Functional analysis of IFITM3 in neurodevelopmental impairments
| Project/Area Number |
22390046
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIZOGUCHI Hiroyuki 名古屋大学, 環境医学研究所, 助教 (70402568)
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| Co-Investigator(Renkei-kenkyūsha) |
NAGAI Taku 名古屋大学, 医学部附属病院, 准教授 (10377426)
HIBI Yoko 名古屋大学, 医学部附属病院, 特任助教 (70295616)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
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| Keywords | 神経発達障害 / 統合失調症 / アストログリア細胞 / 神経-グリア相互作用 / polyI:C / IFITM3 / エンドサイトーシス / 神経－グリア相互作用 / アストログリア / 動物モデル / 炎症性サイトカイン / D-セリン |
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| Research Abstract |
The role of interferon-induced transmembrane protein 3 (IFITM3) in the CNS is largely unknown, despite the fact that its expression is increased in the brains of patients with neurologic and neuropsychiatric diseases. In the present study we show the role of IFITM3 in long-lasting neuronal impairments in mice following polyI:C-induced immune challenge during the early stages of development. Our findings suggest that the induction of IFITM3 expression in astrocytes by the activation of the innate immune system during the early stages of development has non-cell autonomous effects that affect subsequent neurodevelopment, leading to neuropathological impairments and brain dysfunction, by impairing endocytosis in astrocytes.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice2013
Author(s)
D Ibi, I Nagai, A Nakajima, H Mizoguchi, T Kawase, D Tsuboi, S Kano, Y Sato, M Hayakawa, U. C. Lange, D. J. Adams, M. Azim Surani, T Satoh, A Sawa, K Kaibuchi, T Nabeshima and K Yamada
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Journal Title
Glia
Volume: 61
Issue: 5
Pages: 679-693
DOI
Related Report
Peer Reviewed
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[Journal Article] Matrix metalloproteinase-9 contributes to kindled seizure development in pentylenetetrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus2011
Author(s)
H Mizoguchi, J Nakade, M Tachibana, D Ibi, E Someya, H Koike, H Kamei, T Nabeshima, S Itohara, K Takuma, M Sawada, J Sato, K Yamada
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Journal Title
Journal of Neuroscience
Volume: 31
Issue: 36
Pages: 12963-12971
DOI
Related Report
Peer Reviewed
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[Presentation]2012
Author(s)
Yamada K, Ibi D, Nakajima A, Yamada S, Mizoguchi H, Nabeshima T and Nagai T
Organizer
8thFENS Forum of Neuroscience
Place of Presentation
Barcelona International Convention Center
Related Report
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[Presentation]2012
Author(s)
山田清文
Organizer
第86回日本薬理学会年会
Place of Presentation
福岡 福岡国際会議場
Related Report
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[Presentation]2011
Author(s)
Yamada K.
Organizer
Society of Biological Psychiatry 66thAnnual Scientific Meeting & Convention
Place of Presentation
San Francisco Hyatt Regency, Embarcadero Center
Related Report
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