Multifunction of chromatin insulator and epigenetic regulation
| Project/Area Number |
22390055
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2010: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | 遺伝子 / 転写 / インスレーター / エンハンサー / CTCF / プロモーター / クロマチン |
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| Research Abstract |
Chromatin insulator is a boundary element that controls individualgene activity and gene cluster regions. We found that the insulator-binding protein CTCFforms chromatin loops and defines interactions between enhancer, promoter and insulator.Using chromosome conformation capture assay, we analyzed the higher-order epigenomicstructure in the human tumor necrosis factor/lymphotoxin (TNF/LT), and INK4/ARF gene loci.The chromatin loop formation and its dynamics were required for expression of these geneclusters.
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Report
(4 results)
Research Products
(95 results)
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[Journal Article] Rb/E2F1 regulate innate immunereceptor Toll-like receptor 3 inepithelial cells2012
Author(s)
M. Taura, M.A. Suico, K. Koyama, K.Komatsu, R. Miyakita, C. Matsumoto, E.Kudo, R. Kariya, H. Goto, S. Kitajima, C.Takahashi, T. Shuto, M. Nakao, S. Okada,and H. Kai
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Journal Title
Mol. Cell. Biol
Volume: 32
Pages: 1581-1590
Related Report
Peer Reviewed
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