| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2010: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Research Abstract |
We found that tumor suppressor p53 hampers aerobic glycolysis, and that enhanced energy provision by loss of p53 is important for oncogenesis in vitro. To identify the role of enhanced glycolysis in cancer development in vivo, we analyzed these effects in colitis-induced colon cancer. In colitis tissues, glycolysis was enhanced by IL-6, and p53-induced cell growth suppression was attenuated, suggesting thatthese effects are important for tumorigenesis.
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