| Project/Area Number |
22390037
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Ehime University |
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Principal Investigator |
TANAKA Junya 愛媛大学, プロテオ医学研究センター, 教授 (70217040)
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| Co-Investigator(Kenkyū-buntansha) |
YANO Hajime 愛媛大学, 大学院・医学系研究科, 准教授 (00284414)
TAKAHASHI Hisaaki 愛媛大学, 医学部附属病院, 講師 (20363228)
SUGIMOTO Kana 愛媛大学, 大学院・医学系研究科, 助教 (00581034)
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| Co-Investigator(Renkei-kenkyūsha) |
OHNISHI Takanori 愛媛大学, 大学院・医学系研究科, 教授 (70233210)
KUMON Yoshiaki 愛媛大学, 大学院・医学系研究科, 准教授 (80127894)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2012: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
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| Keywords | マクロファージ / マイクログリア / 骨髄 / 分化多能性 / 神経細胞保護作用 / 単球 / BINCs / 脳梗塞 / NG2 / パーキンソン病 / 新規治療法 / 幹細胞性 / 脳損傷 / Iba1 / サイトカイン / 分化誘導 |
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| Research Abstract |
Many bone marrow-derived macrophages were found to accumulate in lesion cores of stroke and traumatic brain injuries. Because most of the cells expressed a multipotent cell marker in the brain, NG2 chondroitin sulfate proteoglycan as well as a macrophage marker Iba1, they were termed BINCs (Brain Iba1^+/NG2^+Cells). BINCs exerted neuroprotective actions and promoted regeneration and restoration of injured tissue by releasing neuroprotective growth factors and scavenging degenerated cellsand tissues. We found that injection of a cytokine mixture (IL3 and GM-CSF) markedly ameliorated traumatic brain injury and Parkinson’s disease.
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