Molecular mechanism that regulates neuronal layer formation and maintenance
Project/Area Number |
22390016
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Biological pharmacy
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Research Institution | Nagoya City University |
Principal Investigator |
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
|
Keywords | 脳 / タンパク質 / 遺伝子 / プロテアーゼ / 神経細胞 / 精神神経疾患 / 神経発生 / 細胞移動 / リーリン / 変異マウス / プロテオリシス / 発生 |
Research Abstract |
Reelin is essential for brain layer formation and maintenance. We identified the novel receptor molecule of Reelin that binds to its C-terminal region. We also identified the protease in charge of specific proteolysis of Reelin. Inhibiting this protease may increase Reelin function in adult brain and can be a new drug against neuropsychiatric disease.
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Report
(4 results)
Research Products
(109 results)
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[Journal Article] Dab1-mediated colocalization of multi-adaptor protein CIN85 with Reelin receptors, ApoER2 and VLDLR, in neurons.2013
Author(s)
Fuchigami, T., Sato, Y., Tomita, Y., Takano, T., Miyauchi, S.Y., Tsuchiya, Y., Saito, T., Kubo, K., Nakajima, K., Fukuda, M., Hattori, M., and Hisanaga, S.
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Journal Title
Genes Cells
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) cleaves Reelin in an isoform-dependent manner.2012
Author(s)
Hisanaga, A., Morishita, S., Suzuki, K., Sasaki, K., Koie, M., Kohno, T., and Hattori, M.
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Journal Title
FEBS Lett
Volume: 586
Pages: 3349-3353
Related Report
Peer Reviewed
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[Journal Article] Reelin controls neuronal migration and positioning by promoting neuronal adhesion to extracellular matrix via the inside-out activation of integrin α5β1.2012
Author(s)
Sekine, K., Kawauchi, T., Kubo, K., Honda, T., Herz, J., Hattori, M., Kinashi, T., and Nakajima, K.
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Journal Title
Neuron
Volume: 76
Pages: 353-369
Related Report
Peer Reviewed
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[Journal Article] LPIAT1 regulates arachidonic acid content in phosphatidylinositol and is required for cortical lamination in mice.2012
Author(s)
Lee, HC., Inoue, T., Sasaki, J., Kubo, T., Matsuda, S., Nakasaki, Y., Hattori, M., Tanaka, F., Udagawa, O., Kono, N., Itoh, T., Ogiso, H., Taguchi, R., Arita, N., Sasaki, T., and Arai, H.
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Journal Title
Mol. Biol. Cell
Volume: 23
Pages: 4689-4700
Related Report
Peer Reviewed
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[Journal Article] Reelin-dependent ApoER2 downregulation uncouples newborn neurons from progenitor cells.2012
Author(s)
Perez-Martinez, F. J., Luque-Rio, A,, Sakakibara, A., Hattori, M., Miyata, T., and Luque, J. M.
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Journal Title
Biol. Open
Volume: 1
Pages: 1258-1263
Related Report
Peer Reviewed
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[Journal Article] Differential localization of sphingomyelin synthase isoforms in neurons regulates sphingomyelin cluster formation. Biochem. Biophys.2012
Author(s)
Kidani, Y., Ohshima, K., Sakai, H., Kohno, T., Baba, A., & Hattori, M.
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Journal Title
Res. Commun.
Volume: 417
Pages: 1014-1017
Related Report
Peer Reviewed
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[Journal Article] Functional importance of covalent homodimer of reelin protein linked via its central region.2011
Author(s)
Yasui, N., Kitago, Y., Beppu, A., Kohno, T., Morishita, S., Gomi, H., Nagae, M., Hattori, M., & Takagi, J.
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Journal Title
J. Biol. Chem.
Volume: 286
Pages: 35247-35256
Related Report
Peer Reviewed
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[Journal Article] Mechanism of ER stress-induced brain damage by IP3 receptor.2010
Author(s)
Higo, T., Hamada, K., Hisatsune, C., Nukina, N., Hashikawa, T., Hattori, M., Nakamura, T., and Mikoshiba, K.
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Journal Title
Neuron
Volume: 68
Pages: 865-878
Related Report
Peer Reviewed
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[Presentation] Mechanism of specific proteolytic cleavage of Reelin.2011
Author(s)
Kidani, Y., Koie, M., Hisanaga, A., Kohno, T., & Hattori, M.
Organizer
41st Annual meeting of the Society for Neuroscience
Place of Presentation
Washington DC, USA
Year and Date
2011-11-16
Related Report
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[Presentation] Interaction between the dyslexia-associated protein KIAA0319 and radixin regulates neuronal morphology2011
Author(s)
Tagashira, M., Sugie, M., Kidani, Y., Kohno, T., & Hattori, M.
Organizer
41st Annual meeting of the Society for Neuroscience
Place of Presentation
Washington DC, USA
Year and Date
2011-11-13
Related Report
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[Presentation] リゾホスファチジルイノシトール特異的脂肪酸転移酵素LPIAT1の機能解析2011
Author(s)
李賢哲, 井上貴雄, 佐々木純, 中崎康子, 服部光治, 田中史晴, 宇田川理, 河野望, 伊藤俊樹, 小木曽英夫, 田口良, 佐々木雄彦, 新井洋由
Organizer
第83会日本生化学会大会
Place of Presentation
国立京都国際会館
Year and Date
2011-09-22
Related Report
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[Presentation] タイプ1型イノシトール3リン酸受容体欠損による小脳プルキンエ細胞の発火異常は、ジストニアを引き起こす2011
Author(s)
久恒智博, 宮本浩行, 廣野守俊, 山口直秀, 菅原健之, 小川直子, 大島登志男, 山田真久, ヘンシュ貴雄, 服部光治, 御子柴克彦
Organizer
第34回日本神経科学大会
Place of Presentation
パシフィコ横浜
Year and Date
2011-09-17
Related Report
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