Heparanase and extracellular matrices regulate cellular trafficking and function of inflammatory immune cells.
| Project/Area Number |
22390023
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HIGASHI Nobuaki 東京大学, 薬学研究科(研究院), 准教授 (40302616)
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| Project Period (FY) |
2010-04-01 – 2013-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2012: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Keywords | 微生物・感染症学 / 細胞外マトリックス / ヘパラナーゼ / ヘパラン硫酸 / 炎症 / マスト細胞 / ヘパリン / コラーゲン / 抗体医薬 / 顆粒球 / 敗血症 / 好中球 / 単球 |
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| Research Abstract |
Regulatory process of local inflammation is studied via degradation or downsizing of extracellular matrices by their degrading enzymes, especially on heparan sulfate and heparanase. Heparanase is involved in extravasation of neutrophils and monocytes in a local inflammation in mouse dorsal air pouches as well as in in vitro transmigration assay. Enzyme activity is likely to be regulated by differential localization of the enzyme molecules. Cleavage of granular heparin in the secretory granules of mast cells accelerates the release of granular materials from extracellular matrices. From the data, roles of heparanase are convincingly shown as a critical enzyme in induction and duration of inflammation.
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Report
(4 results)
Research Products
(48 results)
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[Journal Article] Heparanase-mediated cleavage of macromolecular heparin accelerates release of granular components of mast cells from extracellular matrices.2014
Author(s)
Higashi N, Waki M, Sue M, Kogane Y, Shida H, Tsunekawa N, Hasan A, Sato T, Kitahara A, Kasaoka K, Hayakawa Y, Nakajima M, Irimura T.
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Journal Title
Biochemical Journal
Volume: 458
Pages: 291-299
Related Report
Peer Reviewed
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[Journal Article] Loss of UDP-GalNAc : polypeptide N-acetylgalactosaminyltransferase 3 and reduced O-glycosylation in colon carcinoma cells selected for hepatic metastasis2010
Author(s)
Kato K, Takeuchi H, Kanoh A, Miyahara N, Nemoto-Sasaki Y, Morimoto-Tomita M, Matsubara A, Ohashi Y, Waki M, Usami K, Mandel U, Clausen H, Higashi N, Irimura T
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Journal Title
Glycoconj J
Volume: 27(2)(IF:1.882)
Pages: 437-445
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[Journal Article] Potentiation of proliferation of some but not all human colon carcinoma cell lines by immobilized hepatic asialoglycoprotein receptor 12009
Author(s)
Fang J, Izawa R, Gomez-Santos L, Ueno S, Sawaguchi T, Usami K, Nodera Y, Takeuchi H, Ohashi Y, Higashi N, Irimura T
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Journal Title
Oncol. Res
Volume: 17(10)(IF:1.634)
Pages: 437-445
Related Report
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[Journal Article] Heparanase-mediated cleavage of macromolecular heparin accelerates release of granular components of mast cells from extracellular matrices
Author(s)
Higashi N, Waki M, Sue M, Kogane Y, Shida H, Tsunekawa N, Hasan A, Sato T, Kitahara A, Kasaoka K, Hayakawa Y, Nakajima M, Irimura T
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Journal Title
Biochem J
Volume: (in press)(IF: 4.654)
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[Presentation] Heparanase regulates immune cell functions2011
Author(s)
Higashi N, Sasaki N, Komatsu N, Taka T, Waki M, Sue M, Kogane Y, Kolaczkowska E, Nishimura Y, Nakajima M, Irimura T
Organizer
Second Polish Congress of Biochemistry and Cell Biology
Place of Presentation
Krakow
Related Report
Invited
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