林進
  • Organizer: 第52回天然有機化合物討論会
  • Place of Presentation: グランシップ(静岡県)
  • Year and Date: 2010-09-29
• [Presentation] Nafuredin-γの合成研究-不斉三級アルコールを含むanti-1,2-diolの構築- (2010)
  • Author(s): 小野寺祐太、鈴木孝洋、小林進
  • Organizer: 第59回有機合成化学協会関東支部シンポジウム
  • Place of Presentation: 東京農工大学(東京都)
  • Year and Date: 2010-05-22
• [Book] (2012)
  • Author(s): 小林 進,三巻祥浩
  • Total Pages: 137
  • Publisher: 培風館
• [Book] 基礎有機化学 (2012)
  • Author(s): 小林進・三巻祥浩
  • Total Pages: 137
  • Publisher: 培風館
• [Remarks] 東京理科大学薬学部小林研究室
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• [Remarks] 東京理科大学薬学部小林研究室ホームページ
  • URL: http://www.rs.noda.tus.ac.jp/kobalab/index.html
• [Remarks]
  • URL: http://www.rs.noda.tus.ac.jp/kobalab/index.html
• [Remarks]
  • URL: http://www.rs.noda.tus.ac.jp/kobalab/index.html