Pathogenetical and etiological study on biliary diseases with respect to embryological close relation and cellular similarities to pancreas
| Project/Area Number |
22390067
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
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| Keywords | 付属腺 / 胆道腫瘍 / 膵腫瘍 / 膵外分泌腺 / 胆道 / Hes1 / Pdx1 |
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| Research Abstract |
Biliary tract and pancreas derive from endoderm foregut almost same time, and both show similar tissue and cellular structures and phenotypes. With respect to these similarities, the etiology and pathogenesis of biliary tract diseases were examined. The data obtained in this study were summarized as follows. I)Some of inflammatory diseases of the biliary tract and pancreas such as IgG4-related scloerosing disease and alcoholic pancreatitis and biliary disease were frequently overlapped and showed similar pathological features. II)Pancreatic duct adenocarcinoma and biliary tract carcinoma including their pre-neoplastic lesions showed similar pathological and phenotypic features. III) Intraductal papillary tumor of the pancreas and biliary tract also showed similar features and phenotypes. In conclusion, the data obtained in this study based on the similarities between pancreas and biliary tract were applicable in the therapeutical approaches of the biliary tract diseases.
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Report
(4 results)
Research Products
(108 results)
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[Journal Article] Intrahepatic Chorangiocaocinoma with predominant "Ductal Plate Malformation"pattern: A new subtype2012
Author(s)
Nakanuma Y, Sato Y, Ikeda H, Harada K, Kobayashi M, Sano K, Uehara T, Yamamoto M, Ariizumi S, Nyun Park Y, Choi JH, Yu E
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Journal Title
Am J Surg Pathol
Volume: 36(11)
Pages: 1629-1635
Related Report
Peer Reviewed
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[Journal Article] Intrahepatic Cholangiocarcinoma With Predominant "Ductal Plate Malformation" Pattern: A New Subtype.2012
Author(s)
Nakanuma Y, Sato y, Ikeda H, Harada K, Kobayashi M, Sano K, Uehara T, Yamamoto M, ariizumi S, Nyun Park Y, Choi JH, Yu E.
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Journal Title
Am J Surg Pathol
Volume: 36(11)
Pages: 1629-1635
Related Report
Peer Reviewed
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