| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2010: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Research Abstract |
Chromatin insulator is a boundary element that controls individualgene activity and gene cluster regions. We found that the insulator-binding protein CTCFforms chromatin loops and defines interactions between enhancer, promoter and insulator.Using chromosome conformation capture assay, we analyzed the higher-order epigenomicstructure in the human tumor necrosis factor/lymphotoxin (TNF/LT), and INK4/ARF gene loci.The chromatin loop formation and its dynamics were required for expression of these geneclusters.
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