Drug development on protein misfolding diseases

• Project/Area Number: 22390015
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Kumamoto University
• Principal Investigator: KAI Hirofumi 熊本大学, 大学院・生命科学研究部, 教授 (30194658)
• Co-Investigator(Kenkyū-buntansha): SHUTO Tsuyoshi 熊本大学, 大学院・生命科学研究部, 准教授 (80333524) ; MARY ANN Suico 熊本大学, 大学院・生命科学研究部, 助教 (20363525)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000); Fiscal Year 2012: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2011: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2010: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
• Keywords: 薬理学 / タンパク質 / 遺伝病 / cystic fibrosis / FAP / CFTR / transthyretin / amyloidosis / phosphatidic acid / mucin / 小胞体 / アミロイド / ENaC

Research Abstract

Drug development for cystic fibrosis (CF) and familial amyloidpolyneuropathy (FAP) is still in progress. We established the CF-like model mouse stablyproducing sputum to evaluate various kinds of medicine, and we found a novel mechanismfor the endoplasmic reticulum-associated degradation of transthyretin variants inmammalian cells

Research Products

• [Journal Article] STT3B-dependent posttranslationalN-glycosylation as a novel surveillancesystem for secretory protein (2012)
  • Author(s): Sato T, Sako Y, Sho M, Momohara M, SuicoMA, Shuto T, Nishitoh H, Okiyoneda T,Kokame K, Kaneko M, Taura M, Miyata M,Chosa K, Koga T, Koga SM, Wada I, Kai H
  • Journal Title: Mol. Cell Volume: 47 Pages: 99-110
  • Peer Reviewed
• [Journal Article] Rb/E2F1 Regulatesthe Innate Immune Receptor Toll-LikeReceptor 3 in Epithelial Cells (2012)
  • Author(s): Taura M, Suico MA, Koyama K, Komatsu K,Miyakita R, Matsumoto C, Kudo E, Kariya R,Goto H, Kitajima S, Takahashi C, Shuto T,Nakao M, Okada S, Kai H
  • Journal Title: Mol. Cell.Biol Volume: 32 Pages: 1581-90
  • Peer Reviewed
• [Journal Article] SynergismBetween Interleukin (IL)-17 and Toll-likeReceptor 2 and 4 Signals to Induce IL-8Expression in Cystic Fibrosis AirwayEpithelial Cells (2012)
  • Author(s): Mizunoe S, Shuto T, Suzuki S, MatsumotoC, Watanabe K, Ueno-Shuto K, Suico MA,Onuki K, Gruenert DC, Kai H
  • Journal Title: J. Pharmacol. Sci Volume: 118 Pages: 512-520
  • Peer Reviewed
• [Journal Article] STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein. (2012)
  • Author(s): Sato T., et.al.
  • Journal Title: Molecular Cell Volume: 47(1) Issue: 1 Pages: 99-110
  • DOI: 10.1016/j.molcel.2012.04.015
  • Peer Reviewed
• [Journal Article] Synergism Between Interleukin (IL)-17 and Toll-like Receptor 2 and 4 Signals to Induce IL-8 Expression in Cystic Fibrosis Airway Epithelial Cells. (2012)
  • Author(s): Shota Mizunoe
  • Journal Title: Journal of Pharmacological Sciences Volume: 118 Pages: 512-520
  • Peer Reviewed
• [Journal Article] Rb/E2F1 regulates the innate immune receptor Toll-like receptor 3 in epithelial cells (2012)
  • Author(s): Taura M., et.al.
  • Journal Title: Molecular and Cellular Biology Volume: 32(8) Issue: 8 Pages: 1581-1590
  • DOI: 10.1128/mcb.06454-11
  • Peer Reviewed
• [Journal Article] Mild electrical stimulation and heat shock ameliorates progressive proteinuria and renal inflammation in mouse model of Alport syndrome. (2012)
  • Author(s): Tomoaki Koga
  • Journal Title: PLoS One Volume: 7 Issue: 8 Pages: 43852-43852
  • DOI: 10.1371/journal.pone.0043852
  • Peer Reviewed
• [Journal Article] Diethyldithiocarbamate induces apoptosis in HHV-8-infected primary effusion lymphoma cells via inhibition of the NF-kB pathway (2012)
  • Author(s): Matsuno T, et al
  • Journal Title: International Journal of Oncology Volume: 40 Pages: 1071-1078
  • DOI: 10.3892/ijo.2011.1313
  • Peer Reviewed
• [Journal Article] Phosphodiesterase 4B Mediates Extracellular Signal-regulated Kinase-dependent Up-regulation of Mucin MUC5AC Protein by Streptococcus pneumoniae by Inhibiting cAMP-protein Kinase A-dependent MKP-1 Phosphatase Pathway. (2012)
  • Author(s): Lee J
  • Journal Title: J Biol Chem. Volume: 287 Issue: 27 Pages: 22799-22811
  • DOI: 10.1074/jbc.m111.337378
  • Peer Reviewed
• [Journal Article] Insulin receptor activation through its accumulation in lipid rafts by mild electrical stress (2012)
  • Author(s): Morino-Koga S
  • Journal Title: J Cell Physiol. Volume: 228 Issue: 2 Pages: 439-446
  • DOI: 10.1002/jcp.24149
  • Peer Reviewed
• [Journal Article] Diethyldithiocarbamate induces apoptosis in HHV-8-infected primary effusion lymphoma cells via inhibition of the NF-κB pathway (2012)
  • Author(s): Matsuno T, Kariya R, Yano S, Morino-Koga S, Taura M, Suico MA, Shimauchi y Matsuyama S, Okamoto Y, Shuto T, Kai H, Okada S
  • Journal Title: Int J Oncol Volume: 40(4) Pages: 1071-1078
  • Peer Reviewed
• [Journal Article] Synergism Between Interleukin (IL)-17 and Toll-like Receptor 2 and 4 Signals to Induce IL-8 Expression in Cystic Fibrosis Airway Epithelial Cells (2012)
  • Author(s): Mizunoe S, Shuto T, Suzuki S, Matsumoto C, Watanabe K, Ueno-Shuto K, Suico MA, Onuki K, Gruenert DC, Kai H
  • Journal Title: J Pharmacol Sci Volume: (印刷中)
  • NAID: 10030572169
  • Peer Reviewed
• [Journal Article] Hyperthermia With Mild Electrical Stimulation Protects Pancreatic β-Cells From Cell Stresses and Apoptosis (2012)
  • Author(s): Kondo T, Sasaki K, Matsuyama R, Morino-Koga S, Adachi H, Suico MA, Kawashima J, Motoshima H, Furukawa N, Kai H, Araki E
  • Journal Title: Diabetes Volume: 61(4) Pages: 838-847
  • NAID: 120005368280
  • Peer Reviewed
• [Journal Article] Rb/E2F1 Regulates the Innate Immune Receptor Toll-Like Receptor 3 in Epithelial Cells (2012)
  • Author(s): Taura M, Suico MA, Koyama K, Komatsu K, Miyakita R, Matsumoto C, Kudo E, Kariya R, Goto H, Kitajima S, Takahashi C, Shuto T, Nakao M, Okada s, Kai H
  • Journal Title: Mol Cell Biol Volume: 32(8) Pages: 1581-1590
  • Peer Reviewed
• [Journal Article] CFTR-deficiency renders mice highlysusceptible to cutaneous symptoms duringmite infestation (2011)
  • Author(s): Hashimoto Y, Shuto T, Mizunoe S, TomitaA, Koga T, Sato T, Takeya M, Suico MA,Niibori A, Sugahara T, Shimasaki S,Sugiyama T, Scholte B, Kai H
  • Journal Title: Lab Invest Volume: 91(4) Pages: 509-18
  • Peer Reviewed
• [Journal Article] MEF/ELF4 transactivation by E2F1 isinhibited by p53 (2011)
  • Author(s): Taura M, Suico MA, Fukuda R, Koga T,Shuto T, Sato T, Morino-Koga S, Okada S, KaiH
  • Journal Title: Nucleic Acids Res Volume: 39(1) Pages: 76-88
  • Peer Reviewed
• [Journal Article] Posttranslational negativeregulation of glycosylated andnon-glycosylated BCRP expression byDerlin-1 (2011)
  • Author(s): Sugiyama T, Shuto T, Suzuki S, Sato T,Koga T, Suico MA, Kusuhara H, Sugiyama Y,Cyr DM, Kai H
  • Journal Title: Biochem Biophys Res Commun Volume: 404(3) Pages: 853-8
  • Peer Reviewed
• [Journal Article] Lucidenic acids-rich extract from antlered form of Ganoderma lucidum enhances TNF α induction in THP-1 monocytic cells possibly via its modulation of MAP kinases p38 and JNK (2011)
  • Author(s): Watanabe K, Shuto T, Sato M, Onuki K, Mizunoe S, Suzuki S, Sato T, Koga T, Suico MA, Kai H, Ikeda T
  • Journal Title: Biochem Biophys Res Commun Volume: 408(1) Pages: 18-24
  • Peer Reviewed
• [Journal Article] CFTR-deficiency renders mice highly susceptible to cutaneous symptoms during mite infestation (2011)
  • Author(s): Hashimoto Y, Shuto T, Mizunoe S, Tomita A, Koga T, Sato T, Takeya M, Suico MA, Niibori A, Sugahara T, Shimasaki S, Sugiyama T, Scholte B, Kai H
  • Journal Title: Lab Invest Volume: 91(4) Pages: 509-518
  • Peer Reviewed
• [Journal Article] Posttranslational negative regulation of glycosylated and non-glycosylated BCRP expression by Derlin-1 (2011)
  • Author(s): Sugiyama T, Shuto T, Suzuki S, Sato T, Koga T, Suico MA, Kusuhara H, Sugiyama Y, Cyr DM, Kai H
  • Journal Title: Biochem Biophys Res Commun Volume: 404(3) Pages: 853-858
  • Peer Reviewed
• [Journal Article] Posttranslational negative regulation of glycosylated and non-glycosylated BCRP expression by Derlin-1. (2011)
  • Author(s): Sugiyama T, et al.
  • Journal Title: Biochem Biophys Res Commun. Volume: 404(3) Pages: 853-858
  • Peer Reviewed
• [Journal Article] Glucose Uptake in Rat Skeletal Muscle L6 Cells Is Increased by Low-Intensity Electrical Current Through the Activation of the Phosphatidylinositol-3-OH kinase (PI-3K)/Akt Pathway. (2011)
  • Author(s): Yano S, et al.
  • Journal Title: J Pharmacol Sci. Volume: 115(1) Pages: 94-98
  • Peer Reviewed
• [Journal Article] Role of theglutamic acid 54 residue in transthyretin stability and thyroxine binding (2010)
  • Author(s): Miyata M, Sato T, Mizuguchi M, NakamuraT, Ikemizu S, Nabeshima Y, Susuki S, SuwaY, Morioka H, Ando Y, Suico MA, Shuto T,Koga T, Yamagata Y, and Kai H
  • Journal Title: Biochemistry Volume: 49 Pages: 114-23
  • Peer Reviewed
• [Journal Article] Crystal structure of green teapolyphenol(-)-epigallocatechin gallate(EGCG)-transthyretin complex revealsnovel binding site distinct fromthyroxine binding site (2010)
  • Author(s): Miyata M, Sato T, Kugimiya M, Sho M,Nakamura T, Ikemizu S, Chirifu M,Mizuguchi M, Nabeshima Y, Suwa Y, MoriokaH, Arimori T, Suico MA, Shuto T, Sako Y,Momohara M, Koga T, Morino-Koga S, YamagataY, Kai H
  • Journal Title: Biochemistry Volume: 49 Pages: 6104-14
  • Peer Reviewed
• [Journal Article] TLR3 induction by anticancer drugspotentiates poly I:C-induced tumor cellapoptosis (2010)
  • Author(s): Taura M, Fukuda R, Suico MA, Eguma A,Koga T, Shuto T, Sato T, Morino-Koga S, KaiH
  • Journal Title: Cancer Sci Volume: 101(7) Pages: 1610-1
  • Peer Reviewed
• [Journal Article] Curcumindecreases toll-like receptor-2 geneexpression and function in human monocytesand neutrophils (2010)
  • Author(s): Shuto T, Ono T, Ohira Y, Shimasaki S,Mizunoe S, Watanabe K, Suico MA, Koga T,Sato T, Morino S, Sato K, Kai H
  • Journal Title: Biochem Biophys ResCommun Volume: 398(4) Pages: 647-52
  • Peer Reviewed
• [Journal Article] Endoplasmicreticulum stress increases the expressionand function of toll-like receptor-2 inepithelial cells (2010)
  • Author(s): Shimasaki S, Koga T, Shuto T, Suico MA,Sato T, Watanabe K, Morino-Koga S, TauraM, Okada S, Mori K and Kai H
  • Journal Title: Biochem Biophys ResCommun Volume: 402(2) Pages: 235-40
  • Peer Reviewed
• [Journal Article] CFTR-deficiency renders mice highly susceptible to cutaneous symptoms during mite infestation. (2010)
  • Author(s): Hashimoto Y, et al.
  • Journal Title: Lab Invest Volume: 91(4) Pages: 509-518
  • Peer Reviewed
• [Journal Article] Endoplasmic reticulum stress increases the expression and function of toll-like receptor-2 in epithelial cells. (2010)
  • Author(s): Shimasaki S, et al.
  • Journal Title: Biochem Biophys Res Common. Volume: 402(2) Pages: 235-240
  • Peer Reviewed
• [Journal Article] MEF/ELF4 transactivation by E2F1 is inhibited by p53. (2010)
  • Author(s): Taura M, et al.
  • Journal Title: Nucleic Acids Res. Volume: 39(1) Pages: 76-88
  • Peer Reviewed
• [Journal Article] Curcumin decreases toll-like receptor-2 gene expression and function in human monocytes and neutrophils. (2010)
  • Author(s): Shuto T, et al.
  • Journal Title: Biochem Biophys Res Commun Volume: 398(4) Pages: 647-652
  • Peer Reviewed
• [Journal Article] Crystal structure of green tea polyphenol(-)-epigallocatechin gallate (EGCG)-transthyretin complex reveals novel binding site distinct fromthyroxine binding site. (2010)
  • Author(s): Miyata M, et al.
  • Journal Title: Biochemistry. Volume: 49(29) Pages: 6104-6114
  • Peer Reviewed
• [Journal Article] TLR3 induction by anticancer drugs potentiates poly I : C-induced tumor cell apoptosis. (2010)
  • Author(s): Taura M, et al.
  • Journal Title: Cancer Sci. Volume: 101(7) Pages: 1610-1617
  • Peer Reviewed
• [Journal Article] Role of the glutamic acid 54 residue in transthyretin stability andthyroxine binding. (2010)
  • Author(s): Miyata M, et al.
  • Journal Title: Biochemistry. Volume: 49(1) Pages: 114-123
  • Peer Reviewed
• [Journal Article] 温熱電流同時印加療法 (2010)
  • Author(s): 近藤龍也, 他
  • Journal Title: BIO Clinica. Volume: 25(2) Pages: 78-83
  • Peer Reviewed
• [Presentation] 翻訳後 N型糖鎖修飾を介した小胞体品質管理機構による家族性アミロイドーシスの発症性制御機 構 の 解 明 (2013)
  • Author(s): 佐藤 卓史, 庄 美里, スイコ メリーアン, 首藤 剛, 甲斐 広文
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: パシフィコ横浜(横浜)
• [Presentation] 慢性腎疾患 Alport syndrome モデルマウスを用いた癌抑制遺伝子 p53 の腎保護的機能 の 解 明 (2013)
  • Author(s): 福田 亮介, 小山 皓介, 古賀 友紹,甲斐 友佳理, スイコ メリーアン, 大町 紘平, 本村 敬士, 首藤 剛, 甲斐広文
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡国際会議場(福岡)
• [Presentation] 異常な構造を持つ分泌タンパク質の新たな小胞体品質管理機構 (2013)
  • Author(s): 庄 美里, 佐藤 卓史, 帖佐 圭佑,山川 瑠斐子, スイコ メリーアン, 首藤剛, 甲斐 広文
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡国際会議場(福岡)
• [Presentation] 翻訳後N型糖鎖修飾を介した小胞体品質管理機構による家族性アミロイドーシスの発症性制御機構の解明 (2013)
  • Author(s): 佐藤 卓史
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: パシフィコ横浜（神奈川県）
• [Presentation] 慢性腎疾患 Alport syndrome モデルマウスを用いた癌抑制遺伝子p53の腎保護的機能の解明 (2013)
  • Author(s): 福田 亮介
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡国際会議場（福岡県）
• [Presentation] 異常な構造を持つ分泌タンパク質の新たな小胞体品質管理機構 (2013)
  • Author(s): 庄 美里
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡国際会議場（福岡県）
• [Presentation] 慢性腎疾患 Alport syndrome モデルマウスを用いた癌抑制遺伝子 p53 の腎保護的機能の解明 (2012)
  • Author(s): 福田 亮介, 小山 皓介, 古賀 友紹,甲斐 友佳理, Mary Ann Suico, 首藤 剛,甲斐 広文
  • Organizer: 第65回 日本薬理学会西南部会
  • Place of Presentation: 熊本大学(熊本)
  • Year and Date: 2012-11-23
• [Presentation] 新しい薬効評価モデル、気道粘液分泌亢進トランスジェニックマウスと去痰薬の再評価 (2012)
  • Author(s): 甲斐 広文
  • Organizer: 日本肺サーファクタン ト・ 界面医 学会 第48回学 術研究 会
  • Place of Presentation: 熊本市国際交流会館 (熊本)
  • Year and Date: 2012-10-27
• [Presentation] p53 regulates theEts transcription factor MEF/Elf4 viaMDM2 (2012)
  • Author(s): M. Suico, R. Miyakita, K. Koyama, M.Taura,T. Shuto, H. Kai
  • Organizer: ASCB 2012 Annual Meeting
  • Place of Presentation: Moscone Center, SanFrancisco(USA)
• [Presentation] 変異トランスサイレチンの翻訳後 N 型糖鎖修飾の意義とその制御因子の探索 (2012)
  • Author(s): 庄 美里, 佐藤 卓史, 西頭 英起,小亀 浩市, 金子 雅幸, 和田 郁夫,メ リー アン スイ コ, 首 藤 剛, 甲斐広文
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡国際会議場 (福岡)
• [Presentation] STT3B-dependentposttranslational N-glycosylation as asurveillance system for secretoryprotein (2012)
  • Author(s): Kai H, Sato T, Sho M, Sako Y, M. A. Suico, Shuto T
  • Organizer: Quality Control FromMolecules to Organelles
  • Place of Presentation: EMB Advenced TrainingCentre,Heidelberg(Germany)
• [Presentation] 変異トランスサイレチンの翻訳後N型糖鎖修飾の意義とその制御因子の探索 (2012)
  • Author(s): 庄 美里
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡国際会議場（福岡県）
• [Presentation] 慢性腎疾患Alport syndromeモデルマウスを用いた癌抑制遺伝子p53の腎保護的機能の解明 (2012)
  • Author(s): 福田 亮介
  • Organizer: 第65回日本薬理学会西南部会
  • Place of Presentation: 熊本大学薬学部（熊本県）
• [Presentation] 新しい薬効評価モデル、気道粘液分泌亢進トランスジェニックマウスと去痰薬の再評価 (2012)
  • Author(s): 甲斐 広文
  • Organizer: 日本肺サーファクタント・界面医学会 第４８回学術研究会
  • Place of Presentation: 熊本市国際交流会館（熊本）
  • Invited
• [Presentation] p53 regulates the Ets transcription factor MEF/Elf4 via MDM2. (2012)
  • Author(s): M. Suico
  • Organizer: ASCB 2012 Annual Meeting
  • Place of Presentation: San Francisco, CA, USA
• [Presentation] STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein (2012)
  • Author(s): Hirofumi Kai
  • Organizer: Quality Control From Molecules to Organelles
  • Place of Presentation: Heidelberg, Germany
• [Presentation] 遺伝性腎疾患および糖尿病性腎症に対する新たなphysical medicineの腎病態改善効果 (2012)
  • Author(s): 甲斐広文
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 北海道大学(北海道)
• [Presentation] Intracellular trafficking of amyloidogenic TTR and its therapeutic implications (2011)
  • Author(s): 甲斐広文
  • Organizer: The 27th International Kumamoto Medical Bioscience Symposium
  • Place of Presentation: 熊本大学(熊本)
  • Year and Date: 2011-11-23
• [Presentation] 翻訳後 N 型糖鎖修飾によるトランスサイレチンの新規小胞体品質管理機構 (2011)
  • Author(s): 庄 美里、佐藤 卓史、迫 康弘、桃原真美子、西頭 英起、金子 雅幸、メリーアン スイコ、首藤 剛、甲斐 広文
  • Organizer: 第28回日本薬学会九州支部大会
  • Place of Presentation: 福岡大学薬学部(福岡)
  • Year and Date: 2011-11-14
• [Presentation] アミロイド原性タンパク質の選択的分泌抑制を企図した創薬研究 (2011)
  • Author(s): 甲斐 広文
  • Organizer: 第5回薬学研究フォーラムin東京～九州からの情報発信～
  • Place of Presentation: 日本薬学会長井記念館(東京)
  • Year and Date: 2011-11-14
• [Presentation] 糖鎖型および脱糖鎖型 BCRP タンパク質の Derlin-1による負の翻訳後発現調節 (2011)
  • Author(s): 首藤 剛,杉山 崇,鈴木 伸悟,佐藤 卓史,古賀 友紹,Mary Ann Suico,楠原 洋之,杉山 雄一,甲斐 広文
  • Organizer: 第5回トランスポーター研究会九州部会
  • Place of Presentation: ホテル JAL シティ宮崎(宮崎)
  • Year and Date: 2011-09-17
• [Presentation] ABCトランスポーター ABCG5 および ABCG8 の小胞体における翻訳後発現制御機構の解明 (2011)
  • Author(s): 鈴木 伸悟,首藤 剛,佐藤 卓史,金子 雅幸,Mary Ann Suico,甲斐 広文
  • Organizer: 第5回トランスポーター研究会九州部会
  • Place of Presentation: ホテル JAL シティ宮崎(宮崎)
  • Year and Date: 2011-09-17
• [Presentation] HRD1-dependentendoplasmic reticulum-associateddegradation pathway is involved in theclearance of transthyretin variant (2011)
  • Author(s): M. Sho, T. Sato, Y. Sako, M. Momohara,H. Nishitoh, M. Kaneko, M. A. Suico, T.Shuto, H. Kai
  • Organizer: 5thInternational Congress on Stress Responsein Biology and Medicine
  • Place of Presentation: Loews Hotel Le Concorde,Quebec(USA)
• [Presentation] 糖鎖型および脱糖鎖型 BCRP タンパク質の Derlin-1による負の翻訳後発現調節 (2011)
  • Author(s): 首藤 剛,杉山 崇,鈴木 伸悟,佐藤 卓史,古賀 友紹,Mary Ann Suico,楠原 洋之,杉山 雄一,甲斐 広文
  • Organizer: 第6回トランスポーター研究会年会
  • Place of Presentation: 東北大学片平さくらホール(宮城県)
• [Presentation] Physical medicine-Basic and translational research on conditioned physical stress- (2011)
  • Author(s): Hirofumi Kai, Tatsuya Kondo, Saori Koga-Morino, Eiichi Araki
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川)
• [Presentation] Posttranslational regulation of ATP binding cassette transporter G5 and G8 by HRD1 (2010)
  • Author(s): Suzuki S, Shuto T, Sato T, Takada T, Kaneko M, Suico MA, Koga T, Morino S, Suzuki H, Kai H
  • Organizer: ASCB 50th annual meeting Philadelphia
  • Place of Presentation: PA, USA
• [Presentation] The role of HRD1 in intracellular trafficking of ATP binding cassette transporter G5 and G8. (2010)
  • Author(s): Suzuki S, Shuto T, Sato T, Takada T, Kaneko M, Suico MA, Koga T, Morino S, Suzuki H, Kai H
  • Organizer: The 3rd International Symposium on Protein Community
  • Place of Presentation: ホテル日航奈良
• [Presentation] Posttranslational regulation of ATP binding cassette transporter G5 and G8 by HRD1 (2010)
  • Author(s): Suzuki S, Shuto T, Sato T, Takada T, Kaneko M, Suico MA, Koga T, Morino S, Suzuki H, Kai H
  • Organizer: Global COE-IMEG Joint Summer Retreat Seminar
  • Place of Presentation: ホテルクリーンピア南阿蘇
• [Remarks]
  • URL: http://molmed730.org/
• [Remarks] 熊本大学大学院薬学教育部 遺伝子機能応用学研究室
  • URL: http://molmed730.org/index.html
• [Remarks]
  • URL: http://molmed730.org/
• [Remarks]
  • URL: http://molmed730.org/