Structural insight into the signal transduction mechanism of TRAF6related proteins
| Project/Area Number |
22390008
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Kumamoto University |
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Principal Investigator |
YAMAGATA Yuriko 熊本大学, 大学院・生命科学研究部, 教授 (40183678)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2012: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2010: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Keywords | タンパク質 / シグナル伝達 / 構造生物学 / タンパク質の結晶化 / 蛋白質 |
|---|
| Research Abstract |
Tumor necrosis factor (TNF) is a well-known inflammatory cytokine that is implicatedin several autoimmune diseases such as rheumatoid arthritis. Here we show the firstcrystal structure of the TNF-TNFR2 complex. Structural differences between TNFR1 andTNFR2 are analyzed and discussed. This data will be key to the future development oflow-toxic TNFR1 selective therapies. In addition, we also reveal the formation of a TNFR2supra-complex on the cell surface. Aggregation of these receptors may contribute to thecurrently unidentified mechanism of TNFR superfamily signal initiation.Tumor necrosis factor receptor-associated factor 6 (TRAF6) transduces signals frommembers of the Toll/interleukin-1 (IL-1) receptor and TNFR families. Here we show thatthe first crystal structure of the TRAF6 binding protein. The TRAF6 binding protein formsa dimer.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Structural Insights into Differences inDrug-binding Selectivity between Two Forms ofHuman1-Acid Glycoprotein Genetic Variants,the A and F1*S Forms2011
Author(s)
K Nishi, T Ono, TNakamura, N Fukunaga, M Izumi, H Watanabe,A Suenaga, T Maruyama, Y Yamagata, S Curryand M Otagiri, J
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Journal Title
Biol. Chem
Volume: 286
Pages: 14427-14434
Related Report
Peer Reviewed
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[Journal Article] The crystal structure of the green teapolyphenol(-)-epigallocatechingallate (EGCG)-transthyretin complex reveals a novel bindingsite distinct from the thyroxine binding site2010
Author(s)
MMiyata, T Sato, M Kugimiya, M Sho, TNakamura, S Ikemizu, M Chirifu, M Mizuguchi, YNabeshima, Y Suwa, H Morioka, T Arimori, M ASuico, T Shuto, Y Sako, M Momohara, T Koga, SMorino-Koga, Y Yamagata and H Kai
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Journal Title
Biochemistry
Volume: 49
Pages: 6104-6114
Related Report
Peer Reviewed
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[Presentation] Crystal Structure of lnterleukin-232011
Author(s)
TakumiShirouzono, Mami Chirifu, Chiharu Nakamura,Teruya Nakamura, Yuriko Yamagata, ShinjiIkemizu
Organizer
17thInternational Conference ofBiophysics
Place of Presentation
Beijing, China
Year and Date
2011-11-03
Related Report
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[Presentation] Solution of the Structure of the TNF-TNFR2Complex2011
Author(s)
Yohei Mukai, Teruya Nakamura, MaiYoshikawa, Yasuo Yoshioka, Shin-ichi Tsunoda,Shinsaku Nakagawa, Yuriko Yamagata, andYasuo Tsutsumi
Organizer
XXII Congress of theInternational Union of Crystallography
Place of Presentation
Madrid, Spain
Year and Date
2011-08-24
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