|Budget Amount *help
¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
In this study, we investigated the mechanism how Angiopoietin-1 (Ang1)-Tie2 signal promotes vascular stabilization. Here, we show that Ang1-Tie2 signal potentiates Notch signal through β-catenin-dependent up-regulation of Delta-like 4 expression, leading to basement membrane formation required for vascular stabilization. In addition, we report that Ang1-Tie2 signal induces reorganization of actin cytoskeleton through Rap1 small GTPase, thereby enhancing endothelial barrier function.