Roles of the prostanoids in the pathogenesis of cardiovascular diseases

• Project/Area Number: 22390045
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General pharmacology
• Research Institution: Asahikawa Medical College
• Principal Investigator: USHIKUBI Fumitaka 旭川医科大学, 医学部, 教授 (50243035)
• Co-Investigator(Kenkyū-buntansha): KOJIMA Fumiaki 旭川医科大学, 医学部, 助教 (30550545) ; KASHIWAGI Hitoshi 旭川医科大学, 医学部, 助教 (60510609) ; YUHKI Koh-ichi 旭川医科大学, 医学部, 准教授 (80302420)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000); Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2011: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2010: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
• Keywords: プロスタノイド / プロスタグランジン / トロンボキサン / 循環器 / 循環器系疾患 / 循環器疾患 / 心筋梗塞 / 腎線維化 / 脳血栓 / 血小板

Research Abstract

To clarify the roles of the prostanoids in the cardiovascular system, we employed several animal models showing similar pathophysiology with those seen in human diseases. Through the analysis of these animal models, we found novel actions of the prostanoids, which include the role of the EP4 and IP in the development of renal interstitial fibrosis, the role of the EP1 in the development of cisplatin-induced nephropathy and the potent inhibitory action of ONO1301 on platelet aggregation._4 Au

Research Products

• [Journal Article] Prostacyclin stimulated integrin-dependent angiogenic effects of endothelial progenitor cells and mediated potent circulation recovery in ischemic hind limb model (2013)
  • Author(s): Aburakawa Y, Yuhki K, Ushikubi F, Hasebe N, et al
  • Journal Title: Circ J Volume: 77 Pages: 1053-1062
  • NAID: 10031139011
• [Journal Article] 17β-Estradiol is critical for the preovulatory induction of prostaglandin E_2 synthesis in mice (2012)
  • Author(s): Toda K, Yuhki K, Ushikubi F, Saibara T, et al
  • Journal Title: J Gastroenterol. In press. Mol Cell Endocrinol Volume: 362 Pages: 176-182
• [Journal Article] The intrinsic prostaglandin E_2-EP_4 system of the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice (2012)
  • Author(s): Nakagawa N, Yuhki K, Kojima F, Kashiwagi H, Ushikubi F, et al
  • Volume: 82
  • Pages: 158-171
• [Journal Article] The intrinsic prostaglandin E(2)-EP(4) system of the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice (2012)
  • Author(s): Nakagawa N, Yuhki KI, Kawabe JI, Fujino T, Takahata O, 他9名
  • Journal Title: Kidney Int Volume: (in press) Issue: 2 Pages: 158-171
  • DOI: 10.1038/ki.2012.115
  • Peer Reviewed
• [Journal Article] The intrinsic prostaglandin E2-EP4 system of the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice (2012)
  • Author(s): Nakagawa N, Yuhki K, et al.
  • Journal Title: Kidney International Volume: (in press)
  • Peer Reviewed
• [Journal Article] Potential roles of microsomal prostaglandin E synthase-1 in rheumatoid arthritis (2011)
  • Author(s): Kojima F, Ushikubi F, Crofford LJ, et al
  • Journal Title: Inflamm Regen Volume: 31 Pages: 157-166
  • NAID: 130004943782
• [Journal Article] Thromboxane receptor activation enhances striatal dopamine release, leading to suppression of GABAergic transmission and enhanced sugar intake (2011)
  • Author(s): Mitsumori T, Ushikubi F, Narumiya S, et al
  • Journal Title: Eur J Neurosci Volume: 34 Pages: 594-604
• [Journal Article] Roles of prostanoids in the pathogenesis of cardiovascular system: Novel insights from knockout mouse studies (2011)
  • Author(s): Yuhki K, Kojima F, Kashiwagi H, Ushikubi F, et al
  • Journal Title: Pharmacol Ther Volume: 129 Pages: 195-205
• [Journal Article] Selective activation of the prostaglandin E_2 receptor subtype EP_2 or EP_4 leads to inhibition of platelet aggregation (2010)
  • Author(s): Kuriyama S, Kashiwagi H, Yuhki K, Kojima F, Ushikubi F, et al
  • Journal Title: Thromb Haemost Volume: 104 Pages: 796-803
• [Journal Article] Selective activation of the prostaglandin E2 receptor subtype EP2 or EP4 leads to inhibition of platelet aggregation (2010)
  • Author(s): Kashiwagi, H., et al.
  • Journal Title: Thrombosis and Haemostasis Volume: 104 Pages: 796-803
  • Peer Reviewed
• [Journal Article] M1 is a major subtype of muscarinic acetylcholine receptors on mouse colonic epithelial cells
  • Author(s): Khan MR , Ushikubi F, Taniguchi T, et al
  • Journal Title: J Gastroenterol Volume: (in press)
  • NAID: 10031195115
• [Presentation] シスプラチン誘発急性腎障害におけるプロスタグランジンE2受容体サブタイプEP1の役割 (2013)
  • Author(s): 小島史章
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡
• [Presentation] Inhibition of thromboxane A2 synthase prevents reduction in the anti-platelet effect of a prostaglandin I2 receptor agonist after repeated administration (2012)
  • Author(s): 柏木仁
  • Organizer: 日本薬理学会
  • Place of Presentation: 京都
  • Year and Date: 2012-03-14
• [Presentation]
  • Organizer: 日本薬理学会総会・北部会