Pharmacogenomic study on the drug-sensitive genes using model organisms
| Project/Area Number |
22390048
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General pharmacology
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
KUNO Takayoshi 神戸大学, 医学研究科, 特命教授 (50144564)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MA Yan 神戸大学, 医学研究科, 講師 (70457050)
MUKAI Hideyuki 神戸大学, バイオシグナル研究センター, 准教授 (80252758)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2011: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2010: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
|
|---|
| Keywords | 免疫抑制薬 / 抗真菌薬 / ストレス応答 / 細胞内情報伝達 / 細胞内輸送 / モデル生物 / スタチン / コレステロール / がん遺伝子 / GPIアンカー / コバルト / マップキナーゼ / アゾール系 / 薬剤耐性 / 薬剤感受性 / 細胞内カルシウム / チャネル / バルプロ酸 / 低分子量GTP結合タンパク質 / グアニンヌクレオチド交換因子 / 酸化ストレス / 転写因子 |
|---|
| Research Abstract |
In this study we performed many experiments to clarify the molecular mechanisms of adverse action of drugs as well as to overcome the drug resistance. For this purpose we genetically analyzed various fission yeast mutant strains that show hypersensitivity or resistance to various drugs. As results, we identified various genes that are responsible for the changes in the drug sensitivity. These results will be helpful to reduce the adverse effects of immunosuppressants, to identify novel target molecules for antifugal drugs, to overcome the drug resistance, or to find a new clinical application of valproic acid.
|
Report
(4 results)
Research Products
(25 results)
