Mechanisms underlying oncogenesis by deregulation of glycolysis andp53-mediated tumor suppression.
| Project/Area Number |
22390062
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Nippon Medical School |
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Principal Investigator |
TANAKA Nobuyuki 日本医科大学, 大学院・医学研究科, 教授 (80222115)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2010: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | 分子腫瘍学 / p53 / グルコース代謝 / p21 / 発癌 / 癌抑制 / 炎症 / 炎症性サイトカイン / stat3 / NF-κB / Stat3 |
|---|
| Research Abstract |
We found that tumor suppressor p53 hampers aerobic glycolysis, and that enhanced energy provision by loss of p53 is important for oncogenesis in vitro. To identify the role of enhanced glycolysis in cancer development in vivo, we analyzed these effects in colitis-induced colon cancer. In colitis tissues, glycolysis was enhanced by IL-6, and p53-induced cell growth suppression was attenuated, suggesting thatthese effects are important for tumorigenesis.
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] The role of the BH3-only protein Noxa in bone homeostasis.2011
Author(s)
Idrus, E., Nakashima, T., Wang, L., Hayashi, M., Okamoto, K., Kodama, T.,Tanaka, N., Taniguchi, T., and Takayanagi, H.
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Journal Title
Biochem Biophys Res Commun
Volume: 410
Pages: 620-625
Related Report
Peer Reviewed
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[Journal Article] Interleukin 6 enhances glycolysis through expression of the glycolytic enzymes hexokinase 2 and6-phosphofructo-2-kinase/fructose-2,6-b isphosphatase-3.2010
Author(s)
Ando, M., Uehara, I., Kogure, K., Asano, Y., Nakajima, W., Abe, Y.,Kawauchi, K., and Tanaka, N.
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Journal Title
J Nippon Med Sch
Volume: 77
Pages: 97-105
Related Report
Peer Reviewed
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