Differentiation ofhuman iPS cells into hepatocytes and bile duct epithelial cells and application to drug development study
| Project/Area Number |
22390028
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Shinshu University |
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Principal Investigator |
OHMORI Shigeru 信州大学, 医学部附属病院, 教授 (70169069)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUNAGA Tamihide 名古屋市立大学, 薬学研究科, 教授 (40209581)
NAKAMURA Katsunori 名古屋市立大学, 薬学研究科, 准教授 (20361363)
YAMAORI Satoshi 信州大学, 医学部附属病院, 准教授 (40360218)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2012: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Keywords | 薬物動態 / 代謝学 / ヒト人工多能性幹細胞 / iPS細胞 / 肝細胞 / 腸管上皮細胞 / 低分子化合物 / 分化誘導 / 胆管上皮細胞 / ヒトES細胞 |
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| Research Abstract |
Human hepatocytes are useful for pharmacokinetic examinations. However, considerable donor-dependent variations are problematic. The small intestine, as well as liver, plays an important role in all aspects of pharmacokinetics. At present, human intestinal epithelial cells are difficult to obtain, and there is no appreciate model cells. Instead, other tissue cell-derived cell lines, including Caco-2 cells and MDCK cells, were used as intestinal model in a drug absorption study. Human iPS cells apparently differentiate into various types of mature cells, and are thereby an attractive source for routine access to large numbers of cells that can be used for the pharmacokinetic examinations replacing primary cells. In this study, we investigated the effects of small-molecule compounds for differentiation of human iPS cells into hepatocytes and enterocytes available in pharmacokinetic study.
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Report
(4 results)
Research Products
(51 results)
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[Presentation] Small molecule compounds enhance differentiation to hepatocytes from human induced pluripotent stem cells(低分子化合物はヒト人工多能性幹細胞から肝細胞への分化を促進する).2012
Author(s)
近藤祐樹,岩尾岳洋,吉橋幸美,三森佳代,杉山留理,佐々木崇光,永田 清,黒瀬光一,丹羽卓朗,山折 大,大森 栄,中村克徳,松永民秀
Organizer
日本薬物動態学会第27回年会
Place of Presentation
千葉
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