Development of a novel tumor immunotherapy that targets the soluble poliovirus receptor
Project/Area Number |
22390073
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Experimental pathology
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Research Institution | University of Tsukuba |
Principal Investigator |
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2012: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2011: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2010: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
|
Keywords | 免疫学 / 癌 / 生体分子 / 病理学 / がん / 分子標的療法 / 免疫逃避 / 免疫監視 / ポリオウイルスレセプター |
Research Abstract |
An activated immune receptor, DNAM-1, on T cells and NK cells binds to membrane-type poliovirus receptor (PVR) expressed on tumor cells, resulting in the immune surveillance against carcinogenesis. On the other hand, we found that the soluble PVR produced from tumor cells was involved in the escape from immune surveillance by DNAM-1. These results suggest that the soluble PVR can potentially be a target for novel cancer therapy that inhibit an immune escape, enhancing tumor immune surveillance by DNAM-1.
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Report
(4 results)
Research Products
(83 results)
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[Journal Article] Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor.2012
Author(s)
Nakahashi-Oda, C., Tahara-Hanaoka, S., Shoji, M., Okoshi, Y., Nakano-Yokomizo, T., Ohkohchi, N., Yasui, T., Kikutani, H., Honda, S., Shibuya, K., Nagata, S. and Shibuya, A.
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Journal Title
J Exp. Med.
Volume: 209
Issue: 8
Pages: 1493-1503
DOI
Related Report
Peer Reviewed
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[Journal Article] Overexpression of RORγt under control of the CD2 promoter induces polyclonal plasmacytosis and autoantibody production in transgenic mice2012
Author(s)
Yoh K, Morito N, Ojima M, Shibuya K, Yamashita Y, Morishima Y, Ishii Y, Kusakabe M, Nishikii H, Fujita A, Matsunaga E, Okamura M, Hamada M, Suto A, Nakajima H, Shibuya A, Yamagata K, Takahashi S
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Journal Title
Eur J Immunol
Volume: 42
Issue: 8
Pages: 1999-2009
DOI
Related Report
Peer Reviewed
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[Journal Article] An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions.2010
Author(s)
Hitomi K, Tahara-Hanaoka S, Someya S, Fujiki A, Tada H, Sugiyama T, Shibayama S, Shibuya K, Shibuya A
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Journal Title
Nature Immunology
Volume: 11
Issue: 7
Pages: 601-607
DOI
NAID
Related Report
Peer Reviewed
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[Presentation] A critical role of DNAM-1 in the development of acute graft-versus-host disease2010
Author(s)
Nabekura T, Shibuya K, Takenaka E, Kai H, Shibata K, Yamashita Y, Harada K, Tahara-Hanaoka S, Honda S, Shibuya A
Organizer
第14回国際免疫学会議
Place of Presentation
神戸国際会議場, 神戸
Year and Date
2010-08-26
Related Report
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[Presentation] MAIR- II(CD300d)plays a crucial role in inflammatory responses in a murine sepsis model2010
Author(s)
Totsuka N, Tahara-Hanaoka S, Nakahashi-Oda C, Kurita N, Nakano T, Yasui T, Kikutani H, Honda S, Shibuya K, Shibuya A
Organizer
第14回国際免疫学会議
Place of Presentation
神戸国際会議場, 神戸
Year and Date
2010-08-24
Related Report
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[Presentation] An immunoreceptor ando adaptor complex, MAIR- II/DAP12, negatively regulates B cell proliferation2010
Author(s)
Nakano T, Tahara-Hanaoka S, Kadozaki M, Nakahashi-Oda C, Totsuka N, Yasui T, Kikutani H, Shibuya K, Lanier L L, Shibuya A
Organizer
第14回国際免疫学会議
Place of Presentation
神戸国際会議場, 神戸
Year and Date
2010-08-23
Related Report
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[Presentation] A novel immunoglobulin-like receptor, Allergin-1, inhibits IgE-mediated allergic responses2010
Author(s)
Tahara-Hanaoka S, Hitomi K, Someya S, Fujiki A, Tada H, Sugiyama T, Shibayama S, Shibuya K, Shibuya A
Organizer
CSHL Meeting-Gene Expression & Signaling in the Immune System
Place of Presentation
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
Related Report
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