Mechanism underlying the regulation of brain function through sphingosine kinase/S1P signaling
Project/Area Number |
22390053
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General medical chemistry
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Research Institution | Kobe University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
OKADA Taro 神戸大学, 大学院・医学研究科, 准教授 (80304088)
KAJIMOTO Taketoshi 神戸大学, 大学院医学研究科, 助教 (00509953)
|
Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
|
Keywords | 分子病態学 / スフィンゴシンキナーゼ / スフィンゴシン1リン酸 / 海馬 / 神経伝達物質 / グルタミン酸 / GABA / スフィンゴシン1燐酸(SIP) |
Research Abstract |
Electrophysiological studies demonstrated that S1P signaling causes glutamate release from mossy fiber teminals in the hippocampus as well as it doesfrom hippocampal neurons, suggesting that this signaling system may regulate memory formation and learning in the brain. Immunohistochemical analysis revealed that sphingosine kinase 1 is rich in cerebellum and substantia nigra as well as mossy fibers in the hippocampussuggesting the signaling system may work in GABAnergic and dopaminergic neurons as well.Further studies are necessary to elucidate the function of S1P in the brain.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Regulation of synaptic strength by sphingosine 1-phosphate in the hippocampus.2010
Author(s)
Kanno, T., Nishizaki, T., Proia, R. L., Kajimoto, T., Jahangeer, S., Okada, T., & Nakamura, S.
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Journal Title
Neurosci
Volume: 171
Pages: 973-980
Related Report
Peer Reviewed
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[Journal Article] Sphingosine kinase 1 regulates mucin production via ERK phosphorylation2010
Author(s)
Kono, Y., Nishiuma, T., Okada, T., Kobayashi, K., Funada, Y., Kotari, Y., Jahangeer, S., Nakamura S., Nishimura Y.
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Journal Title
Pulm.Pharmacol.Ther.
Volume: 23
Pages: 36-42
NAID
Related Report
Peer Reviewed
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[Journal Article] Regulation of synaptic strength by sphingosine 1-phosphate in the hippocampus2010
Author(s)
Kanno, T., Nishizaki, T., Proia, L., Kajimoto, T., Jahangeer, S., Okada., T., Nakamura, S
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Journal Title
Neuroscience
Volume: 171
Pages: 7-13
Related Report
Peer Reviewed
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[Presentation] Sphingolipid signaling and neuronal function2011
Author(s)
Nakamura, S., Fukai, E., Miya, S., Jesko, H., & Okada, T.
Organizer
52nd International Conference onthe Bioscience of Lipids
Place of Presentation
Warsaw, Poland
Year and Date
2011-09-02
Related Report
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[Presentation] Nakamura, S., Fukai, E., Jesko, H., & Okada, T.2010
Author(s)
Nakamura, S., Fukai, E., Jesko, H., & Okada, T.
Organizer
第83回日本生化学会大会
Place of Presentation
神戸
Year and Date
2010-12-08
Related Report
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