| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Research Abstract |
Glutamatergic (zincergic) neurons are concentrated in the hippocampus, where Zn2+plays an important role in memory acquisition. The accepted mechanisms of memory are synaptic plasticity. Long-term potentiation (LTP) is known as a cellular model of synaptic plasticity. Zn2+multi-functionally modulates LTP induction in the hippocampus and is involved in memory acquisition . However,dyshomeostasis of synaptic Zn2+in the hippocampus, which is induced by stress, is involved in the impairment of memory. The present study demonstrated that synaptic Zn2+participates in acquisition and impairment of memory .
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