Studies on conformational freedom-restricted cyclic amino acids - molecular design, synthesis, function, and drug design
| Project/Area Number |
22390022
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
TANAKA Masakazu 長崎大学, 医歯薬学総合研究科, 教授 (00227175)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2012: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Keywords | 生体分子 / 薬学 / 有機化学 / 生理活性 / アミノ酸 / ペプチド / コンフォメーション / フォールドマー / 環状アミノ酸 / ２次構造 / 非タンパク質構成アミノ酸 / 2次構造 |
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| Research Abstract |
Conformational freedom-restricted chiral cyclic amino acids have been designed and synthesized. The cyclic amino acids-containing oligopeptides were prepared by solution-phase methods or solid-phase methods, and their helical secondary structures were studied. The cyclic amino acid-containing nonapeptide was used as a catalyst for asymmetric epoxidation of various α,β-unsaturated ketones, and its α-helical secondary structure was studied by X-ray crystallographic analysis. Also, biologically activeoligopeptides having cyclic amino acids have been designed and synthesized.
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Report
(4 results)
Research Products
(79 results)
