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Molecular mechanism underlying liver stem cell system

Research Project

Project/Area Number 22390054
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General medical chemistry
Research InstitutionKyushu University

Principal Investigator

SUZUKI Atsushi  九州大学, 生体防御医学研究所, 准教授 (30415195)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2012: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2011: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2010: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywords幹細胞 / 肝臓 / 発生 / 再生医学 / がん / 再生 / 癌
Research Abstract

The study of tissue-specific stem cells is important for the development of regenerative medicine and cancer therapy. In this study, we sought to clarify the molecular mechanism regulating differentiation and proliferation of hepatic stem cells in liver development, regeneration and carcinogenesis. Our study revealed mechanisms underlying not only differentiation of hepatic stem cells, but also proliferation of differentiated hepatocytes in liver regeneration after loss of liver mass or hepatic injury. Moreover, although intrahepatic cholangiocarcinoma has been known to originate from malignant transformation of intrahepatic cholangiocytes, we found that intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytes. These findings will contribute to the development of therapeutic strategies for liver diseases

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (43 results)

All 2013 2012 2011 2010 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (28 results) (of which Invited: 5 results) Book (6 results) Remarks (4 results)

  • [Journal Article] Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytes2012

    • Author(s)
      Sekiya S. and Suzuki A
    • Journal Title

      J Clin Invest

      Volume: 122 Pages: 3914-3918

    • URL

      http://www.jci.org/articles/view/63065

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors2011

    • Author(s)
      Sekiya S. and Suzuki A
    • Journal Title

      Nature

      Volume: 475 Issue: 7356 Pages: 390-393

    • DOI

      10.1038/nature10263

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glycogen synthase kinase 3β-dependent Snail degradation directs hepatocyte proliferation in normal liver regeneration2011

    • Author(s)
      Sekiya S. and Suzuki A
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 108 Issue: 27 Pages: 11175-11180

    • DOI

      10.1073/pnas.1016122108

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver2011

    • Author(s)
      Onoyama I., Suzuki A., Matsumoto A., Tomita K., Katagiri H., Oike Y., Nakayama K., Nakayama K.I
    • Journal Title

      J Clin Invest

      Volume: 121 Issue: 1 Pages: 342-354

    • DOI

      10.1172/jci40725

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver2011

    • Author(s)
      Onoyama, et al.
    • Journal Title

      Journal of Clinical Investigation

      Volume: 121 Pages: 342-354

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 特定因子による皮膚細胞から肝細胞への直接転換2012

    • Author(s)
      鈴木淳史
    • Organizer
      第35回日本分子生物学会年会ワークショップ「転写因子による細胞運命の直接転換」
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-13
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] ヘテロクロニック遺伝子群による肝芽細胞の増殖の制御2012

    • Author(s)
      高島康郎、鈴木淳史
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-12
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 肝細胞誘導におけるリプログラミング過程の観察と解析2012

    • Author(s)
      三浦静、関谷明香、鈴木淳史
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-12
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Directed cell fate reprogramming of mouse fibroblasts to hepatocyte-like cells2012

    • Author(s)
      Suzuki A
    • Organizer
      ISSCR-Roddenberry International Symposium on Cellular Reprogramming
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2012-10-25
    • Related Report
      2012 Final Research Report
  • [Presentation] Directed cell fate reprogramming of mouse fibroblasts to hepatocyte-like cells2012

    • Author(s)
      Suzuki A
    • Organizer
      Asia-Pacific Developmental Biology Conference 2012
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2012-10-07
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 肝臓の再生と疾患に関わる肝細胞の運命転換2012

    • Author(s)
      鈴木淳史
    • Organizer
      第19回肝細胞研究会(シンポジウム)
    • Place of Presentation
      札幌
    • Year and Date
      2012-06-29
    • Related Report
      2012 Final Research Report
  • [Presentation] 肝芽細胞におけるRNA結合タンパク質とマイクロRNAによる細胞増殖の制御2012

    • Author(s)
      高島康郎、鈴木淳史
    • Organizer
      第19回肝細胞研究会
    • Place of Presentation
      札幌
    • Year and Date
      2012-06-29
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 肝細胞誘導におけるリプログラミング過程の観察と解析2012

    • Author(s)
      三浦静、関谷明香、大城戸絵理、鈴木淳史
    • Organizer
      第19回肝細胞研究会
    • Place of Presentation
      札幌
    • Year and Date
      2012-06-29
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 特定因子による皮膚細胞から肝細胞への直接転換2012

    • Author(s)
      鈴木淳史
    • Organizer
      第11回日本再生医療学会総会プレナリーセッション「幹細胞reprogrammingの現状と展望」
    • Place of Presentation
      横浜
    • Year and Date
      2012-06-13
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Induction of functional hepatocytes from mouse fibroblasts2012

    • Author(s)
      Atsushi Suzuki
    • Organizer
      47th annual meeting of the European Association for the Study of the Liver (The International Liver Congress by EASL)
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Directed cell fate reprogramming of fibroblasts to hepatocytes by defined factors2012

    • Author(s)
      鈴木 淳史
    • Organizer
      第45回日本発生生物学会・第64回日本細胞生物学会合同大会シンポジウム「Intrinsic and extrinsic control of stem cell systems」
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 肝臓の再生と疾患に関わる肝細胞の運命転換2012

    • Author(s)
      鈴木 淳史
    • Organizer
      第19回肝細胞研究会(シンポジウム)
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Directed cell fate reprogramming of mouse fibroblasts to hepatocyte-like cells2012

    • Author(s)
      鈴木 淳史
    • Organizer
      第33回日本炎症・再生医学会(International Symposium)
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Directed cell fate reprogramming of mouse fibroblasts to hepatocyte-like cells2012

    • Author(s)
      Atsushi Suzuki
    • Organizer
      ISSCR-Roddenberry International Symposium on Cellular Reprogramming
    • Place of Presentation
      San Francisco, CA
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Nanog-RFP1マウスの作製と解析2012

    • Author(s)
      寺田 茉衣子、関谷 明香、高島 康郎、鈴木 淳史
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] Fbxw7はマウスの肝臓において脂質代謝及び細胞分化決定を制御する2012

    • Author(s)
      磯下 理恵子、小野山 一郎、鈴木 淳史、松本 有樹修、冨田 謙吾、片桐 秀樹、尾池 雄一、中山 啓子、中山 敬一
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] Lin28b は肝芽細胞の増殖を制御する2011

    • Author(s)
      高島康郎、鈴木淳史
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-13
    • Related Report
      2012 Final Research Report
  • [Presentation] Lin28bは肝芽細胞の増殖を制御する2011

    • Author(s)
      高島康郎、鈴木淳史
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Induction of functional hepatocytes from fibroblasts by defined factors2011

    • Author(s)
      Atsushi Suzuki
    • Organizer
      2011 International Forum for Stem Cell Translational Research
    • Place of Presentation
      Shanghai, China(招待講演)
    • Year and Date
      2011-10-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肝臓の再生機構と発癌2011

    • Author(s)
      鈴木淳史
    • Organizer
      第70回日本癌学会学術総会・腫瘍別シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
    • Related Report
      2012 Final Research Report
  • [Presentation] 肝臓の再生機構と発癌2011

    • Author(s)
      鈴木淳史
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋(招待講演)
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肝幹細胞のプロスペクティブな解析 生体外の解析から生体内の解析へ2011

    • Author(s)
      鈴木淳史
    • Organizer
      日本遺伝学会第83回大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-22
    • Related Report
      2012 Final Research Report
  • [Presentation] 肝幹細胞のプロスペクティブな解析:生体外の解析から生体内の解析へ2011

    • Author(s)
      鈴木淳史
    • Organizer
      日本遺伝学会第83回大会
    • Place of Presentation
      京都(招待講演)
    • Year and Date
      2011-09-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] Induction of functional hepatocytes from fibroblasts by defined factors2011

    • Author(s)
      Atsushi Suzuki
    • Organizer
      The 7th FAOPS Congress
    • Place of Presentation
      Taipei, Taiwan(招待講演)
    • Year and Date
      2011-09-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Prospective isolation and clonal analysis of murine hepatic stem cells2010

    • Author(s)
      Atsushi Suzuki
    • Organizer
      BIT' s 3rd Annual World Congress Regenerative Medicine & Stem Cells
    • Place of Presentation
      Shanghai, China
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肝オーバル細胞の分離と系譜解析2010

    • Author(s)
      鈴木淳史
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-24
    • Related Report
      2012 Final Research Report
  • [Presentation] 肝オーバル細胞の分離と系譜解析2010

    • Author(s)
      鈴木淳史
    • Organizer
      第20回日本サイトメトリー学会
    • Place of Presentation
      東京
    • Year and Date
      2010-06-26
    • Related Report
      2012 Final Research Report
  • [Presentation] Prospective isolation and clonal analysis of hepatic stem cells in adult mouse liver2010

    • Author(s)
      Suzuki A
    • Organizer
      The 3rd Pan Pacific Symposium on Stem Cells Research
    • Place of Presentation
      Taichung, Taiwan
    • Year and Date
      2010-04-17
    • Related Report
      2012 Final Research Report
  • [Book] 「肝内胆管癌がNotchシグナルを介した肝細胞の分化転換から生じることを発見」、分子消化器病Vol.10,No.12013

    • Author(s)
      鈴木淳史
    • Related Report
      2012 Final Research Report
  • [Book] 「肝細胞分化を誘導するマスター因子の同定」、生化学、Vol.84,No.82012

    • Author(s)
      鈴木淳史
    • Related Report
      2012 Final Research Report
  • [Book] 「特定因子による細胞運命の直接転換」、実験医学増刊「幹細胞のメディカルサイエンス」、Vol.30,No.102012

    • Author(s)
      鈴木淳史
    • Related Report
      2012 Final Research Report
  • [Book] 「肝再生の仕組みに関する新知見-増殖を求め続ける肝細胞と負の制御」、医学のあゆみ、Vol.240,No.92012

    • Author(s)
      鈴木淳史
    • Related Report
      2012 Final Research Report
  • [Book] 「特定因子による皮膚細胞から肝細胞への直接変換」、分子消化器病、Vol.8,No.42011

    • Author(s)
      鈴木淳史
    • Related Report
      2012 Final Research Report
  • [Book] 「がん幹細胞とエピジェネティクス-環境の変化がいざなう細胞運命のリプログラミング」、実験医学増刊「がん幹細胞-ステムネス,ニッチ,標的治療への理解」、Vol.29,No.202011

    • Author(s)
      鈴木淳史
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.bioreg.kyushu-u.ac.jp/labo/orgreg/index.html

    • Related Report
      2012 Final Research Report
  • [Remarks] 研究室ホームページ

    • URL

      http://www.bioreg.kyushu-u.ac.jp/labo/orgreg/index.html

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.bioreg.kyushu-u.ac.jp/labo/orgreg/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.bioreg.kyushu-u.ac.jp/labo/orgreg/index.html

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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