Mechanism underlying the regulation of brain function through sphingosine kinase/S1P signaling

• Project/Area Number: 22390053
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General medical chemistry
• Research Institution: Kobe University
• Principal Investigator: NAKAMURA Shunichi 神戸大学, 大学院・医学研究科, 教授 (40155833)
• Co-Investigator(Kenkyū-buntansha): OKADA Taro 神戸大学, 大学院・医学研究科, 准教授 (80304088) ; KAJIMOTO Taketoshi 神戸大学, 大学院医学研究科, 助教 (00509953)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2010: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
• Keywords: 分子病態学 / スフィンゴシンキナーゼ / スフィンゴシン1リン酸 / 海馬 / 神経伝達物質 / グルタミン酸 / GABA / スフィンゴシン1燐酸(SIP)

Research Abstract

Electrophysiological studies demonstrated that S1P signaling causes glutamate release from mossy fiber teminals in the hippocampus as well as it doesfrom hippocampal neurons, suggesting that this signaling system may regulate memory formation and learning in the brain. Immunohistochemical analysis revealed that sphingosine kinase 1 is rich in cerebellum and substantia nigra as well as mossy fibers in the hippocampussuggesting the signaling system may work in GABAnergic and dopaminergic neurons as well.Further studies are necessary to elucidate the function of S1P in the brain.

Research Products

• [Journal Article] 細胞内外で機能するスフィンゴシン1リン酸(S1P)の役割 (2012)
  • Author(s): 岡田太郎、中村俊一
  • Journal Title: 生化学 Volume: 84 Pages: 92-101
  • NAID: 10030346307
• [Journal Article] Regulation of synaptic strength by sphingosine 1-phosphate in the hippocampus. (2010)
  • Author(s): Kanno, T., Nishizaki, T., Proia, R. L., Kajimoto, T., Jahangeer, S., Okada, T., & Nakamura, S.
  • Journal Title: Neurosci Volume: 171 Pages: 973-980
  • Peer Reviewed
• [Journal Article] Sphingosine kinase 1 regulates mucin production via ERK phosphorylation (2010)
  • Author(s): Kono, Y., Nishiuma, T., Okada, T., Kobayashi, K., Funada, Y., Kotari, Y., Jahangeer, S., Nakamura S., Nishimura Y.
  • Journal Title: Pulm.Pharmacol.Ther. Volume: 23 Pages: 36-42
  • NAID: 120003290046
  • Peer Reviewed
• [Journal Article] Yasutomi Nishizuka : father of protein kinase C (2010)
  • Author(s): Nakamura, S., Yamamura, H.
  • Journal Title: J.Biochem. Volume: 148 Pages: 125-130
  • NAID: 10027877356
  • Peer Reviewed
• [Journal Article] Regulation of synaptic strength by sphingosine 1-phosphate in the hippocampus (2010)
  • Author(s): Kanno, T., Nishizaki, T., Proia, L., Kajimoto, T., Jahangeer, S., Okada., T., Nakamura, S
  • Journal Title: Neuroscience Volume: 171 Pages: 7-13
  • Peer Reviewed
• [Presentation] Sphingosine kinase (2013)
  • Author(s): 中村俊一
  • Organizer: Workshop on Innovation and Pioneering Technology 2012
  • Place of Presentation: 神戸
  • Invited
• [Presentation] Sphingolipid signaling and neuronal function (2011)
  • Author(s): Nakamura, S., Fukai, E., Miya, S., Jesko, H., & Okada, T.
  • Organizer: 52nd International Conference onthe Bioscience of Lipids
  • Place of Presentation: Warsaw, Poland
  • Year and Date: 2011-09-02
• [Presentation] Sphingolipid signaling and neuronal function (2011)
  • Author(s): Nakamura, S., Fukai, E., Miya, S., Jesko, H., Okada, T.
  • Organizer: 52^<nd> International Conference on the Bioscience of Lipids
  • Place of Presentation: ワルシャワ(ポーランド)(招待講演)
  • Year and Date: 2011-08-03
• [Presentation] Regulation of hippocampal function by sphingolipid signaling (2011)
  • Author(s): Nakamura, S.
  • Organizer: International Symposium on Cell Signaling and Gene Regulation
  • Place of Presentation: Taiwan
  • Year and Date: 2011-02-20
• [Presentation] Nakamura, S., Fukai, E., Jesko, H., & Okada, T. (2010)
  • Author(s): Nakamura, S., Fukai, E., Jesko, H., & Okada, T.
  • Organizer: 第83回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-08
• [Book] スフィンゴシン1リン酸の機能、セラミド-基礎と応用- (2011)
  • Author(s): 中村俊一
  • Publisher: セラミド研究会編
• [Book] セラミド:基礎と応用 (2011)
  • Author(s): 中村俊一
  • Total Pages: 237
  • Publisher: 食品化学新聞社
• [Remarks] ホームページ
  • URL: http://www.med.kobe-u.ac.jp/gs/field/basic/biochem.html
• [Remarks]
  • URL: http://www.med.kobe-u.ac.jp/biochemistry/publication.html