Vascular stabilization and destabilization by angiopoietin-1/Tie2 system
| Project/Area Number |
22390040
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
FUKUHARA Shigetomo 独立行政法人国立循環器病研究センター, 研究所, 室長 (70332880)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
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| Keywords | アンジオポエチン / Tie2 / 血管新生 / 血管安定化 / Tie-2 / アンンジオポエチン |
|---|
| Research Abstract |
In this study, we investigated the mechanism how Angiopoietin-1 (Ang1)-Tie2 signal promotes vascular stabilization. Here, we show that Ang1-Tie2 signal potentiates Notch signal through β-catenin-dependent up-regulation of Delta-like 4 expression, leading to basement membrane formation required for vascular stabilization. In addition, we report that Ang1-Tie2 signal induces reorganization of actin cytoskeleton through Rap1 small GTPase, thereby enhancing endothelial barrier function.
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Report
(4 results)
Research Products
(58 results)
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[Journal Article] Arhgef15 promotes retinal angiogenesis by mediating VEGF-induced Cdc42 activation and potentiating RhoJ inactivation in endothelial cells.2012
Author(s)
Kusuhara S., Fukushima Y., Fukuhara S., Jakt L.M., Okada M., Shimizu Y., Hata M., Nishida K., Negi A., Hirashima M., Mochizuki N., Nishikawa S. and Uemura A.
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Journal Title
PLoS One
Volume: 7
Issue: 9
Pages: e45858-e45858
DOI
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Peer Reviewed
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[Presentation] Signaling pathways regulating endothelial barrier functions2010
Author(s)
Shigetomo Fukuhara, Koji Ando, Kazuomi Noda, Jianghui Zhang, Naoki Mochizuki
Organizer
The 8th Korea-Japan Joint Symposium on Vascular Biology & The 18th Annual Meeting of the Japanese Vascular Biology and Medicine Organization. Symposium.
Place of Presentation
Osaka, Japan
Year and Date
2010-12-03
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