Construction of administration algorithm of novel oral molecular-targeted anti-cancer drugs based on the clarificationof interindividual differences of pharmacokinetics and pharmacodynamics
| Project/Area Number |
22390029
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
FUKUDO Masahide 京都大学, 医学系研究科, 助教 (60437233)
YANAGIHARA Kazuhiro 京都大学, 医学系研究科, 准教授 (70332731)
HATANO Etsuro 京都大学, 医学系研究科, 助教 (80359801)
UENO Takayuki 京都大学, 医学系研究科, 助教 (40452362)
KAMBA Tomomi 京都大学, 医学系研究科, 助教 (20402836)
TERAMUKAI Satoshi 京都大学, 医学系研究科, 准教授 (20359798)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2012: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
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| Keywords | 薬学 / 癌 / 薬剤反応性 / 分子標的抗がん剤 / がん |
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| Research Abstract |
We carried out clinical pharmacological studies for three kinds of novel oral molecular-targeted anti-cancer drugs. It has been demonstrated that sorafenib can be used safely and effectively for the hemodialyzed patient. We have also provided evidences that Breast Cancer Resistant Protein expressed in the intestine plays pivotal roles for regulatory factors for pharmacokinetic characteristics of sunitinib.Furthermore, we reported that erlotinib can be administered safely to non-small-cell lung cancer patients of malignant pleural effusion with respect to efficacy and side effects. These findings may be useful information to drive the personalized medicine of novel oral molecular-targeted anti-cancer drugs
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Report
(4 results)
Research Products
(58 results)
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[Journal Article] Heterozygous variants of multidrug and toxin extrusions(MATE1 and MATE2-K) have little influence on the disposition of metformin in diabetic patients2010
Author(s)
Toyama K, Yonezawa A, Tsuda M, Masuda S, Yano I, Terada T, Osawa R, Katsura T, Hosokawa M, Fujimoto S, Inagaki N, Inui K
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Journal Title
Pharmacogenet. Genomics
Volume: 20(2)
Issue: 2
Pages: 135-138
DOI
Related Report
Peer Reviewed
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[Journal Article] Population pharmacokinetics/pharmacodynamics of erlotinib and pharmacogenomic analysis of plasma and cerebrospinal fluid drug concentrations in Japanese patients with non-small cell lung cancer
Author(s)
Fukudo, M., Ikemi, Y., Togashi, Y., Masago, K., Kim, Y.H., Mio, T., Terada, T., Teramukai, S.
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Journal Title
Clin. Pharmacokinet
Volume: (in press)
Related Report
Peer Reviewed
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