Novel functional linkages of drinking・feeding behavior and TRP channels: Clarification by the post-genome approach
Project/Area Number |
22390044
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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Research Institution | University of Occupational and Environmental Health, Japan |
Principal Investigator |
UETA Yoichi 産業医科大学, 医学部, 教授 (10232745)
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Co-Investigator(Kenkyū-buntansha) |
FUJIHARA Hiroaki 徳島大学, 大学院ヘルスバイオサイエンス研究部, 助教 (10369051)
ISHIKURA Toru 産業医科大学, 医学部, 助教 (70580281)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2012: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2010: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
|
Keywords | 飲水行動 / 摂食行動 / TRPチャネル / ペプチド / 遺伝子改変動物 / Fosタンパク / 浸透圧感受性 / TRPV1 / TRPV4 / TRPA1 / ノックアウトマウス |
Research Abstract |
The purpose of the study was to investigate the roleof TRP channels known as osmotic sensors, using TRPV1 and TRPV4 knockout mice in comparison with wild type concerning about the feeding and drinking behavior. We revealed that TRPV1 and TRPV4 channels concerned drinking behavior and water and food intake after water deprivation.
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Report
(4 results)
Research Products
(60 results)
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[Journal Article] Induction of arginine vasopressin-enhanced green fluorescent protein expression in the locus coeruleus following kainic acid-induced seizures in rats2012
Author(s)
Ohno, M. Fujihara, H. Iwanaga, M. Todoroki, M. Katoh, A. Ohbuchi, T. Ishikura, T. Hamamura, A. Hachisuka, K. & Ueta, Y
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Journal Title
Stress
Volume: 15(4)
Issue: 4
Pages: 435-442
DOI
Related Report
Peer Reviewed
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[Journal Article] Expression of the c-fos-monomeric red fluorescent protein l fusion gene in the spinal cord and the hypothalamic paraventricular nucleus in transgenic rats after formalin injection2012
Author(s)
Ishikura, T. Suzuki, H. Yoshimura, M. Ohkubo, J. Katoh, A. Ohbuchi, T. Ohno, M.Fujihara, H. Kawasaki, M. Ohnishi,H. Nakamura, T. & Ueta, Y
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Journal Title
Brain Research
Volume: 1479
Pages: 52-61
DOI
Related Report
Peer Reviewed
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[Journal Article] Central diabetes insipidus associated with impaired renal aquaporin-1 expression in mice lacking liver X receptorβ2012
Author(s)
Gabbi C, Kong X, Suzuki H, Kim HJ, Gao M, Jia X, Ohnishi H, Ueta Y, Warner M, Guan Y, Gustafsson JÅ
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Journal Title
Proc Natl Acad Sci USA
Volume: 109(8)
Issue: 8
Pages: 3030-3034
DOI
Related Report
Peer Reviewed
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[Journal Article] Central diabetes insipidus associated with impaired renal aquaporin-1 expression in mice lacking liver X receptor β2012
Author(s)
Gabbi, C., Kong, X., Suzuki, H., Kim, HJ., Gao, M., Jia, X., Ohnishi, H., Ueta, Y., Warner, M., Guan, Y., Gustafsson, JA.
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Journal Title
Proceedings of the National Academy of Sciences USA
Volume: 109(8)
Pages: 3030-3034
Related Report
Peer Reviewed
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[Journal Article] Angiotensin II type 1 receptor signaling regulates feeding behavior through anorexigenic corticotropin-releasing hormone in hypothalamus2011
Author(s)
Yamamoto, R. Akazawa, H. Fujihara, H. Ozasa, Y. Yasuda, N. Ito, K. Kudo, Y. Qin, Y. Ueta, Y. & Komuro, I
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Journal Title
Journal of Biological Chemistry
Volume: 286(24)
Issue: 24
Pages: 21458-21465
DOI
Related Report
Peer Reviewed
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[Presentation] Neuroendocrine regulatory peptide-3 : anatomical distributions in the hypothalatnus and physiological role on the hypothalamo-neurohypophysial system in rats2011
Author(s)
Ueta, Y., Fujihara, H., Mishiro-Sato, E., Sasaki, K., Ohbuchi, T., Dayanithi, G., Yamasaki, M., Minamino, N.
Organizer
9^<th> World Congress on Neurohypophysial Hormones
Place of Presentation
Northeastern University (Boston, USA)
Related Report
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[Presentation] Expression of Fos protein in the spinal cord and hypothalamus after acute arthritis in the c-fos-monomeric red fluorescent protein transgenic rats2011
Author(s)
Ishikura, T., Suzuki, H., Ohnishi, H., Nakamura, T., Ueta, Y.
Organizer
SICOT 2011
Place of Presentation
Prague Congress Centre (Prague, Czech Republic)
Related Report
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