Identification of cardiomyogenic factor in terms of cell-based therapy/regenerative medicine
Project/Area Number |
22390072
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Human pathology
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Research Institution | National Research Institute for Child Health and Development |
Principal Investigator |
UMEZAWA Akihiro 独立行政法人国立成育医療研究センター, 再生医療センター, センター長 (70213486)
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Co-Investigator(Kenkyū-buntansha) |
KURODA Masahiko 東京医科大学, 病理学教室, 教授 (80251304)
TOYODA Masashi 地方独立行政法人東京都健康長寿医療センター, 研究所老年病研究チーム, 研究副部長 (50392486)
三好 俊一郎 慶應義塾大学, 医学部・循環器内科, 講師 (10296577)
|
Project Period (FY) |
2010-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
Keywords | 細胞・組織 / タンパク質 / 心筋再生 / 液性因子 / 再生医療 / 循環器 / ヒト幹細胞 / 人体バイオリソース / 心筋細胞 / 血管新生 / 心筋分化誘導因子 / 分化誘導 |
Outline of Final Research Achievements |
We examined mesenchymal cells with an extended life span to investigate cardiomyogenic factors comprehensively. Among the mesenchymal cells, we focused on CD29-high CD34-low c-kit-positive CD140a-positive cells, and established a method to select cells capable of differentiating into cardiomyocytes in a high frequency. We implanted mesenchymal cells derived from a series of tissues including placenta into injured hearts. We herewith report to generate an experimental design to obtain proof of concept in a pre-clinical setting for cell-based therapy using tissue-derived mesenchymal cells to injured hearts.
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Report
(6 results)
Research Products
(4 results)
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[Journal Article] Pleiotropic functions of magnetic nanoparticles for ex vivo gene transfer.2014
Author(s)
Kami D, Kitani T, Kishida T, Mazda O, Toyoda M, Tomitaka A, Ota S, Ishii R, Takemura Y, Watanabe M, Umezawa A, Gojo S.
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Journal Title
Nanomedicine
Volume: 10
Issue: 6
Pages: 1165-1174
DOI
Related Report
Peer Reviewed / Open Access
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