Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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Outline of Final Research Achievements |
We examined mesenchymal cells with an extended life span to investigate cardiomyogenic factors comprehensively. Among the mesenchymal cells, we focused on CD29-high CD34-low c-kit-positive CD140a-positive cells, and established a method to select cells capable of differentiating into cardiomyocytes in a high frequency. We implanted mesenchymal cells derived from a series of tissues including placenta into injured hearts. We herewith report to generate an experimental design to obtain proof of concept in a pre-clinical setting for cell-based therapy using tissue-derived mesenchymal cells to injured hearts.
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