Strategy for treatment of diseases by cell type specific invasive peptides

• Project/Area Number: 22390038
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General physiology
• Research Institution: University of the Ryukyus
• Principal Investigator: MATSUSHITA Masayuki 琉球大学, 大学院・医学研究科, 教授 (30273965)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Mariko 琉球大学, 大学院・医学研究科, 准教授 (40180400) ; SUNAGAWA Masanori 琉球大学, 大学院・医学研究科, 助教 (70325835)
• Co-Investigator(Renkei-kenkyūsha): KONDO Eisaku 愛知県がんセンター研究所, 腫瘍病理部, 部長 (30252951)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000); Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2011: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000); Fiscal Year 2010: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
• Keywords: ペプチド / 癌 / イメージング / 先進医療 / DDS / 分子標的 / 創薬 / 脳 / シグナル / 細胞膜

Research Abstract

We identify novel cell penetrating peptides (CPPs) that are selectively and efficiently incorporated into human tumor cells according to their lineage. Thus, we established the novel technology that isolation of tumor lineage-homing CPPs from a random peptide library generated by mRNA display method.

Research Products

• [Journal Article] Tumour lineage-homing cell-penetrating peptides as anticancer molecular delivery systems (2012)
  • Author(s): Kondo E, Saito K, Tashiro Y, Kamide K, Uno S, Furuya T, Mashita M, Nakajima K, Tsumuraya T, Kobayashi N, Nishibori M, Tanimoto M, Matsushita M
  • Journal Title: Nature Communications Volume: 3 Issue: 1 Pages: 951-951
  • DOI: 10.1038/ncomms1952
  • Peer Reviewed
• [Journal Article] Transformation of eEF1Bdelta into heat shock response transcription factor by alternative splicing (2011)
  • Author(s): Kaitsuka T, Tomizawa K, Matsushita M
  • Journal Title: EMBO reports Volume: 12 Issue: 7 Pages: 673-681
  • DOI: 10.1038/embor.2011.82
  • Peer Reviewed
• [Journal Article] MicroRNA 130 Family Regulates the Hypoxia Response Signal through the P-body Protein DDX6 (2011)
  • Author(s): Saito K, Kondo E, Matsushita M
  • Journal Title: Nucleic Acids Research Volume: 39 Issue: 14 Pages: 6086-6099
  • DOI: 10.1093/nar/gkr194
  • Peer Reviewed
• [Journal Article] OGFOD1, a member of the 2-Oxoglutarate and Iron Dependent Dioxygenase Family, Functions in Ischemic Signaling (2011)
  • Author(s): Saito K
  • Journal Title: FEBS Letters Volume: 584 Pages: 3340-3347
  • Peer Reviewed
• [Journal Article] MicroRNA 130 Family Regulates the Hypoxia Response Signal through the P-body Protein DDX6 (2011)
  • Author(s): Saito K
  • Journal Title: Nucleic Acids Research Volume: (印刷中)
  • Peer Reviewed
• [Presentation] 細胞選択的侵入ペプチドによる疾患治療戦略 (2011)
  • Author(s): シンポジウム:松下正之
  • Organizer: 第88回日本生理学会大会・第116回日本解剖学会総会全国学術集会合同大会
  • Place of Presentation: 横浜(東日本大震災のため誌上発表)
  • Year and Date: 2011-03-28
• [Remarks]
  • URL: http://ryukyu-physiology.info/
• [Patent(Industrial Property Rights)] 癌細胞選択的膜透過性ペプチドおよびその利用 (2011)
  • Inventor(s): 松下正之、近藤英作
  • Industrial Property Rights Holder: 三菱化学、愛知県
  • Filing Date: 2011-04-05
  • Overseas